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NOT Open Access | High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon

November 5, 2021 - 13:41 -- NOT Open Access
Fogang B, Biabi MF, Ayong L, et al.
Am J Trop Med Hyg. 2021 Nov 1:tpmd210316

Asymptomatic malarial parasitemia is highly prevalent in Plasmodium falciparum endemic areas and often associated with increased prevalence of mild to moderate anemia. The aim of this study was to assess the prevalence of anemia during asymptomatic malaria parasitemia and its interplay with persistent infection in highly exposed individuals. A household-based longitudinal survey was undertaken in a malaria hyperendemic area in Cameroon using multiplex nested polymerase chain reaction to detect plasmodial infections.

Molecular detection and maternal transmission of a bacterial symbiont Asaia species in field-caught Anopheles mosquitoes from Cameroon

October 20, 2021 - 19:58 -- Open Access
Maffo CGT, Sandeu MM, Fadel AN, Tchouakui M, Nguete DN, Menze B, Kusimo MO, Njiokou F, Hughes GL, Wondji CS
Parasit Vectors. 2021 Oct 17;14(1):539

Malaria control relies mainlyon insecticide-based tools. However, the effectiveness of these tools is threatened by widespread insecticide resistance in malaria vectors, highlighting the need for alternative control approaches. The endosymbiont Asaia has emerged as a promising candidate for paratransgenic control of malaria, but its biology and genetics still need to be further analyzed across Africa. Here, we investigated the prevalence of Asaia and its maternal transmission in the natural population of Anopheles mosquitoes in Cameroon.

An update on the mosquito fauna and mosquito-borne diseases distribution in Cameroon

October 13, 2021 - 12:32 -- Open Access
Bamou R, Mayi MPA, Djiappi-Tchamen B, Nana-Ndjangwo SM, Nchoutpouen E, Cornel AJ, Awono-Ambene P, Parola P, Tchuinkam T, Antonio-Nkondjio C
Parasit Vectors. 2021 Oct 11;14(1):527

The expansion of mosquito-borne diseases such as dengue, yellow fever, and chikungunya in the past 15 years has ignited the need for active surveillance of common and neglected mosquito-borne infectious diseases. The surveillance should be designed to detect diseases and to provide relevant field-based data for developing and implementing effective control measures to prevent outbreaks before significant public health consequences can occur.

NOT Open Access | Efficacy of dihydroartemisinin/piperaquine in patients with non-complicated Plasmodium falciparum malaria in Yaounde, Cameroon

September 1, 2021 - 16:24 -- NOT Open Access
Mairet-Khedim M, Nsango S, Berry A, et al.
J Antimicrob Chemother. 2021 Aug 28:dkab281

Dihydroartemisinin/piperaquine is increasingly used for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. The efficacy of this combination in Cameroon is poorly documented, while resistance to dihydroartemisinin/piperaquine readily spreads in Southeast Asia.

High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial

August 25, 2021 - 17:15 -- Open Access
Antonio-Nkondjio C, Doumbe-Belisse P, Wondji CS, et al.
Sci Rep. 2021 Aug 24;11(1):17101

The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable, the addition of anti-larval control measures could be efficient for malaria vector control. But field evidences for this approach remains scarce.

Antimalarial drug resistance in the Central and Adamawa regions of Cameroon: Prevalence of mutations in P. falciparum crt, Pfmdr1, Pfdhfr and Pfdhps genes

August 25, 2021 - 16:18 -- Open Access
Tuedom AGB, Sarah-Matio EM, Nsango SE, et al.
PLoS One. 2021 Aug 19;16(8):e0256343

The spread of Plasmodium falciparum resistant parasites remains one of the major challenges for malaria control and elimination in Sub Saharan Africa. Monitoring of molecular markers conferring resistance to different antimalarials is important to track the spread of resistant parasites and to optimize the therapeutic lifespan of current drugs. This study aimed to evaluate the prevalence of known mutations in the drug resistance genes Pfcrt, Pfmdr1, Pfdhfr and Pfdhps in two different epidemiological settings in Cameroon. Dried blood spots collected in 2018 and 2019 from asymptomatic individuals were used for DNA extraction and then the Plasmodium infection status was determined byPCR.

Insecticide-treated net ownership, utilization and knowledge of malaria in children residing in Batoke–Limbe, Mount Cameroon area: effect on malariometric and haematological indices

August 4, 2021 - 16:10 -- Open Access
Rene Ning Teh, Irene Ule Ngole Sumbele, Derick Ndelle Meduke, Gillian Asoba Nkeudem, Samuel Takang Ojong, Exodus Akwa Teh and Helen Kuokuo Kimbi
Malaria Journal 2021 20:333, 29 July 2021

Insecticide-treated nets (ITNs) are the most widely used interventions for malaria control in Africa. The aim of this study was to assess the ownership and utilization of ITNs and the knowledge of malaria and their effects on malariometric and haematological indices in children living in the Mount Cameroon area.

NOT Open Access | High genetic complexity but low relatedness in Plasmodium falciparum infections from Western Savannah Highlands and coastal equatorial Lowlands of Cameroon

July 28, 2021 - 14:12 -- NOT Open Access
Atuh NI, Anong DN, Jerome FC, Oriero E, Mohammed NI, D'Alessandro U, Amambua-Ngwa A
Pathog Glob Health. 2021 Jul 26:1-10

To determine the diversity and connectivity of infections in Northwestern and Southwestern Cameroon, 232 Plasmodium falciparum infections, collected in 2018 from the Ndop Health District (NHD) in the western savannah highlands in the Northwest and the Limbe Health District (LHD) in the coastal lowland forests in the Southwest of Cameroon were genotyped for nine neutral microsatellite markers.

NOT Open Access | In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA

July 28, 2021 - 13:55 -- NOT Open Access
Toukam LL, Tatsinkou Fossi B, Taiwe GS, Bila RB, Feugaing Sofeu DD, Ivo EP, Achidi EA
J Ethnopharmacol. 2021 Jul 22:114448

Milk production, processing and consumption are integral part of traditional practices in Fulani tribe of Cameroon. It has been observed that Fulani are resistant to malaria. Dairy products traditionally processed by Fulani are intensively used in the ritual treatment of malarial, inflammations and behavioural disorders. Many studies have demonstrated that fermented milk is a rich source of probiotic bacteria. However, the antimalarial activity of probiotics isolated from this natural source has not been experimentally tested.

Not Open Access | First evidence of local circulation of Plasmodium ovale curtisi and reliability of a malaria rapid diagnostic test among symptomatic outpatients in Douala, Cameroon

July 6, 2021 - 14:16 -- NOT Open Access
Kojom Foko LP, Kouemo Motse FD, Kamgain Mawabo L, Pande V, Singh V
Infect Genet Evol. 2021 Jul;91:104797

The performances of a commonly used Plasmodium falciparum-detecting rapid diagnostic test (RDT) were determined in symptomatic individuals living in Cameroon. Discrepancies between RDT and light microscopy (LM) results were further investigated, with a focus on non-falciparum malaria (NFM) which are still largely understudied in sub-Saharan Africa (sSA) countries. In the present study, a total of 355 individuals aged 1-65 years were enrolled in the study. Their signs/symptoms and sociodemographic characteristics were documented.


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