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Determinants of uptake of intermittent preventive treatment during pregnancy: a review

November 26, 2019 - 14:41 -- Open Access
Elaine Roman, Kristin Andrejko, Katherine Wolf, Marianne Henry, Susan Youll, Lia Florey, Erin Ferenchick and Julie R. Gutman
Malaria Journal 2019 18:372, 21 November 2019

Malaria in pregnancy (MiP) contributes to devastating maternal and neonatal outcomes. Coverage of intermittent preventive treatment during pregnancy (IPTp) remains alarmingly low. Data was compiled from MiP programme reviews and performed a literature search on access to and determinants of IPTp.

Utilization of key preventive measures for pregnancy complications and malaria among women in Jimma Zone, Ethiopia

November 8, 2019 - 16:57 -- Open Access
Mariame Ouedraogo, Jaameeta Kurji, Lakew Abebe, Ronald Labonté, Sudhakar Morankar, Kunuz Haji Bedru, Gebeyehu Bulcha, Muluemebet Abera, Beth K. Potter, Marie-Hélène Roy-Gagnon & Manisha A. Kulkarni
BMC Public Health volume 19, Article number: 1443 (2019)

In Ethiopia, malaria infections and other complications during pregnancy contribute to the high burden of maternal morbidity and mortality. Preventive measures are available, however little is known about the factors influencing the uptake of maternal health services and interventions by pregnant women in Ethiopia.

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Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

September 10, 2019 - 15:34 -- Open Access
Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan
Malaria Journal 2019 18:304, 3 September 2019

Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp), on the risk of clinical malaria or parasitaemia during infancy.


Not Open Access | Proinflammatory Responses and Higher IL-10 Production by T Cells Correlate with Protection against Malaria during Pregnancy and Delivery Outcomes

March 24, 2015 - 14:17 -- NOT Open Access
Pilar Requena, Diana Barrios, Carlota Dobaño, et al.
The Journal of Immunology April 1, 2015 vol. 194 no. 7 3275-3285

We compared the frequencies of T cell subsets, including regulatory T cells, in pregnant and nonpregnant women from Papua New Guinea, a high malaria transmission area, and from Spain, a malaria-free country.

Malaria parasite detection increases during pregnancy in wild chimpanzees

November 10, 2014 - 17:38 -- Open Access
Hélène M De Nys, Sébastien Calvignac-Spencer, Christophe Boesch, Pierre Dorny, Roman M Wittig, Roger Mundry, Fabian H Leendertz
Malaria Journal 2014, 13:413 (20 October 2014)

This study provides evidence that susceptibility to malaria parasite infection increases during pregnancy, and, as shown before, in younger individuals, which points towards similar dynamics of malaria parasite infection in human and chimpanzee populations and raises questions about the effects of such infections on pregnancy outcome and offspring morbidity/mortality.

Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial

September 29, 2014 - 16:39 -- Open Access
Raquel González , Ghyslain Mombo-Ngoma, Clara Menéndez, et al.
PLoS Med 11(9): e1001733

The study arms were: (1) SP, (2) single dose MQ (15 mg/kg), and (3) split-dose MQ in the context of long lasting insecticide treated nets. There was no difference on low birth weight prevalence (primary study outcome) between groups (360/2,778 [13.0%]) for MQ group and 177/1,398 (12.7%) for SP group; risk ratio [RR], 1.02 (95% CI 0.86–1.22; p = 0.80 in the ITT analysis).

Psychosocial, behavioural and health system barriers to delivery and uptake of intermittent preventive treatment of malaria in pregnancy in Tanzania - viewpoints of service providers in Mkuranga and Mufindi districts

January 15, 2014 - 19:00 -- Open Access
Godfrey M Mubyazi and Paul Bloch
BMC Health Services Research 2014, 14:15

This paper reports from a study on the knowledge and experience of health workers (HWs) at ANC clinics regarding psychosocial, behavioural and health system barriers to IPTp-SP delivery and uptake in Tanzania.


Coverage of intermittent preventive treatment and insecticide-treated nets for the control of malaria during pregnancy in sub-Saharan Africa: a synthesis and meta-analysis of national survey data, 2009–11

November 20, 2013 - 17:20 -- Open Access
Anna Maria van Eijk, Jenny Hill, David A Larsen, Jayne Webster, Richard W Steketee, Thomas P Eisele, Feiko O ter Kuile
The Lancet Infectious Diseases, Volume 13, Issue 12, December 2013, Pages 1029-1042

We aimed to review the coverage of intermittent preventive treatment, insecticide-treated nets, and antenatal care for pregnant women in sub-Saharan Africa and to explore associations between coverage and individual and country-level factors, including the role of funding for malaria prevention.


Not Open Access | A systematic review of the impact of malaria prevention in pregnancy on low birth weight and maternal anemia

April 25, 2013 - 17:00 -- NOT Open Access
Elizabeth M. McClure, Robert L. Goldenberg, Arlene E. Dent, Steven R. Meshnick
International Journal of Gynecology & Obstetrics, Volume 121, Issue 2, May 2013, Pages 103-109


To evaluate the association between recommended preventative SP programs in pregnancy and low birth weight (LBW) and maternal anemia through available clinical trial, observational, and programmatic evaluation studies.

The Malaria in Pregnancy Library: a bibliometric review

November 11, 2012 - 07:23 -- Open Access
van Eijk AM, Hill J, Povall S, Reynolds A, Wong H, Ter Kuile FO
Malaria Journal 2012, 11:362 (30 October 2012)

The last decade has seen a dramatic increase in publications related to malaria in pregnancy, and an increasing proportion of these are publically available online.


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