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Baseline malaria prevalence and care-seeking behaviours in rural Madagascar prior to a trial to expand malaria community case management to all ages

November 18, 2021 - 11:48 -- Open Access
Dean Sayre, Laura C. Steinhardt, Aina Harimanana, et al.
Malaria Journal 2021 20:422, 26 October 2021

Integrated community case management of malaria, pneumonia, and diarrhoea can reduce mortality in children under five years (CU5) in resource-poor countries. There is growing interest in expanding malaria community case management (mCCM) to older individuals, but limited empirical evidence exists to guide this expansion. As part of a two-year cluster-randomized trial of mCCM expansion to all ages in southeastern Madagascar, a cross-sectional survey was conducted to assess baseline malaria prevalence and healthcare-seeking behaviours.

Prevalence of malaria in an area receiving seasonal malaria chemoprevention in Niger

November 18, 2021 - 11:30 -- Open Access
Matthew E. Coldiron, Bachir Assao, Ousmane Guindo, Nathan Sayinzoga-Makombe, Alena Koscalova, Esther Sterk, Michel Quere, Iza Ciglenecki, Ann Mumina, Salifou Atti, Céline Langendorf and Rebecca F. Grais
Malaria Journal 2021 20:419, 24 October 2021

Malaria transmission is highly seasonal in Niger. Despite the introduction of seasonal malaria chemoprevention (SMC) in the Magaria District, malaria incidence remains high, and the epidemiology of malaria in the community is not well-understood.

Population-specific adaptation in malaria-endemic regions of Asia

November 13, 2021 - 10:30 -- Open Access
Gusareva ES, Lorenzini PA, Ramli NAB, Ghosh AG, Kim HL
J Bioinform Comput Biol. 2021 Nov 10:2140006

Evolutionary mechanisms of adaptation to malaria are understudied in Asian endemic regions despite a high prevalence of malaria in the region. In our research, we performed a genome-wide screening for footprints of natural selection against malaria by comparing eight Asian population groups from malaria-endemic regions with two non-endemic population groups from Europe and Mongolia.

Baseline malaria prevalence at the targeted pre-elimination districts in Ethiopia

November 4, 2021 - 12:58 -- Open Access
Nega D, Abera A, Abate E, et al.
BMC Public Health. 2021 Nov 3;21(1):1996

Encouraged by the previous success in malaria control and prevention strategies, the Ethiopian ministry of health launched malaria elimination with a stepwise approach by primarily targeting the low-transmission Districts and their adjacent areas/zones in order to shrink the country’s malaria map progressively. Hence, this community survey was conducted to establish baseline malaria information at the preliminary phase of elimination at targeted settings.

Prevalence and associated factors of malaria in children under the age of five years in Wogera district, northwest Ethiopia: A cross-sectional study

October 16, 2021 - 13:00 -- Open Access
Tsegaye AT, Ayele A, Birhanu S
PLoS One. 2021 Oct 11;16(10):e0257944

Malaria is a major public health problem in sub-Saharan Africa, and children are especially vulnerable. In 2019, an estimated 409,000 people died of malaria, most (274,000) were young children and 94% of the cases and deaths were in Africa. Prior studies in Ethiopia focused on the adult population and high transmission areas. Hence, this study aimed to determine the prevalence and associated factors of malaria in children under five years in low transmission areas.

Malaria prevalence and associated risk factors in Dembiya district, North-western Ethiopia

September 28, 2021 - 09:45 -- Open Access
Mihretu Tarekegn, Habte Tekie, Sisay Dugassa and Yitbarek Wolde-Hawariat
Malaria Journal 2021 20:372, 17 September 2021

Ethiopia embarked on combating malaria with an aim to eliminate malaria from low transmission districts by 2030. A continuous monitoring of malaria prevalence in areas under elimination settings is important to evaluate the status of malaria transmission and the effectiveness of the currently existing malaria intervention strategies. The aim of this study was to assess the prevalence of malaria and associated risk factors in selected areas of Dembiya district.

The association between malaria prevalence and COVID-19 mortality

September 23, 2021 - 10:40 -- Open Access
Anyanwu MU
BMC Infect Dis. 2021 Sep 19;21(1):975

The number of persons infected with COVID-19 continues to increase with deaths reported daily across the globe. High income countries such as the US, the UK, Italy and Belgium have reported high COVID-19 related deaths but low-and-middle-income countries have recorded fewer deaths despite having poor healthcare system. This study aimed to investigate the association between malaria prevalence and COVID-19 mortality.

A predictive model, and predictors of under-five child malaria prevalence in Ghana: How do LASSO, Ridge and Elastic net regression approaches compare

September 1, 2021 - 17:26 -- Open Access
Aheto JMK, Duah HO, Agbadi P, Nakua EK
Prev Med Rep. 2021 Jun 27;23:101475

Malaria is among the leading causes of mortality and morbidity among children in Ghana. Therefore, identifying the predictors of malaria prevalence in children under-five is among the priorities of the global health agenda. In Ghana, the paradigm shifts from using traditional statistics to machine learning techniques to identifying predictors of malaria prevalence are scarce.

Elucidating relationships between P.falciparum prevalence and measures of genetic diversity with a combined genetic-epidemiological model of malaria

August 25, 2021 - 16:03 -- Open Access
Hendry JA, Kwiatkowski D, McVean G
PLoS Comput Biol. 2021 Aug 19;17(8):e1009287

There is an abundance of malaria genetic data being collected from the field, yet using these data to understand the drivers of regional epidemiology remains a challenge. A key issue is the lack of models that relate parasite genetic diversity to epidemiological parameters. Classical models in population genetics characterize changes in genetic diversity in relation to demographic parameters, but fail to account for the unique features of the malaria life cycle.

NOT Open Access | High genetic complexity but low relatedness in Plasmodium falciparum infections from Western Savannah Highlands and coastal equatorial Lowlands of Cameroon

July 28, 2021 - 14:12 -- NOT Open Access
Atuh NI, Anong DN, Jerome FC, Oriero E, Mohammed NI, D'Alessandro U, Amambua-Ngwa A
Pathog Glob Health. 2021 Jul 26:1-10

To determine the diversity and connectivity of infections in Northwestern and Southwestern Cameroon, 232 Plasmodium falciparum infections, collected in 2018 from the Ndop Health District (NHD) in the western savannah highlands in the Northwest and the Limbe Health District (LHD) in the coastal lowland forests in the Southwest of Cameroon were genotyped for nine neutral microsatellite markers.


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