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Life cycle of Plasmodium

December 16, 2019 - 11:37 -- Miles Markus

Attention is drawn to a paper (by G. Franken, J. Richter, and A. Labisch) which points out, quite rightly, that it would be appropriate for more research on aspects of the life cycle of Plasmodium species that infect humans to be carried out, using modern techniques. The current "liver and blood" concept of the life cycle should not be regarded as the final "word" on the subject.

Link to the publication:


Submitted by Miles Markus on

Franken et al.’s paper is not about hypnozoites, but one on hypnozoites by Voorberg-van der Wel et al. that was published on 3 January 2020 (article details provided below) serves as a good example of how modern techniques can facilitate study of the life cycle of Plasmodium. The latter authors were able to actually follow the development of individual activated hypnozoites into schizonts. Being the first time that such support for the hypnozoite hypothesis of malarial relapse has been demonstrated, it is a significant advance in knowledge. The reference is:


Voorberg-van der Wel, A. et al. 2020. A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation. Communications Biology 3: 7.