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Pierre Lutgen's blog

Malaria: the dramatic failure of mass drug administration

January 21, 2022 - 15:21 -- Pierre Lutgen

Against the malaria pandemia mass drug administration (MDA) of chloroquine, methylene blue, atabrine, pyrimethamine, mefloquine… was a component of many programs during the eradication era. It is far from a success story. The failure of chloroquine MDA is well known. Twenty years ago all these drugs were replaced by ACTs (artemisinin combined therapy).

      R D Powell, and C W D Tigertt. Drug Resistance of Parasites Causing Human Malaria. Annual Review of Medicine. Vol. 19: 81-102 (Volume publication date February 1968) DOI: 10.1146/annurev.me.19.020168.000501

Artemisia afra, pancreas, diabetes

December 16, 2021 - 17:00 -- Pierre Lutgen

A few years ago, whilst running the clinical trials against malaria and bilharzia with Artemisia plants in Maniema, RDCongo, Dr. Jerome Munyangi noticed that these plants had cured or alleviated the diabetes of several patients.

     Munyangi J, Idumbo M, Mupenda B, Lutgen P. Five case reports on treatment of diabetes by Artemisia annua and Artemisia afra herbal tea. Pharm Pharmacol. Int J. 2020; 8(2):79‒85. DOI: 10.15406/ppij.2020.08.00283

This finding was recently confirmed by a case study in Burundi (see annex 1).

Artemisia afra irreversibly cures tuberculosis

November 16, 2021 - 21:19 -- Pierre Lutgen

Early this year we published the results of 15 case studies. In 2020 15 patients infected by tuberculosis had been cured after 3 weeks of administration of Artemisia afra infusions, alone or in combination with the WHO prescribed drugs.

      Daddy B, Lutgen P, Gisenya P. Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions. Pharm Pharmacol Int J. 2021;9(2):58‒62.

Meanwhile in several countries of the Great Lakes, the tuberculosis of some 30 additional patients has been cured, mostly by Artemisia afra alone.

Do vaccines increase Malaria and Covid ?

October 30, 2021 - 16:23 -- Pierre Lutgen

The efficacy of vaccines is a complex issue and sometimes long range effects may be disastrous.

The situation is dramatic for the RTS,S vaccine which protects only against sporozoites but does not induce clinical immunity against blood-stage parasites. The vaccine showed evidence of 35,9% efficacy in the first year after vaccination, but efficacy fell to 2.5% in the fourth year. The cohort with a high exposure index even showed a negative efficacy during the fifth year, i.e. an higher level of infection

Saponins, tuberculosis and malaria

October 4, 2021 - 16:58 -- Pierre Lutgen

A team of medical doctors in Nord Kivu discovered that Artemisia afra infusions were very efficient in the therapy of tuberculosis patients.

   Daddy B, Lutgen P, Gisenya P. Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions. Pharm Pharmacol Int J. 2021;9(2):58‒62. DOI: 10.15406/ppij.2021.09.00328

Some other plants are also known to have an antituberculosis effect. For example, Entada abyssinica, a Fabaceae, rich in saponins was found to be be very efficient in vitro against Mycobacterium tuberculosis.

Artemisia afra, alcohol and tuberculosis

September 6, 2021 - 19:19 -- Pierre Lutgen

African medical doctors have discovered that infusions of Artemisia afra administered during 20 days definitely and totally cured tuberculosis, even for patients where drugs administred in conformity with the WHO protocol had failed. We quote one of their papers hereafter, but they have run dozens of similar successfull treatments in several countries of the region of the Great Lakes in Africa.

Hemozoin and Malaria : a love-hate affair

July 5, 2021 - 17:31 -- Pierre Lutgen

Mutaz Akkawi, Pascal Gisenya, Jérôme Munyangi, Pierre Lutgen

…or the key of malaria transmission.

Already 25 years ago it was known that malaria pigment (hemozoin, Hz, biocrystallized heme) is not an inert material. Crude pigment, as present in infected erythrocytes and shed after schizont rupture, may be considered the 'natural diet' ingested by macrophages in infected blood. Hemozoin is a powerful source of radicals, necrosis factor-alpha, interleukins 1 and 6.

Arginine, Malaria, Helminths and Covid,

March 15, 2021 - 20:06 -- Pierre Lutgen

In my recent weblog « Africa, Covid and Schistosomiasis » I documented that eosinophilia is common in helminthic infections (www.malariaworld.org 14/01/2021) and that this might significatly contribute to a protection against viral infections. And that this could explain the low incidence of Covid in tropical African countries.

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