The presumed hypnozoite reservoir is perceived to be a threat to the goal of eradicating human malaria. However, the same now applies to putative non-hypnozoite tissue stages as well, notably quiescent merozoites. Persistence of extra-vascular tissue merozoites in vivax malaria has on genetic grounds been suspected since 2011. So far, they have been parasitologically demonstrated in rodent malarial infections. There is no particular reason why they should not also occur in primate malaria of various kinds.