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Malaria: the dramatic failure of mass drug administration

January 21, 2022 - 15:21 -- Pierre Lutgen

Against the malaria pandemia mass drug administration (MDA) of chloroquine, methylene blue, atabrine, pyrimethamine, mefloquine… was a component of many programs during the eradication era. It is far from a success story. The failure of chloroquine MDA is well known. Twenty years ago all these drugs were replaced by ACTs (artemisinin combined therapy).

      R D Powell, and C W D Tigertt. Drug Resistance of Parasites Causing Human Malaria. Annual Review of Medicine. Vol. 19: 81-102 (Volume publication date February 1968) DOI: 10.1146/annurev.me.19.020168.000501

What is MESA Track?

January 18, 2022 - 17:13 -- MESA Alliance

"What is MESA Track?" describes the MESA Track online platform, an open and living database of malaria research. This user-friendly and open-access tool informs the malaria community about which questions are being addressed, which innovative strategies are being tested, and aids collaboration and information-sharing.

The Wellcome Trust Bloomsbury Centre for Global Health: Research Global health research in Africa doctoral training programme – 2022-2027

January 11, 2022 - 06:41 -- Malaria World

This Wellcome Trust funded Programme is focusing on funding up to 5 PhD Fellowships per year, for 5 years and runs from 2022 to 2027 and will fund 25 Fellowships in total. It is open to early career healthcare professionals that have a focus on improving health and wellbeing in Africa. Applications from nurses, midwives, and allied health professionals (NMAHPs) are actively encouraged.

New link between sickle cell and severe malaria found

January 4, 2022 - 09:40 -- Malaria World

31.12.2021 - SciDev.Net

Malaria parasites may have adapted so that they can cause severe malaria in people with sickle cell disease, a study suggests.

Sickle cell, a group of conditions which can cause red blood cells to become sickle shaped, is become common in Africa because the genes responsible for the disease can help prevent malaria during early childhood, according to the World Health Organization (WHO).

Request for proposal: Global Grand Challenges - Building Malaria Modeling Capacity in Sub-Saharan Africa

December 23, 2021 - 09:46 -- Malaria World

Organisation: The Bill & Melinda Gates Foundation
Initiative: Grand Challenges Global Call-to-Action
Deadline for proposals: Jan 13, 2022, 11:30 am PST

Concealed Erythrocytic Parasites and Elimination of Plasmodium vivax

December 22, 2021 - 22:53 -- Miles Markus

In the malaria research field, prior events are sometimes overlooked (or ignored). Being formerly of a mild disposition (not always entirely so now, if provoked by displays of poor ethics), thirty years elapsed before I drew attention to one of these events. An analogy is that when you tread on the tail of a dinosaur, there can be a long delay before it turns its head.

Podcast: Wolbachia can control Anopheles malaria mosquito via ‘cytoplasmic incompatibility’

December 22, 2021 - 15:38 -- Johns Hopkins

Podcast #8 | 24 December 2021: Research on the Wolbachia bacteria is applied to the malaria-transmitting Anopheles mosquito, with exciting implications for vector control.

Artemisia afra, pancreas, diabetes

December 16, 2021 - 17:00 -- Pierre Lutgen

A few years ago, whilst running the clinical trials against malaria and bilharzia with Artemisia plants in Maniema, RDCongo, Dr. Jerome Munyangi noticed that these plants had cured or alleviated the diabetes of several patients.

     Munyangi J, Idumbo M, Mupenda B, Lutgen P. Five case reports on treatment of diabetes by Artemisia annua and Artemisia afra herbal tea. Pharm Pharmacol. Int J. 2020; 8(2):79‒85. DOI: 10.15406/ppij.2020.08.00283

This finding was recently confirmed by a case study in Burundi (see annex 1).

All you need to know about... the MESA Deep Dives

December 14, 2021 - 12:06 -- MESA Alliance

What are the Deep Dives?

The Deep Dives show -as far as possible- the state of the art of the main malaria research topics. Taking MESA Track as the information source, the Deep Dives gather all the projects around a specific research question and classify them according to research areas, timelines and geographic locations. The Deep Dives also include information on funding sources, principal institutions and principal investigators.

WHO: Malaria diagnosis - Addressing the issue of HRP2 gene deletions

December 13, 2021 - 17:49 -- Malaria World

Access to an accurate and timely diagnosis is critical to preventing a malaria infection from progressing to severe illness and death. WHO recommends prompt malaria diagnosis either through microscopy or rapid diagnostic tests (RDTs) for all patients with suspected malaria. The hundreds of millions of RDTs sold each year are designed to detect a specific protein in a person’s blood. Parasites that have mutated to no longer express that protein can evade detection by RDTs.

WHO Report - State of inequality: HIV, tuberculosis and malaria

December 9, 2021 - 20:29 -- Malaria World


This report is the first systematic global analysis of the state of inequality in HIV, TB and malaria. Drawing from two decades of global data about for a range of disease indicators and multiple dimensions of inequality, it aims to facilitate a broad understanding of inequalities in HIV, TB and malaria.

The state of inequality analysis assesses the latest situation of inequality (2011–2020), and shows how this compares to the previous decade (2001–2010). For each disease, analyses are contextualized within the current state of knowledge from the broader literature, including information about key and underserved populations. The report examines the implications of the findings, featuring examples of approaches to address unfair and remediable inequalities and opportunities for strengthening inequality monitoring. Additional resources accompany the report, including interactive visuals and data.

Podcast: Rising malaria cases and deaths in 2020 attributed to pandemic disruptions

December 8, 2021 - 17:12 -- Johns Hopkins

Podcast #7 | 10 December 2021: Malaria cases rose in 2020, as did death from the disease--by 12%. What caused this? Learn more about these stark findings just published in the 2021 World Malaria Report.

Can P. vivax sporozoites having the same genotype be both tachysporozoites and bradysporozoites?

December 2, 2021 - 01:13 -- Miles Markus

Lysenko et al.’s hypothetical P. vivax tachysporozoites [1] multiply in the liver soon after inoculation into the host, whereas their hypothetical bradysporozoites form hypnozoites [1], which are the origin of relapses. This "tachy" and "brady" terminology is an extension of usage unrelated to malaria [2].

Homologous P. vivax malarial recurrences are not necessarily relapses

November 26, 2021 - 10:29 -- Miles Markus

It was pointed out a decade ago that non-reinfection recurrences of Plasmodium vivax malaria caused by parasites that are closely related to those from an earlier time point are highly suggestive of a merozoite origin [1,2].

This would make them recrudescences (in an unknown proportion of cases), not relapses. In other words, hypnozoites [3] have nothing to do with such a recurrence.

Some recurrences that take place after 28 days post infection are also recrudescences (not relapses), as has recently been explained [2].

 

 

REFERENCES

Podcast: DNA sequencing unveils workings of malaria recurrence in low parasitemia infections

November 24, 2021 - 15:52 -- Johns Hopkins

Podcast #6 | 26 November 2021: New scientific insights into malaria recurrence in low parasitemia infections is due to relapse rather than infection, determined by DNA sequencing.

MESA Webinar 6 - Malaria in the Shadows: Putting the Focus on the Challenges of P. vivax

November 24, 2021 - 14:00 -- MESA Alliance

 

MESA is thrilled to welcome you to the sixth session of the MESA Webinars: Science for Malaria Impact, a platform that brings together the malaria community of innovators and showcases the work of malaria-endemic researchers!

ASTMH 2021 Annual Meeting (virtual): Day 2

November 23, 2021 - 20:53 -- MESA Alliance


MESA Correspondents bring you cutting-edge coverage from the virtual ASTMH 2021 Annual Meeting

Day 2: Thursday, 18th November 2021


Symposium #12: Entomological Data to Guide Strategic Deployment of New Types of Insecticide Treated Nets for Control of Pyrethroid Resistant Malaria Vectors

ASTMH 2021 Annual Meeting (virtual): Day 1

November 19, 2021 - 11:34 -- MESA Alliance


MESA Correspondents bring you cutting-edge coverage from the virtual ASTMH 2021 Annual Meeting

Day 1: Wednesday, 17th November 2021

The 70th Annual ASTMH virtual meeting started with the Young Investigator Award Sessions. These awards are given for work presented by young investigators to recognise their work and to encourage young scientists to pursue careers in tropical disease research.

Artemisia afra irreversibly cures tuberculosis

November 16, 2021 - 21:19 -- Pierre Lutgen

Early this year we published the results of 15 case studies. In 2020 15 patients infected by tuberculosis had been cured after 3 weeks of administration of Artemisia afra infusions, alone or in combination with the WHO prescribed drugs.

      Daddy B, Lutgen P, Gisenya P. Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions. Pharm Pharmacol Int J. 2021;9(2):58‒62.

Meanwhile in several countries of the Great Lakes, the tuberculosis of some 30 additional patients has been cured, mostly by Artemisia afra alone.

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