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Not Open Access | Cotrimoxazole versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in HIV-infected pregnant women in Bangui, Central African Republic: a Pragmatic Randomized Controlled Trial

August 25, 2021 - 15:46 -- NOT Open Access
Manirakiza A, Tondeur L, Vray M, et al.
Trop Med Int Health. 2021 Aug 18

The main objective of the MACOMBA (Maternity and Control of Malaria-HIV co-infection in Bangui) trial was to show that cotrimoxazole (CTX) is more effective than Sulphadoxine-Pyremethamine-IPTp (IPTp-SP) to prevent placental malaria infection (primary endpoint) among HIV-positive pregnant women with a CD4+ count ≥350 cells/mm3 in Bangui, CAR.

A meta-analysis on the prevalence and characteristics of severe malaria in patients with Plasmodium spp. and HIV co-infection

August 18, 2021 - 16:45 -- Open Access
Mahittikorn A, Kotepui KU, De Jesus Milanez G, Masangkay FR, Kotepui M
Sci Rep. 2021 Aug 17;11(1):16655

Co-infection with malaria and human immunodeficiency virus (HIV) increases the severity and mortality rates of both diseases. A better understanding of the effects of co-infections could help in the diagnosis, prompt treatment, prevention, and control of malarial parasites among HIV-infected patients. In this systematic review and meta-analysis, we estimated the prevalence and characteristics of severe malaria (SM) caused by co-infection with HIV.

Effectiveness of spatially targeted interventions for control of HIV, tuberculosis, leprosy and malaria: a systematic review

July 20, 2021 - 13:22 -- Open Access
Khundi M, Carpenter JR, Nliwasa M, Cohen T, Corbett EL, MacPherson P
BMJ Open. 2021 Jul 13;11(7):e044715

As infectious diseases approach global elimination targets, spatial targeting is increasingly important to identify community hotspots of transmission and effectively target interventions. We aimed to synthesise relevant evidence to define best practice approaches and identify policy and research gaps.

Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

June 1, 2021 - 12:22 -- Open Access
Holla P, Dizon B, Madi A, et al.
Sci Adv. 2021 May 26;7(22):eabg8384

Chronic infectious diseases have a substantial impact on the human B cell compartment including a notable expansion of B cells here termed atypical B cells (ABCs). Using unbiased single-cell RNA sequencing (scRNA-seq), we uncovered and characterized heterogeneities in naïve B cell, classical memory B cells, and ABC subsets. We showed remarkably similar transcriptional profiles for ABC clusters in malaria, HIV, and autoimmune diseases and demonstrated that interferon-γ drove the expansion of ABCs in malaria.

COVID-19 and Syndemic challenges in 'Battling the Big Three': HIV, TB and malaria

March 31, 2021 - 14:20 -- Open Access
Velavan TP, Meyer CG, Esen M, Kremsner PG, Ntoumi F
Int J Infect Dis. 2021 Mar 26:S1201-9712(21)00289-7

Indirect effects of the COVID-19 pandemic have the potential to seriously undermine the health system in sub-Saharan Africa with an increase in the incidences of malaria, tuberculosis (TB) and HIV infections.

NOT Open Access | Evaluation of the effects of atazanavir-ritonavir on the pharmacokinetics of lumefantrine in patients living with HIV in Lagos University Teaching Hospital, South-Western Nigeria

March 24, 2021 - 15:10 -- NOT Open Access
Usman SO, Oreagba IA, Akanmu AS, et al.
Eur J Clin Pharmacol. 2021 Mar 23

Atazanavir-ritonavir (ATVr)-based antiretroviral therapy and artemether-lumefantrine (AL) are commonly used drugs for the treatment of human immune deficiency virus (HIV) infection and malaria respectively. However, interaction of both drugs, with Cytochrome P 3A4 (CYP 3A4) isoenzyme, may spawn clinically significant pharmacokinetic interactions. This study evaluated the effects of atazanavir-ritonavir on the pharmacokinetics of lumefantrine.

Malaria and intestinal parasite co-infection and its association with anaemia among people living with HIV in Buea, Southwest Cameroon: A community-based retrospective cohort study

January 27, 2021 - 10:45 -- Open Access
Mekachie Sandie S, Sumbele IUN, Tasah MM, Kimbi HK
PLoS One. 2021 Jan 22;16(1):e0245743

Both malaria and intestinal parasites are endemic in Cameroon, and their co-infection can be of great impact on anaemia among people living with HIV (PLWH). This community-based retrospective cohort study determined the prevalence and association of infections with anaemia in PLWH and HIV-negative individuals in Buea, Cameroon from March to August 2019.

Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda

November 12, 2020 - 15:47 -- Open Access
Orishaba P, Kalyango JN, Nankabirwa JI, et al.
PLoS One. 2020 Nov 11;15(11):e0240838

Although WHO recommends cotrimoxazole (CTX) discontinuation among HIV patients who have undergone immune recovery and are living in areas of low prevalence of malaria, some countries including Uganda recommend CTX discontinuation despite having a high malaria burden. We estimated the prevalence and factors associated with malaria parasitaemia among adults living with HIV attending hospital outpatient clinic before and after discontinuation of CTX prophylaxis.


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