Against the malaria pandemia mass drug administration (MDA) of chloroquine, methylene blue, atabrine, pyrimethamine, mefloquine… was a component of many programs during the eradication era. It is far from a success story. The failure of chloroquine MDA is well known. Twenty years ago all these drugs were replaced by ACTs (artemisinin combined therapy).
R D Powell, and C W D Tigertt. Drug Resistance of Parasites Causing Human Malaria. Annual Review of Medicine. Vol. 19: 81-102 (Volume publication date February 1968) DOI: 10.1146/annurev.me.19.020168.000501