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Not Open Access | Pipecolic acid, a putative mediator of the encephalopathy of cerebral malaria and the experimental model of cerebral malaria

December 28, 2021 - 20:54 -- NOT Open Access
Keswani T, Obeidallah A, Nieves E, Sidoli S, Fazzari M, Taylor T, Seydel K, Daily JP
J Infect Dis. 2021 Dec 21:jiab615

We explored a metabolic etiology of cerebral malaria (CM) coma.

Distinguishing gene flow between malaria parasite populations

December 28, 2021 - 20:48 -- Open Access
Brown TS, Arogbokun O, Buckee CO, Chang HH
PLoS Genet. 2021 Dec 20;17(12):e1009335

Measuring gene flow between malaria parasite populations in different geographic locations can provide strategic information for malaria control interventions. Multiple important questions pertaining to the design of such studies remain unanswered, limiting efforts to operationalize genomic surveillance tools for routine public health use. This report examines the use of population-level summaries of genetic divergence (FST) and relatedness (identity-by-descent) to distinguish levels of gene flow between malaria populations, focused on field-relevant questions about data size, sampling, and interpretability of observations from genomic surveillance studies.

NOT Open Access | Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent

December 7, 2021 - 21:20 -- NOT Open Access
Mourot L, Schmitt M, Mouray E, Spichty M, Florent I, Albrecht S
Bioorg Med Chem. 2021 Dec 1;51:116513

A series of new quinazolinedione derivatives have been readily synthesized and evaluated for their in vitro antiplasmodial growth inhibition activity. Most of the compounds inhibited P. falciparum FcB1 strain in the low to medium micromolar concentration.

Elucidating relationships between P.falciparum prevalence and measures of genetic diversity with a combined genetic-epidemiological model of malaria

August 25, 2021 - 16:03 -- Open Access
Hendry JA, Kwiatkowski D, McVean G
PLoS Comput Biol. 2021 Aug 19;17(8):e1009287

There is an abundance of malaria genetic data being collected from the field, yet using these data to understand the drivers of regional epidemiology remains a challenge. A key issue is the lack of models that relate parasite genetic diversity to epidemiological parameters. Classical models in population genetics characterize changes in genetic diversity in relation to demographic parameters, but fail to account for the unique features of the malaria life cycle.

NOT Open Access | Efficacy of Chininum Sulphuricum 30C against Malaria: An in vitro and in vivo Study

July 28, 2021 - 14:13 -- NOT Open Access
Suri M, Katnoria S, Walter NS, Manchanda RK, Khurana A, Nayak D, Bagai U, Kaur S
Complement Med Res. 2021 Jul 27:1-10

New effective, economical and safe antimalarial drugs are urgently needed due to the development of multi-drug-resistant strains of the parasite. Homeopathy uses ultra-diluted doses of various substances to stimulate autoregulatory and self-healing processes to cure various ailments. The aim of the study was to evaluate the in vitro and in vivo antimalarial efficacy of a homeopathic drug, Chininum sulphuricum 30C.

Assessing field performance of ultrasensitive rapid diagnostic tests for malaria: a systematic review and meta-analysis

June 9, 2021 - 07:34 -- Open Access
Celestin Danwang, Fati Kirakoya-Samadoulougou and Sekou Samadoulougou
Malaria Journal 2021 20:245, 3 June 2021

To overcome the limitations of conventional malaria rapid diagnostic tests (cRDTs) in diagnosing malaria in patients with low parasitaemia, ultrasensitive malaria rapid diagnostic tests (uRDTs) have recently been developed, with promising results under laboratory conditions. The current study is the first meta-analysis comparing the overall sensitivity, and specificity of newly developed ultrasensitive Plasmodium falciparum malaria RDT (Alere™ Ultra-sensitive Malaria Ag P. falciparum RDT) with the cRDT conducted in the same field conditions.

Anopheles ecology, genetics and malaria transmission in northern Cambodia

March 24, 2021 - 14:09 -- Open Access
Vantaux A, Riehle MM, Witkowski B, et al.
Sci Rep. 2021 Mar 19;11(1):6458

In the Greater Mekong Subregion, malaria cases have significantly decreased but little is known about the vectors or mechanisms responsible for residual malaria transmission. We analysed a total of 3920 Anopheles mosquitoes collected during the rainy and dry seasons from four ecological settings in Cambodia (villages, forested areas near villages, rubber tree plantations and forest sites). Using odor-baited traps, 81% of the total samples across all sites were collected in cow baited traps, although 67% of the samples attracted by human baited traps were collected in forest sites. Overall, 20% of collected Anopheles were active during the day, with increased day biting during the dry season.

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

March 23, 2021 - 14:35 -- Open Access
Coelho CH, Tang WK, Duffy PE, et al.
Nat Commun. 2021 Mar 19;12(1):1750

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development of P. falciparum parasites.

Not Open Access | Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion

March 17, 2021 - 09:37 -- NOT Open Access
Nguyen W, Dans MG, Sleebs BE, et al.
Eur J Med Chem. 2021 Mar 15;214:113253

The emerging resistance to combination therapies comprised of artemisinin derivatives has driven a need to identify new antimalarials with novel mechanisms of action. Central to the survival and proliferation of the malaria parasite is the invasion of red blood cells by Plasmodium merozoites, providing an attractive target for novel therapeutics. A screen of the Medicines for Malaria Venture Pathogen Box employing transgenic P. falciparum parasites expressing the nanoluciferase bioluminescent reporter identified the phenylsulfonyl piperazine class as a specific inhibitor of erythrocyte invasion.


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