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Malawi

Proximity of Residence to Irrigation Determines Malaria Risk and Anopheles Abundance at an Irrigated Agroecosystem in Malawi

October 23, 2021 - 12:44 -- Open Access
Author(s): 
Mangani C, Frake AN, Chipula G, Mkwaila W, Kakota T, Mambo I, Chingonda J, Mathanga D, Mzilahowa T, Zulu L, Walker E
Reference: 
Am J Trop Med Hyg. 2021 Oct 18:tpmd210390

As countries of sub-Saharan Africa expand irrigation to improve food security and foster economic growth, it is important to quantify the malaria risk associated with this process. Irrigated ecosystems can be associated with increased malaria risk, but this relationship is not fully understood. We studied this relationship at the Bwanje Valley Irrigation Scheme (800 hectares) in Malawi.

Evaluation of the Sysmex XN-31 automated analyser for blood donor malaria screening at Malawi Blood Transfusion Services

September 30, 2021 - 12:55 -- Open Access
Author(s): 
M'baya B, Mfune T, Samon A, Hwandih T, Münster M
Reference: 
Vox Sang. 2021 Sep 23

Balancing blood supply safety and sufficiency is challenging in malaria-endemic countries where the risk of transfusion-transmitted malaria (TTM) is ever-present. In support of reducing this risk, our study aimed at evaluating the performance of the Sysmex XN-31 analyser in blood donor malaria screening, as compared with current practice in Malawi.

Impact of cattle on the abundance of indoor and outdoor resting malaria vectors in southern Malawi

September 1, 2021 - 16:33 -- Open Access
Author(s): 
Monicah M. Mburu, Kennedy Zembere, Themba Mzilahowa, Anja D. Terlouw, Tumaini Malenga, Henk van den Berg, Willem Takken and Robert S. McCann
Reference: 
Malaria Journal 2021 20:353, 26 August 2021

Understanding the blood feeding preferences and resting habits of malaria vectors is important for assessing and designing effective malaria vector control tools. The presence of livestock, such as cattle, which are used as blood meal hosts by some malaria vectors, may impact malaria parasite transmission dynamics. The presence of livestock may provide sufficient blood meals for the vectors, thereby reducing the frequency of vectors biting humans. Alternatively, the presence of cattle may enhance the availability of blood meals such that infectious mosquitoes may survive longer, thereby increasing the risk of malaria transmission. This study assessed the effect of household-level cattle presence and distribution on the abundance of indoor and outdoor resting malaria vectors.

NOT Open Access | Occurrence and Distribution of Non-falciparum Malaria Parasite Species among Adolescents and Adults in Malawi

July 14, 2021 - 10:39 -- NOT Open Access
Author(s): 
Gumbo A, Topazian HM, Juliano JJ, et al.
Reference: 
J Infect Dis. 2021 Jul 9:jiab353

Plasmodium falciparum malaria dominates throughout sub-Saharan Africa, but the prevalence of P. malariae, P. ovale spp., and P. vivax increasingly contribute to infection in countries which control malaria using P. falciparum-specific diagnostic and treatment strategies.

Not Open Access | The effect of intermittent preventive treatment of malaria during pregnancy and placental malaria on infant risk of malaria

July 6, 2021 - 14:33 -- NOT Open Access
Author(s): 
Andronescu LR, Sharma A, Peterson I, Kachingwe M, Kachepa W, Liang Y, Gutman JR, Mathanga DP, Chinkhumba J, Laufer MK
Reference: 
J Infect Dis. 2021 Jul 3:jiab351

Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) provides greater protection from placental malaria than sulfadoxine-pyrimethamine (SP). Some studies suggest placental malaria alters the risk of malaria infection in infants, but few studies have quantified the effect of IPTp on infant susceptibility to malaria.

Cost of community-led larval source management and house improvement for malaria control: a cost analysis within a cluster-randomized trial in a rural district in Malawi

June 16, 2021 - 13:15 -- Open Access
Tags: 
Author(s): 
Mphatso Dennis Phiri, Robert S. McCann, Eve Worrall, et al.
Reference: 
Malaria Journal 2021 20:268, 13 June 2021

House improvement (HI) to prevent mosquito house entry, and larval source management (LSM) targeting aquatic mosquito stages to prevent development into adult forms, are promising complementary interventions to current malaria vector control strategies. Lack of evidence on costs and cost-effectiveness of community-led implementation of HI and LSM has hindered wide-scale adoption. This study presents an incremental cost analysis of community-led implementation of HI and LSM, in a cluster-randomized, factorial design trial, in addition to standard national malaria control interventions in a rural area (25,000 people), in southern Malawi.

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

May 26, 2021 - 09:35 -- Open Access
Author(s): 
Shah Z, Naung MT, Takala-Harrison S, et al.
Reference: 
PLoS Genet. 2021 May 25;17(5):e1009576

Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally.

The effect of community-driven larval source management and house improvement on malaria transmission when added to the standard malaria control strategies in Malawi: a cluster-randomized controlled trial

May 26, 2021 - 09:24 -- Open Access
Author(s): 
Robert S. McCann, Alinune N. Kabaghe, Kamija S. Phiri, et al.
Reference: 
Malaria Journal 2021 20:232, 22 May 2021

Current standard interventions are not universally sufficient for malaria elimination. The effects of community-based house improvement (HI) and larval source management (LSM) as supplementary interventions to the Malawi National Malaria Control Programme (NMCP) interventions were assessed in the context of an intensive community engagement programme.

Bayesian network models with decision tree analysis for management of childhood malaria in Malawi

May 19, 2021 - 13:54 -- Open Access
Author(s): 
Taneja SB, Douglas GP, Cooper GF, Michaels MG, Druzdzel MJ, Visweswaran S
Reference: 
BMC Med Inform Decis Mak. 2021 May 17;21(1):158

Malaria is a major cause of death in children under five years old in low- and middle-income countries such as Malawi. Accurate diagnosis and management of malaria can help reduce the global burden of childhood morbidity and mortality. Trained healthcare workers in rural health centers manage malaria with limited supplies of malarial diagnostic tests and drugs for treatment. A clinical decision support system that integrates predictive models to provide an accurate prediction of malaria based on clinical features could aid healthcare workers in the judicious use of testing and treatment. We developed Bayesian network (BN) models to predict the probability of malaria from clinical features and an illustrative decision tree to model the decision to use or not use a malaria rapid diagnostic test (mRDT).

NOT Open Access | Overdiagnosis of Malaria Illness in an Endemic Setting: A Facility-Based Surveillance Study in Malawi

May 5, 2021 - 11:26 -- NOT Open Access
Author(s): 
Peterson I, Kapito-Tembo A, Laufer M, et al.
Reference: 
Am J Trop Med Hyg. 2021 May 3:tpmd201209

In endemic settings where asymptomatic malaria infections are common, malaria infection can complicate fever diagnosis. Factors influencing fever misdiagnosis, including accuracy of malaria rapid diagnostic tests (mRDTs) and the malaria-attributable fraction of fevers (MAF), require further investigation. We conducted facility-based surveillance in Malawi, from January 2012 through December 2013 in settings of high perennial (Chikhwawa), high seasonal (Thoylo), and moderate seasonal (Ndirande) malaria transmission.

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