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cerebral malaria

NOT Open Access | α-Tocopheryl succinate-suppressed development of cerebral malaria in mice

October 2, 2018 - 16:33 -- NOT Open Access
Aiko Kume, Shunji Kasai, Hana Furuya & Hiroshi Suzuki
Parasitology Research, October 2018, Volume 117, Issue 10, pp 3177–3182

α-Tocopheryl succinate (α-TOS), a derivative of vitamin E, is synthesized by esterification of α-tocopherol.

Proteomic profiling of the plasma of Gambian children with cerebral malaria

September 25, 2018 - 15:15 -- Open Access
Ehab M. Moussa, Honglei Huang, Climent Casals-Pascual, et al.
Malaria Journal 2018 17:337, 24 September 2018

The results indicate that increased tissue damage and hypercoagulability may play an important role in fatal CM.


Not Open Access | Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

July 14, 2018 - 15:27 -- NOT Open Access
Patrick Strangward, Michael J. Haley, Kevin N. Couper, et al.
PNAS June 28, 2018. 201801737

Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

May 22, 2018 - 14:14 -- Open Access
Douglas G. Postels, Xiaoting Wu, Gretchen L. Birbeck, et al.
Malaria Journal 2018 17:208, 22 May 2018

Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.

Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria

May 15, 2018 - 14:35 -- Open Access
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E. R. Grau and Valery Combes
Malaria Journal 2018 17:192, 11 May 2018

These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.

NOT Open Access | Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

April 19, 2018 - 15:34 -- NOT Open Access
Kristina S. Burrack, Matthew A. Huggins, Sara E. Hamilton, et al.
Immunity Volume 48, Issue 4, 17 April 2018, Pages 760-772.e4

Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells.

Cerebrospinal fluid Plasmodium falciparum histidine-rich protein-2 in pediatric cerebral malaria

March 27, 2018 - 15:47 -- Open Access
Kiran T. Thakur, Jimmy Vareta, Karl B. Seydel, et al.
Malaria Journal 2018 17:125, 23 March 2018

Elevation of CSF, but not plasma PfHRP-2, is associated with death in this paediatric CM cohort. PfHRP-2 egress into the CSF may represent alteration of blood brain barrier permeability related to the sequestration of parasitized erythrocytes in the cerebral microvasculature.

NOT Open Access | Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis

February 1, 2018 - 16:15 -- NOT Open Access
J. Palomo, V. F. J. Quesniaux, D. Togbe, F. Reverchon and B. Ryffel
Parasite Immunology, Volume 40, Issue 2, February 2018

Cerebral malaria (CM) is one complication of Plasmodium parasite infection that can lead to strong inflammatory immune responses in the central nervous system (CNS), accompanied by lung inflammation and anaemia.

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65

January 10, 2018 - 15:38 -- Open Access
Diletta Scaccabarozzi, Katrien Deroost, Yolanda Corbett, Natacha Lays, Paola Corsetto, Fausta Omodeo Salè, Philippe E. Van den Steen and Donatella Taramelli
Malaria Journal 2018 17:18, 9 January 2018

This study demonstrates that in C57BL/6J mice, depending on the parasite species, malaria-induced liver pathology results in different manifestations, which may contribute to the different outcomes.

Medical Condition: 

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

November 15, 2017 - 16:08 -- Open Access
Valerie M. Crowley, Kodjo Ayi, Ziyue Lu, Karen T. Liby, Michael Sporn and Kevin C. Kain
Malaria Journal 2017 16:463, 14 November 2017

These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.


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