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Home-Based Intervention for the Prevention and Treatment of Malaria Among Children Younger Than 5 Years in the West Region of Cameroon: Protocol for a Randomized Controlled Trial

March 17, 2021 - 17:05 -- Open Access
Dongmo Kenfack E, Tendongfor N, Nsagha DS
JMIR Res Protoc. 2021 Mar 12;10(3):e19633

Although malaria is preventable and curable, 1 child dies of this disease every 2 minutes in Africa. Home-based management of malaria reduces the progression of severe malaria by more than 50%. Scalable, efficacious, and cost-effective strategies are needed to empower the capacities of home caregivers of children younger than 5 years of age in health education, diagnosis, and treatment of malaria at home.

NOT Open Access | Does Antibody Avidity to Plasmodium falciparum Merozoite Antigens increase with Age in Individuals living in Malaria-Endemic Areas

March 17, 2021 - 17:01 -- NOT Open Access
Yunga ST, Bobbili N, Lloyd YM, Antallan J, Matsunaga M, Quakyi I, Leke RFG, Taylor DW
Infect Immun. 2021 Mar 15:IAI.00522-20

High avidity antibodies (Abs) are acquired after a few Plasmodium falciparum infections in low transmission areas, but it remains unclear if Ab avidity to different merozoite antigens increases with age in individuals with persistent antigenemia and if so, when a fully mature Ab response occurs.

Intestinal helminths as predictors of some malaria clinical outcomes and IL-1beta levels in outpatients attending two public hospitals in Bamenda, North West Cameroon

March 4, 2021 - 11:17 -- Open Access
Ntonifor HN, Chewa JS, Oumar M, Mbouobda HD
PLoS Negl Trop Dis. 2021 Mar 2;15(3):e0009174

This study aimed at determining the impact of intestinal helminths on malaria parasitaemia, anaemia and pyrexia considering the levels of IL-1β among outpatients in Bamenda. A cohort of 358 consented participants aged three (3) years and above, both males and females on malaria consultation were recruited in the study. At enrolment, patients' axillary body temperatures were measured and recorded. Venous blood was collected for haemoglobin concentration and malaria parasitaemia determination. Blood plasma was used to measure human IL-1β levels using Human ELISA Kit.

Polyparasitism with Schistosoma haematobium, Plasmodium and soil-transmitted helminths in school-aged children in Muyuka-Cameroon following implementation of control measures: a cross sectional study

February 25, 2021 - 10:05 -- Open Access
Sumbele IUN, Otia OV, Bopda OSM, Ebai CB, Kimbi HK, Nkuo-Akenji T
Infect Dis Poverty. 2021 Feb 17;10(1):14

Despite the ubiquity of polyparasitism, its health impacts have been inadequately studied. The aim of this study was to determine the prevalence and determinants of polyparasitism with Schistosoma haematobium, Plasmodium and soil-transmitted helminths (STH) following sustained control measures, as well as evaluate the outcomes and clinical correlates of infection in school-aged children (SAC) living in the schistosomiasis endemic focus of Muyuka-Cameroon.

Diagnostic performance of a rapid whole blood-based RT-LAMP method for malaria diagnosis among apparently healthy blood donors and febrile neonates in Cameroon

February 2, 2021 - 16:38 -- Open Access
Zebaze Temgoua Kemleu SG, Ngando L, Nguekeng E, Fogang B, Mafo Kapen M, Fopa SI, Biabi MF, Essangui E, Assob Nguedia JC, Ayong L
PLoS One. 2021 Jan 28;16(1):e0246205

Light microscopy and rapid diagnostic tests are the two commonly used methods for malaria diagnosis that rely on the direct use of unprocessed blood samples. However, both methods do not have the level of sensitivity required for malaria diagnosis in cases of low density parasitaemia. We report here the diagnostic performance of a whole blood-based reverse transcription loop-mediated isothermal amplification method for Plasmodium falciparum malaria diagnosis in apparently healthy blood donors and febrile neonates in Cameroon.

Evaluation of malaria preventive measures among adult patients attending the Bamendjou and Foumbot district hospitals of the West Region of Cameroon

January 27, 2021 - 15:44 -- Open Access
Nfor Omarine Nlinwe, Yengong Clinton Singong and Tenkam Makamdoum Ruth Florentine
Malaria Journal 2021 20:60, 22 January 2021

Although a significant decrease in entomological and epidemiological indicators was reported in Cameroon since the introduction of insecticide-treated bed nets, malaria prevalence remains high also in some parts of the West Region of Cameroon. This study was designed to evaluate malaria preventive measures among patients attending the Bamendjou and Foumbot District hospitals of the West Region of Cameroon.

Malaria and intestinal parasite co-infection and its association with anaemia among people living with HIV in Buea, Southwest Cameroon: A community-based retrospective cohort study

January 27, 2021 - 10:45 -- Open Access
Mekachie Sandie S, Sumbele IUN, Tasah MM, Kimbi HK
PLoS One. 2021 Jan 22;16(1):e0245743

Both malaria and intestinal parasites are endemic in Cameroon, and their co-infection can be of great impact on anaemia among people living with HIV (PLWH). This community-based retrospective cohort study determined the prevalence and association of infections with anaemia in PLWH and HIV-negative individuals in Buea, Cameroon from March to August 2019.

Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

January 13, 2021 - 10:01 -- Open Access
Peter Thelma Ngwa Niba, Akindeh M. Nji, Wilfred F. Mbacham, et al.
Malaria Journal 2021 20:32, 9 January 2021

Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon from January 1998 to August 2020.

Preliminary validation of the use of IgG antibody response to Anopheles gSG6-p1 salivary peptide to assess human exposure to malaria vector bites in two endemic areas of Cameroon in Central Africa

January 6, 2021 - 13:01 -- Open Access
Cheteug G, Elanga-Ndille E, Donkeu C, Ekoko W, Oloume M, Essangui E, Nwane P, NSango SE, Etang J, Wanji S, Ayong L, Eboumbou Moukoko CE
PLoS One. 2020 Dec 31;15(12):e0242510

The specific immune response to the Anopheles salivary peptide could be a pertinent and complementary tool to assess the risk of malaria transmission and the effectiveness of vector control strategies. This study aimed to obtain first reliable data on the current state of the Anopheles gSG6-P1 biomarker for assess the level of exposure to Anopheles bites in high malaria endemic areas in Cameroon.

NOT Open Access | Investigation of Dengue-Malaria co-infection among febrile patients consulting at Ngaoundere Regional Hospital, Cameroon

December 16, 2020 - 12:51 -- NOT Open Access
Galani BRT, Mapouokam DW, Nemg Simo FB, Mohamadou H, Djamen Chuisseu PD, Njintang NY, Moundipa PF
J Med Virol. 2020 Dec 15

This study aimed at evaluating the seroprevalence of dengue among malarious patients consulting at the Ngaoundere regional hospital. During 2 months and a half, 174 participants were recruited and their blood samples were screened for Plasmodium spp and then for Dengue virus (DENV) infection using rapid diagnostic tests. Also, hematological parameters were measured using a hematology autoanalyzer. Among patients tested, 134 (77.01%) were malaria-positive, and 12/134 (8.95%) were co-infected. In this population, 8/12 (66.67%) were only anti-DENV IgM-positive, 3/12 (25%) were both NS1 and anti-DENV IgM positive, and 1/12 (8.33%) were anti-DENV IgG-positive.


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