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Prevalence and risk factors associated with asymptomatic malaria among school children: repeated cross-sectional surveys of school children in two ecological zones in Ghana

September 23, 2021 - 10:39 -- Open Access
Mensah BA, Myers-Hansen JL, Obeng Amoako E, Opoku M, Abuaku BK, Ghansah A
BMC Public Health. 2021 Sep 17;21(1):1697

Asymptomatic Plasmodium infections significantly drive malaria transmission and impact control and elimination strategies, but are largely uncharacterized. We investigated the prevalence and risk factors of asymptomatic malaria infections to inform malaria control strategies in Ghana.

Microsporidia MB is found predominantly associated with Anopheles gambiae s.s and Anopheles coluzzii in Ghana

September 23, 2021 - 08:25 -- Open Access
Akorli J, Akorli EA, Tetteh SNA, Amlalo GK, Opoku M, Pwalia R, Adimazoya M, Atibilla D, Pi-Bansa S, Chabi J, Dadzie SK
Sci Rep. 2021 Sep 20;11(1):18658

A vertically transmitted microsporidian, Microsporidia MB, with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa. To demonstrate its range of incidence, archived DNA samples from 7575 Anopheles mosquitoes collected from Ghana were screened. MB prevalence was observed at 1.8%. An. gambiae s.s constituted 87% of positive mosquitoes while the remaining were from An. coluzzii.

Health-seeking behaviour and cost of fever treatment to households in a malaria-endemic setting of northern Ghana: a cross-sectional study

September 18, 2021 - 04:17 -- Open Access
Dalaba MA, Welaga P, Akweongo P, et al.
BMJ Open. 2021 Sep 13;11(9):e05222

To examine the health-seeking behaviour and cost of fever treatment to households in Ghana.

Comparison of the impact of allelic polymorphisms in PfAMA1 on the induction of T Cell responses in high and low malaria endemic communities in Ghana

September 18, 2021 - 04:10 -- Open Access
Ebenezer A. Ofori, John K. A. Tetteh, Augustina Frimpong, Harini Ganeshan, Maria Belmonte, Bjoern Peters, Eileen Villasante, Martha Sedegah, Michael F. Ofori and Kwadwo A. Kusi
Malaria Journal 2021 20:367, 10 September 2021

Malaria eradication requires a combined effort involving all available control tools, and these efforts would be complemented by an effective vaccine. The antigen targets of immune responses may show polymorphisms that can undermine their recognition by immune effectors and hence render vaccines based on antigens from a single parasite variant ineffective against other variants. This study compared the influence of allelic polymorphisms in Plasmodium falciparum apical membrane antigen 1 (PfAMA1) peptide sequences from three strains of P. falciparum (3D7, 7G8 and FVO) on their function as immunodominant targets of T cell responses in high and low malaria transmission communities in Ghana.

Partial indoor residual spraying with pirimiphos-methyl as an effective and cost-saving measure for the control of Anopheles gambiae s.l. in northern Ghana

September 15, 2021 - 11:52 -- Open Access
Coleman S, Yihdego Y, Seyoum A, et al.
Sci Rep. 2021 Sep 10;11(1):18055

The scale up of indoor residual spraying (IRS) and insecticide treated nets have contributed significantly to global reductions in malaria prevalence over the last two decades. However, widespread pyrethroid resistance has necessitated the use of new and more expensive insecticides for IRS. Partial IRS with pirimiphos-methyl in experimental huts and houses in a village-wide trial was evaluated against Anopheles gambiae s.l. in northern Ghana.

Analysis of contamination in cluster randomized trials of malaria interventions

September 15, 2021 - 11:26 -- Open Access
Multerer L, Glass TR, Vanobberghen F, Smith T
Trials. 2021 Sep 10;22(1):613

In cluster randomized trials (CRTs) of interventions against malaria, mosquito movement between households ultimately leads to contamination between intervention and control arms, unless they are separated by wide buffer zones.

NOT Open Access | Immunological, haematological, and clinical attributes of rural and urban malaria: a case-control study in Ghana

September 8, 2021 - 16:04 -- NOT Open Access
Acheampong DO, Adu P, Ampomah P, Duedu KO, Aninagyei E
J Parasit Dis. 2021 Sep;45(3):806-816

To compare clinical presentations, haematological and immunological parameters in urban and rural malaria patients. Clinically suspected malaria patients, resident in either rural or urban communities, were selected from seven health facilities in the Greater Accra region of Ghana. For each suspected malaria patient, parasites were detected microscopically and quantified subsequently. In each study site, an equal number of cases and age-matched controls were selected. In both cases and controls, clinical presentations, nutritional status, haematological, and immunological parameters were profiled.

A predictive model, and predictors of under-five child malaria prevalence in Ghana: How do LASSO, Ridge and Elastic net regression approaches compare

September 1, 2021 - 17:26 -- Open Access
Aheto JMK, Duah HO, Agbadi P, Nakua EK
Prev Med Rep. 2021 Jun 27;23:101475

Malaria is among the leading causes of mortality and morbidity among children in Ghana. Therefore, identifying the predictors of malaria prevalence in children under-five is among the priorities of the global health agenda. In Ghana, the paradigm shifts from using traditional statistics to machine learning techniques to identifying predictors of malaria prevalence are scarce.

Burden of malaria in children under five and caregivers' health-seeking behaviour for malaria-related symptoms in artisanal mining communities in Ghana

August 25, 2021 - 16:37 -- Open Access
Dao F, Djonor SK, Ayin CT, Adu GA, Sarfo B, Nortey P, Akuffo KO, Danso-Appiah A
Parasit Vectors. 2021 Aug 21;14(1):418

Artisanal mining creates enabling breeding ground for the vector of malaria parasites. There is paucity of data on the effects of artisanal mining on malaria. This study assessed burden of malaria and caregivers’ health-seeking behaviour for children under five in artisanal mining communities in East Akim District in Ghana.

Co-creation and prototyping of an intervention focusing on health literacy in management of malaria at community-level in Ghana

August 10, 2021 - 18:05 -- Open Access
Boateng MA, Agyei-Baffour E, Angel S, Asare O, Prempeh B, Enemark U
Res Involv Engagem. 2021 Aug 5;7(1):55

Collaborating with end-users to develop interventions tailored to fit unique circumstances is proposed as a way to improve relevance and effectiveness of an intervention. This study used a local needs driven approach to develop a health literacy intervention for caregivers in Ghana concerning management of malaria in children under 5 years.


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