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To study vs to destroy

June 1, 2012 - 15:09 -- Ricardo Ataide

At the moment I'm waiting at Boston's International airport for a flight to Detroit to visit a friend, but in a couple of days I'll be back here to participate in a Malaria Eradication Course at Harvard's school of public health. I just browsed through the names and positions of the participants enrolled in the course and got a chill... Not many of us doing research will be there. 

Your signature is wanted for open access petition to the White House

May 24, 2012 - 18:37 -- Tom Olijhoek


A very important point to make about this campaign is that THE PETITION CAN BE SIGNED BY ANYONE over 13 years in age with an email address, and from all parts of the world. So by signing this petition YOU CAN MAKE A DIFFERENCE. The more signatures there are , the louder the message will be and the more chance there will be for rapid change.

If you are willing to sign the petition please go to the website access2research and follow the directives. Alternatively you can go direct to the WEthePEOPLE website.

Please sign and tell your colleagues, family, friends that they can sign too.

NOT Open Access | A critical view on antimalarial endoperoxide QSAR studies

May 17, 2012 - 14:46 -- Patrick Sampao
Teixeira RR, Carneiro JW, Araujo MT, Taranto AG.
Mini Rev Med Chem. 2012 Jun 1;12(6):562-72.

MalariaWorldThis work presents a critical view on some QSAR models, and shows that, due to lack of a rigorous selection of the descriptors entering the models, most of them are unable to accurately indicate the molecular cause of biological activity. Some reasons for the weakness of the published models are discussed.

Malaria elimination country briefings published by the UCSF Global Health Group

May 15, 2012 - 23:55 -- The Global Heal...

The Global Health Group at the University of California, San Francisco (UCSF) published 11 country briefings for the Asia Pacific which, for the first time, provide a comprehensive yet succinct overview of the history and current malaria situations in these countries.

Open Access | Regulation of Plasmodium falciparum Glideosome Associated Protein 45 (PfGAP45) Phosphorylation

May 9, 2012 - 14:50 -- Patrick Sampao
Divya Catherine Thomas, Anwar Ahmed, Tim Wolf Gilberger, Pushkar Sharma
PLoS ONE 7(4): e35855

MalariaWorldWe found that PfGAP45 is phosphorylated in response to Phospholipase C (PLC) and calcium signaling. It is phosphorylated by P. falciparum kinases Protein Kinase B (PfPKB) and Calcium Dependent Protein Kinase 1 (PfCDPK1), which are calcium dependent enzymes, at S89, S103 and S149.

Do we need to think more about gonotrophic cycles in mosquitoes and the effect they might have on parasite transmission?

May 5, 2012 - 15:32 -- Derek Charlwood

There is apparently considerable discussion about early biting shifts in mosquitoes like An. arabiensis.  (Why this might be so I hope to describe below – but be warned in a recent submission a referee questioned the number of Charlwood references quoted – I had to reply well they are really the only ones I know, and no one reads them anymore so why not – a bit like insinuating an obscure word that no one has ever read before into a text! - so you might at least know what to expect if I write anymore of them. i.e.

“Truth is not enough” part II: AAAS agrees

February 18, 2012 - 18:54 -- Mark Benedict

I blogged recently that getting the facts out about genetic engineering of mosquitoes would not be enough to persuade those who are hard anti-GM activists that they can be safely developed. I also argued that becoming an activist allowed one to abandon the bothersome constraints of truth. AAAS appears to agree with me, but have they made the right call?


Open Access | Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican Children

January 26, 2012 - 15:20 -- Patrick Sampao
Diana Quelhas, Laura Puyol, Carlota Dobano, et al.
BMC Immunology 2012, 13:5

MalariaWorldMultiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months.



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