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NOT Open Access | YihA GTPases localize to the apicoplast and mitochondrion of the malaria parasite and interact with LSU of organellar ribosomes

February 22, 2020 - 16:34 -- NOT Open Access
Gupta A, Gupta K, Habib S
Molecular and Biochemical Parasitology, Volume 236, March 2020, 111265

The YihA TRAFAC GTPases are critical for late-stage assembly of the ribosomal large subunit (LSU). In order to explore biogenesis of the reduced organellar ribosomes of the malaria parasite, we identified three nuclear-encoded homologs of YihA in Plasmodium falciparum. PfYihA1 targeted to the parasite apicoplast, PfYihA2 to the mitochondrion, and PfYihA3 was found in both the apicoplast and cytosol. The three PfYihA, expressed as recombinant proteins, were active GTPases and interacted with surrogate E. coli ribosomes in a nucleotide-independent manner.

NOT Open Access | Crystallization and preliminary X-ray analysis of the Plasmodium falciparum apicoplast DNA polymerase

March 17, 2015 - 14:40 -- NOT Open Access
Morgan E. Milton, Jun-yong Choe, Richard B. Honzatko and Scott W. Nelson
Acta Crystallographica Section F, Volume 71, Issue 3, pages 333–337, March 2015

The apicoplast contains a genome that undergoes replication and repair through the action of a replicative polymerase (apPOL). apPOL has no direct orthologs in mammalian polymerases and is therefore an attractive antimalarial drug target.

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