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plasmodium species

Prioritization of Molecular Targets for Antimalarial Drug Discovery

September 18, 2021 - 04:12 -- Open Access
Author(s): 
Forte B, Ottilie S, Gilbert IH, et al.
Reference: 
ACS Infect Dis. 2021 Sep 15

There is a shift in antimalarial drug discovery from phenotypic screening toward target-based approaches, as more potential drug targets are being validated in Plasmodium species. Given the high attrition rate and high cost of drug discovery, it is important to select the targets most likely to deliver progressible drug candidates. In this paper, we describe the criteria that we consider important for selecting targets for antimalarial drug discovery.

Molecular Epidemiology of Plasmodium species in Conflicted Federally Administered Tribal Area (FATA) Pakistan

September 8, 2021 - 16:55 -- Open Access
Author(s): 
Nadeem MF, Khattak AA, Zeeshan N, Awan UA, Alam S, Ahmed W, Gul S, Afroz A, Sughra K, Rashid U, Khan MAU
Reference: 
Braz J Biol. 2021 Aug 27;83:e247219

Military conflicts have been significant obstacles in detecting and treating infectious disease diseases due to the diminished public health infrastructure, resulting in malaria endemicity. A variety of violent and destructive incidents were experienced by FATA (Federally Administered Tribal Areas). It was a struggle to pursue an epidemiological analysis due to continuing conflict and Talibanization. Clinical isolates were collected from Bajaur, Mohmand, Khyber, Orakzai agencies from May 2017 to May 2018. For Giemsa staining, full blood EDTA blood samples have been collected from symptomatic participants

Not Open Access | Modeling the effects of malaria on red blood cell binding at the vascular interface

August 25, 2021 - 15:37 -- NOT Open Access
Author(s): 
Clifton LA
Reference: 
Biophys J. 2021 Aug 17;120(16):3240-3241

Malaria is one of the largest diseases affecting tropical and subtropical regions, with more than 200 million cases and between 400,000 and 500,000 deaths annually, disproportionately afflicting the young, elderly, or immune compromised (1, 2). Infamously spread by infected mosquitoes, the disease is caused by several parasitic species of Plasmodium (P. falciparum, P. malariae, P. vivax, P. ovale, and P. knowlesi).

NOT Open Access | Rediscovery of Plasmodium (Huffia) huffi (Apicomplexa, Haemosporida): a lost lineage from toucans

August 10, 2021 - 18:39 -- NOT Open Access
Author(s): 
Cedrola F, Martinele I, Senra MVX, Furtado EJO, D Agosto M, Dias RJP
Reference: 
Parasitol Res. 2021 Aug 10

Literature data on toucans haemosporidians are scarce and all reports come from investigations in Brazil. Muniz et al. (Rev Bras Malariol 3: 339-356, Muniz et al., Rev Bras Malariol 3:339-356, 1951) and Muniz and Soares (Rev Bras Malar 611-617, Muniz J, Soares R de RL (1954) Nota sôbre um parasita do gênero Plasmodium encontrado no Ramphastos toco Müller, 1776, "Tucano-Açu", e diferente do Plasmodium huffi: Plasmodium pinottii n. sp. Rev Bras Malar 611 - 617.) described two Plasmodium species, P. huffi and P. pinottii, in Ramphastos toco. Later, Manwell and Sessler (J Protozol 18: 570-574, Manwell and Sessler, Malaria Parasites of Toucans J Protozol 18:570-574, 1971) established a new subspecies, P. nucleophilum toucani.

Evaluation of a novel real-time PCR assay for the detection, identification and quantification of Plasmodium species causing malaria in humans

July 14, 2021 - 11:17 -- Open Access
Author(s): 
Kim van Bergen, Toon Stuitje, Robert Akkers, Eric Vermeer, Rob Castel and Theo Mank
Reference: 
Malaria Journal 2021 20:314, 12 July 2021

The entry of PCR-based techniques into malaria diagnostics has improved the sensitivity and specificity of the detection of Plasmodium infections. It has been shown that humans are regularly infected by at least six different Plasmodium species. The MC004 real-time PCR assay for malaria diagnosis is a novel single-tube assay that has been developed for the purpose of simultaneously detecting all Plasmodium species known to infect humans, and discrimination between Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale wallikeri, Plasmodium ovale curtisi, Plasmodium knowlesi (including differentiation of three strains) and Plasmodium cynomolgi (including differentiation of three strains). Detection and identification of Plasmodium species relies on molecular beacon probe-based melting curve analysis. In addition, this assay might be used to quantify the parasitaemia of at least P. falciparum by calculating the level of parasitaemia directly from the Cq-value.

Antimalarial Activity of 2,6-Dibenzylidenecyclohexanone Derivatives

June 23, 2021 - 14:25 -- Open Access
Author(s): 
Eagon S, Hammill JT, Kiplin Guy R, et al.
Reference: 
Bioorg Med Chem Lett. 2021 Jun 19:128216

Malaria remains one of the deadliest diseases on the planet, infecting an estimated 229 million individuals in 2019 with more than 400,000 associated deaths, primarily in young children and pregnant women. Malaria is caused by Plasmodium parasite infection of the liver and blood, with P. falciparum accounting for the vast majority of deaths.

Comparison of capillary, venous and buffy coat blood samples in detecting Plasmodium species among malaria suspected patients attending at Hamusite health center. A cross-sectional study

June 23, 2021 - 13:23 -- Open Access
Author(s): 
Abeje G, Gelaye W, Alemu G
Reference: 
BMC Infect Dis. 2021 Jun 15;21(1):576

Both capillary and venous blood samples have been interchangeably used for the diagnosis of malaria in Ethiopia. However, Plasmodium parasites are thought to be more concentrated in capillary than in venous blood. Hence, selecting a sample source where parasites are more concentrated is indispensable approach in order to maximize the accuracy of blood film microscopy. Therefore, the present study aimed to compare the detection rate and the parasitemia level of Plasmodium species from conventional capillary and venous blood films, and buffy coat preparations.

NOT Open Access | Identification of a protein unique to the genus Plasmodium that contains a WD40 repeat domain and extensive low-complexity sequence

June 22, 2021 - 14:56 -- NOT Open Access
Author(s): 
Cortés GT, Beltran MMG, Gómez-Alegría CJ, Wiser MF
Reference: 
Parasitol Res. 2021 Jun 18

Proteins containing WD40 domains play important roles in the formation of multiprotein complexes. Little is known about WD40 proteins in the malaria parasite. This report contains the initial description of a WD40 protein that is unique to the genus Plasmodium and possibly closely related genera. The N-terminal portion of this protein consists of seven WD40 repeats that are highly conserved in all Plasmodium species.

Evaluation of the performance of health extension workers on malaria rapid diagnostic tests and predictor factors in Bahir Dar Zuria district, northwest Ethiopia: A cross-sectional study

April 13, 2021 - 13:17 -- Open Access
Author(s): 
Dejazmach Z, Alemu G, Yimer M, Muluneh C, Tegegne B
Reference: 
PLoS One. 2021 Apr 8;16(4):e0249708

In Ethiopia, anti-malaria treatment is initiated after parasitological confirmation using blood film microscopy at health centers and hospitals, or serological rapid diagnostic tests at health posts. At health posts, the diagnosis is performed by health extension workers using rapid diagnostic tests after little training. However, there is paucity of data about the health extension workers’ performance on rapid diagnostic tests. Hence, periodic monitoring of the performances of health extension workers on malaria rapid diagnostic tests and predicted factors plays a pivotal role for the control of malaria.

Malaria risk stratification in Colombia 2010 to 2019

March 17, 2021 - 17:17 -- Open Access
Author(s): 
Padilla-Rodríguez JC, Olivera MJ, Ahumada-Franco ML, Paredes-Medina AE
Reference: 
PLoS One. 2021 Mar 11;16(3):e0247811

Heterogeneity and focalization are the most common epidemiological characteristics of endemic countries in the Americas, where malaria transmission is moderate and low. During malaria elimination, the first step is to perform a risk stratification exercise to prioritize interventions. This study aimed to identify malaria risk strata in the ecoepidemiological regions of Colombia.

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