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NOT Open Access | "Big Three" Infectious Diseases: Tuberculosis, Malaria and HIV/AIDS

September 23, 2021 - 10:34 -- NOT Open Access
Makam P, Matsa R
Curr Top Med Chem. 2021 Sep 16

Infectious diseases have been evolving and re-evolving over the ages and causing immense misery to humans. Among them, some have been prevented and eradicated, but few are still threatening the modern era since their origin. The majority of these infectious diseases are poverty-driven, hence highly prevalent in the lower-income and mid-income countries of Africa and Asia.

Effectiveness of spatially targeted interventions for control of HIV, tuberculosis, leprosy and malaria: a systematic review

July 20, 2021 - 13:22 -- Open Access
Khundi M, Carpenter JR, Nliwasa M, Cohen T, Corbett EL, MacPherson P
BMJ Open. 2021 Jul 13;11(7):e044715

As infectious diseases approach global elimination targets, spatial targeting is increasingly important to identify community hotspots of transmission and effectively target interventions. We aimed to synthesise relevant evidence to define best practice approaches and identify policy and research gaps.

The prevalence of tuberculosis, malaria and soil-transmitted helminth infection in minority indigenous people of Southeast Asia and the Western Pacific: protocol for a systematic review and meta-analysis

July 13, 2021 - 15:10 -- Open Access
Gilmour B, Alene KA, Clarke NE, Clements ACA
Syst Rev. 2021 Jul 10;10(1):203

Infectious diseases such as tuberculosis (TB), malaria and soil-transmitted helminthiasis continue to impose a significant global health burden and socio-economic impact. Globally, minority indigenous people are disproportionately affected by poverty and are shown to experience a disparate burden of disease and poorer health outcomes than the comparative majority population. Despite these inequalities, countries rarely systematically compile epidemiological data disaggregated by ethnicity to enable the extent of the differential to be quantified.

NOT Open Access | A social network analysis of the organizations focusing on tuberculosis, malaria and pneumonia

June 1, 2021 - 12:09 -- NOT Open Access
Lopreite M, Puliga M, Riccaboni M, De Rosis S
Soc Sci Med. 2021 Jun;278:113940

In this paper,we present an original study on the use of social media data to analyze the structure of the global health networks (GHNs) relative to health organizations targeted to malaria, tuberculosis (TBC) and pneumonia as well as twitter popularity, evaluating the performance of their strategies in response to the arising health threats.

Tuberculosis and malaria in the age of COVID-19

January 5, 2021 - 15:07 -- Open Access
The Lancet Infectious Diseases
Lancet Infect Dis. 2021 Jan;21(1):1

With the world still focused on the COVID-19 pandemic and hopes for vaccine rollout, the 2020 WHO global reports on tuberculosis and malaria are timely reminders that these diseases remain two of the three deadliest infectious diseases.

Incorporating operational research in programmes funded by the Global Fund to Fight AIDS, Tuberculosis and Malaria in four sub-Saharan African countries

July 27, 2020 - 15:06 -- Open Access
Camacho S, Maher D, Kamau EM, Saric J, Segura L, Zachariah R, Wyss K
Global Health. 2020 Jul 25; 16(1):67

The current study builds upon a previous situation analysis of the extent to which grants from the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) are being utilized to support operational research and implementation research (OR/IR) activities in recipient countries. The objective of this follow-up study was to identify approaches and pathways to implement an OR component into grants to the Global Fund, in four sub-Saharan African countries. Special focus was given to the Structured Operational Research and Training IniTiative (SORT IT).

HIV, tuberculosis, and malaria: how can the impact of COVID-19 be minimised

July 20, 2020 - 15:17 -- Open Access
Sands P
Lancet Glob Health. 2020 Jul 13:S2214-109X (20)30317-X

In The   Lancet   Global   Health,   Alexandra   Hogan   and   colleagues1  report  the  findings  of  a  modelling  study  in  which  they  estimate  the  number  of  excess  deaths  from  HIV,  tuberculosis,  and  malaria  that  could  plausibly  occur   as   a   consequence   of   the   COVID-19   pandemic.  

Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Development Goal 3

April 27, 2020 - 13:55 -- Open Access
Global Burden of Disease Health Financing Collaborator Network
Lancet. 2020 Apr 23. pii: S0140-6736(20)30608-5

Sustainable Development Goal (SDG) 3 aims to “ensure healthy lives and promote well-being for all at all ages”. While a substantial effort has been made to quantify progress towards SDG3, less research has focused on tracking spending towards this goal. We used spending estimates to measure progress in financing the priority areas of SDG3, examine the association between outcomes and financing, and identify where resource gains are most needed to achieve the SDG3 indicators for which data are available.

NOT Open Access | Synthesis and efficacy of pyrvinium-inspired analogs against tuberculosis and malaria pathogens

April 15, 2020 - 14:42 -- NOT Open Access
Gaikwad VR, Karale UB, Govindarajalu G, Adhikari N, Krishna EV, Krishna VS, Misra S, Sriram D, Sijwali PS, Rode HB
Bioorganic & Medicinal Chemistry Letters, Volume 30, Issue 8, 15 April 2020, 127037

Herein, we report the synthesis and evaluation of pyrvinium-based antimalarial and antitubercular compounds. Pyrvinium is an FDA approved drug for the treatment of pinworm infection, and it has been reported to have antiparasitic and antimicrobial activities. Pyrvinium contains quinoline core coupled with pyrrole. We replaced the pyrrole with various aryl or heteroaryl substituents to generate pyrvinium analogs.

Role of secondary level laboratories in strengthening quality at primary level health facilities’ laboratories: an innovative approach to ensure accurate HIV, tuberculosis, and malaria test results in resource-limited settings

December 11, 2012 - 07:12 -- Open Access
Tsegahun Manyazewal, Antonio D. Paterniti, Robert R. Redfield, Francesco Marinucci
Diagnostic Microbiology and Infectious Disease, Volume 75, Issue 1, January 2013, Pages 55–59

Providing regular external quality assessment of primary level laboratories and timely feedback is crucial to ensure the reliability of testing capacity of the whole laboratory network.

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