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chloroquine (CQ)

Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine

September 14, 2016 - 17:28 -- Open Access
Author(s): 
Pius S. Fasinu, Babu L. Tekwani, Bharathi Avula, Narayan D. Chaurasiya, N. P. Dhammika Nanayakkara, Yan-Hong Wang, Ikhlas A. Khan and Larry A. Walker
Reference: 
Malaria Journal 2016 15:466, 13 September 2016

The metabolite-specific interactions in the current studies seem at variance with earlier reports of the dependence of PQ on CYP2D6 metabolism, and enhanced PQ anti-malarial activity/reduced toxicity in the presence of CQ/QN.

NOT Open Access | Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds

April 27, 2016 - 16:54 -- NOT Open Access
Author(s): 
Aicha Boudhar, Xiao Wei Ng, Chiew Yee Loh, Wan Ni Chia, Zhi Ming Tan, Francois Nosten, Brian W. Dymock, and Kevin S. W. Tan
Reference: 
Antimicrob. Agents Chemother. May 2016 vol. 60 no. 5 3076-3089

Resistance to antimalarial therapies, including artemisinin, has emerged as a significant challenge.

Medical Treatment: 

Effectiveness of combined chloroquine and primaquine treatment in 14 days versus intermittent single dose regimen, in an open, non-randomized, clinical trial, to eliminate Plasmodium vivax in southern Mexico

November 4, 2015 - 13:34 -- Open Access
Author(s): 
Lilia Gonzalez-Ceron, Mario Rodriguez, Marco Sandoval, Frida Santillan, Sonia Galindo-Virgen, Angel Betanzos, Angel Rosales, Olga Palomeque
Reference: 
Malaria Journal 2015, 14:426 (30 October 2015)

T14 was effective for opportune elimination of the primary blood infection and preventing relapse episodes.

Country: 
Medical Treatment: 

Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change

June 10, 2014 - 15:14 -- Open Access
Author(s): 
Tinto H, Bonkian LN, D'Alessandro U, et al.
Reference: 
Malaria Journal 2014, 13 :207 (31 May 2014)

Artemisinin derivatives are still very efficacious in Burkina Faso and DHA-PPQ seems a valuable alternative ACT.

Medical Treatment: 

NOT Open Access | In Vitro Sensitivities of Plasmodium falciparum Isolates from the China-Myanmar Border to Piperaquine and Association with Polymorphisms in Candidate Genes

March 18, 2013 - 10:04 -- NOT Open Access
Author(s): 
Mingming Hao, Dandan Jia, Liwang Cui, et al.
Reference: 
Antimicrob. Agents Chemother. April 2013 vol. 57 no. 4 1723-1729
MalariaWorld

The recent reports of resistance in Plasmodium falciparum to artemisinin derivatives and their partner drugs demand intensive studies toward understanding the molecular mechanisms of resistance.

NOT Open Access | Synthesis, characterization and antimalarial activity of quinoline–pyrimidine hybrids

December 13, 2012 - 08:22 -- NOT Open Access
Author(s): 
Stefan I. Pretorius, Wilma J. Breytenbach, Carmen de Kock, Peter J. Smith, David D. N’Da
Reference: 
Bioorganic & Medicinal Chemistry, Volume 21, Issue 1, 1 January 2013, Pages 269–277
MalariaWorld

The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity.

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