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Effects of insemination and blood-feeding on locomotor activity of wild-derived females of the malaria mosquito Anopheles coluzzii

September 8, 2021 - 17:21 -- Open Access
Traoré AS, Porciani A, Moiroux N, Dabiré RK, Simard F, Costantini C, Mouline K
Parasit Vectors. 2021 Sep 7;14(1):457

Behavioural shifts in the canonical location and timing of biting have been reported in natural populations of anopheline malaria vectors following the implementation of insecticide-based indoor vector control interventions. These modifications increase the likelihood of human-vector contact and allow mosquitoes to avoid insecticides, both conditions being favourable to residual transmission of the malarial parasites. The biting behaviour of mosquitoes follows rhythms that are under the control of biological clocks and environmental conditions, modulated by physiological states. In this work we explore modifications of spontaneous locomotor activity expressed by mosquitoes in different physiological states to highlight phenotypic variability associated to circadian control that may contribute to explain residual transmission in the field.

A global assessment of surveillance methods for dominant malaria vectors

August 4, 2021 - 12:14 -- Open Access
van de Straat B, Russell TL, Staunton KM, Sinka ME, Burkot TR
Sci Rep. 2021 Jul 28;11(1):15337

The epidemiology of human malaria differs considerably between and within geographic regions due, in part, to variability in mosquito species behaviours. Recently, the WHO emphasised stratifying interventions using local surveillance data to reduce malaria.

NOT Open Access | Genome-environment Association Methods Comparison Supports Omnigenic Adaptation to Ecological Niche in Malaria Vector Mosquitoes

July 28, 2021 - 12:58 -- NOT Open Access
DeRaad DA, Cobos ME, Alkishe A, Ashraf U, Mensah AK, Nuñez-Penichet C, Peterson AT
Mol Ecol. 2021 Jul 26. doi: 10.1111/mec.16094

The concept of a fundamental ecological niche is central to questions of geographic distribution, population demography, species conservation, and evolutionary potential. But robust inference of genomic regions associated with evolutionary adaptation to particular environmental conditions remains difficult due to the myriad of potential confounding processes that can generate heterogeneous patterns of variation across the genome.

An Ecologically Framed Comparison of The Potential for Zoonotic Transmission of Non-Human and Human-Infecting Species of Malaria Parasite

July 7, 2021 - 15:02 -- Open Access
Clark NF, Taylor-Robinson AW
Yale J Biol Med. 2021 Jun 30;94(2):361-373

The threats, both real and perceived, surrounding the development of new and emerging infectious diseases of humans are of critical concern to public health and well-being. Among these risks is the potential for zoonotic transmission to humans of species of the malaria parasite, Plasmodium, that have been considered historically to infect exclusively non-human hosts.

Ivermectin treatment in humans for reducing malaria transmission

June 30, 2021 - 09:40 -- Open Access
de Souza DK, Thomas R, Bradley J, Leyrat C, Boakye DA, Okebe J
Cochrane Database Syst Rev. 2021 Jun 29;6:CD013117

Malaria is transmitted through the bite of Plasmodium‐infected adult female Anopheles mosquitoes. Ivermectin, an anti‐parasitic drug, acts by killing mosquitoes that are exposed to the drug while feeding on the blood of people (known as blood feeds) who have ingested the drug. This effect on mosquitoes has been demonstrated by individual randomized trials. This effect has generated interest in using ivermectin as a tool for malaria control.

Safety and Tolerability of Mosquito-Bite Induced Controlled Human Infection with P. vivax in Malaria-Naive Study Participants - Clinical Profile and Utility of Molecular Diagnostic Methods

June 30, 2021 - 09:34 -- Open Access
Kamau E, Bennett JW, Yadava A
J Infect Dis. 2021 Jun 23:jiab332

Plasmodium vivax controlled-human-malaria-infection (PvCHMI) is an important tool for the evaluation of drugs, vaccines and pathologies associated with this parasite. However, there is little data on its safety due to the limited number of PvCHMIs performed to-date.

Mosquito metallomics reveal copper and iron as critical factors for Plasmodium infection

June 29, 2021 - 14:13 -- Open Access
Maya-Maldonado K, Cardoso-Jaime V, González-Olvera G, Osorio B, Recio-Tótoro B, Manrique-Saide P, Rodríguez-Sánchez IP, Lanz-Mendoza H, Missirlis F, Hernández-Hernández FC
PLoS Negl Trop Dis. 2021 Jun 23;15(6):e0009509

Iron and copper chelation restricts Plasmodium growth in vitro and in mammalian hosts. The parasite alters metal homeostasis in red blood cells to its favor, for example metabolizing hemoglobin to hemozoin. Metal interactions with the mosquito have not, however, been studied. Here, we describe the metallomes of Anopheles albimanus and Aedes aegypti throughout their life cycle and following a blood meal. Consistent with previous reports, we found evidence of maternal iron deposition in embryos of Ae. aegypti, but less so in An. albimanus.

NOT Open Access | Functional human IgA targets a conserved site on malaria sporozoites

June 29, 2021 - 14:02 -- NOT Open Access
Tan J, Cho H, Crompton PD, et al.
Sci Transl Med. 2021 Jun 23;13(599):eabg2344

Immunoglobulin (Ig)A antibodies play a critical role in protection against mucosal pathogens. However, the role of serum IgA in immunity to nonmucosal pathogens, such as Plasmodium falciparum, is poorly characterized, despite being the second most abundant isotype in blood after IgG. Here, we investigated the circulating IgA response in humans to P. falciparum sporozoites that are injected into the skin by mosquitoes and migrate to the liver via the bloodstream to initiate malaria infection. We found that circulating IgA was induced in three independent sporozoite-exposed cohorts: individuals living in an endemic region in Mali, malaria-naïve individuals immunized intravenously with three large doses of irradiated sporozoites, and malaria-naïve individuals exposed to a single controlled mosquito bite infection.

Dissection-independent production of Plasmodium sporozoites from whole mosquitoes

June 23, 2021 - 13:47 -- Open Access
Blight J, Sala KA, Baum J, et al.
Life Sci Alliance. 2021 Jun 16;4(7):e202101094

Progress towards a protective vaccine against malaria remains slow. To date, only limited protection has been routinely achieved following immunisation with either whole-parasite (sporozoite) or subunit-based vaccines. One major roadblock to vaccine progress, and to pre-erythrocytic parasite biology in general, is the continued reliance on manual salivary gland dissection for sporozoite isolation from infected mosquitoes.

Mosquitoes (Diptera: Culicidae) from Villages and Forest Areas of Rural Communes in Khanh Hoa and Binh Phuoc Provinces, Vietnam

June 22, 2021 - 14:19 -- Open Access
Vu NS, Hertz JC, Martin NJ, Tran TC, Fiorenzano JM, Tran PV, Nguyen HV, Dang AD, Tran DN, Motoki MT
J Med Entomol. 2021 Jun 18:tjab106

This study presents the diversity of mosquitoes collected from communes, endemic with malaria and dengue, located in Khanh Hoa and Binh Phuoc Provinces, Vietnam. A total of 10,288 mosquitoes were collected in the village and forested sites using standard larval dippers, cow-baited traps, ultra-violet light traps, and mechanical aspirators. Mosquito taxa were identified morphologically and species complexes/groups were further characterized molecularly.


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