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Genetic diversity and immunogenicity of the merozoite surface protein 1 C-terminal 19-kDa fragment of Plasmodium ovale imported from Africa into China

December 1, 2021 - 20:25 -- Open Access
Xu Q, Liu S, Kassegne K, Yang B, Lu J, Sun Y, Zhong W, Zhang M, Liu Y, Zhu G, Cao J, Cheng Y
Parasit Vectors. 2021 Nov 24;14(1):583

Merozoite surface protein 1 (MSP1) plays an essential role in erythrocyte invasion by malaria parasites. The C-terminal 19-kDa region of MSP1 has long been considered one of the major candidate antigens for a malaria blood-stage vaccine against Plasmodium falciparum. However, there is limited information on the C-terminal 19-kDa region of Plasmodium ovale MSP1 (PoMSP119). This study aims to analyze the genetic diversity and immunogenicity of PoMSP119.

Intensive surveillance, rapid response and border collaboration for malaria elimination: China Yunnan’s ‘‘3 + 1’’strategy

October 23, 2021 - 18:31 -- Open Access
Jian-Wei Xu, Zu-Rui Lin, Hong-Ning Zhou, et al.
Malaria Journal 2021 20:396, 9 October 2021

Eliminating malaria and preventing re-establishment of malaria transmission in border areas requires universal coverage of malaria surveillance and a rapid response to any threats (i.e. malaria cues) of re-establishing transmission.

Care-seeking delay of imported malaria to China: Implications for improving post-travel healthcare for migrant workers

October 2, 2021 - 13:08 -- Open Access
Lu G, Cao Y, Chen Q, Zhu G, Müller O, Cao J
J Travel Med. 2021 Sep 28:taab156

Imported malaria cases continue to pose major challenges in China as well as in other countries having achieved elimination. Our study aims to identify the factors influencing the timing of care-seeking after symptom onset among migrant workers with imported malaria, in order to develop innovative interventions to improve access and provision of post-travel healthcare for returning migrants.

Epidemiological characterization of imported recurrent Plasmodium vivax and Plasmodium ovale in China, 2013-2020

August 25, 2021 - 16:59 -- Open Access
Cui Y, Zhang L, Xia Z, Zhou H, Huang F
Infect Dis Poverty. 2021 Aug 23;10(1):113

China has reached important milestones in the elimination of malaria. However, the numbers of imported recurrent cases of Plasmodium vivax and P. ovale are gradually increasing, which increases the risk of malaria re-establishment in locations where Anopheles mosquitoes exist. The aim of this study is to characterize the epidemiological profiles of imported recurrent P. vivax and P. ovale cases, quantifying the recurrence burden and guiding the development of appropriate public health intervention strategies.

Limited polymorphism in k13 gene of Plasmodium falciparum and k12 of Plasmodium vivax isolates imported from African and Asian countries between 2014 and 2019 in Hangzhou city, China

August 25, 2021 - 16:57 -- Open Access
Jin X, Zhu S, Xu W, Chen J, Ruan W, Wang X
BMC Infect Dis. 2021 Aug 21;21(1):853

Malaria causes major public health problems globally and drug resistance hinders its control and elimination. Molecular markers associated with drug resistance are considered as a beneficial tool to monitor the disease trends, evolution and distribution so as to help improve drug policy.

Malaria: elimination tale from Yunnan Province of China and new challenges for reintroduction

July 28, 2021 - 13:57 -- Open Access
Yang HL, Baloch Z, Zhou HN, et al.
Infect Dis Poverty. 2021 Jul 21;10(1):101

Eradication of infectious disease is the sanctified public health and sustainable development goal around the world.

The mechanisms of action of Plasmodium infection against cancer

July 14, 2021 - 10:30 -- Open Access
Chen X, Qin L, Hu W, Adah D
Cell Commun Signal. 2021 Jul 9;19(1):74

Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumor angiogenesis, inhibits tumor growth and metastasis, and prolongs the survival time of tumor-bearing mice. Based on these studies, three clinical trials of Plasmodium immunotherapy for advanced cancers have been approved and are ongoing in China.

NOT Open Access | Evaluation of the combination of rapid diagnostic tests and microscopy for imported malaria surveillance in Anhui Province, China

July 14, 2021 - 10:18 -- NOT Open Access
Li W, Zhang X, Feng J, Zhang T, Xu X, Jiang J, Wang S, Lyu X, Li S, Lu M
Acta Trop. 2021 Jul 9:106042

In the Anhui Province, China, efforts to interrupt the local malaria transmission were successful, with no endemic cases reported since 2014. Contrastingly, imported malaria cases are still being reported, indicating a disease reintroduction risk after years of elimination. A good surveillance system is key for avoiding the risk, detecting imported cases and possible cases associated with local transmission early. Therefore, rapid diagnostic tests (RDTs) were combined with microscopy to strengthen malaria surveillance in the province. Herein, we aimed to evaluate the efficacy of this surveillance strategy.

China declared malaria-free: a milestone in the world malaria eradication and Chinese public health

July 14, 2021 - 09:59 -- Open Access
Zhou XN
Infect Dis Poverty. 2021 Jul 12;10(1):98

On 30 June 2021, the World Health Organization announced that the People’s Republic of China (PR China) had been certified malaria-free, after a field mission in PR China in May 2021 by an independent certification panel. This award of malaria-free certification is a major milestone both for the world history in malaria eradication programme and for the Chinese public health history.

NOT Open Access | Increasing proportions of relapsing parasite species among imported malaria in China's Guangxi Province from Western and Central Africa

June 30, 2021 - 13:01 -- NOT Open Access
Liu P, Shen L, Yang Z, et al.
Travel Med Infect Dis. 2021 Jun 21;43:102130

Travel-related malaria in non-endemic areas returning from endemic areas presents important challenges to diagnosis and treatment. Imported malaria to newly malaria-free countries poses further threats of malaria re-introduction and potential resurgence. For those traveling to places with high Plasmodium falciparum prevalence, prophylaxis against this parasite is recommended, whereas causal prophylaxis against relapsing malaria is often overlooked.


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