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Identification of a Novel Series of Potent Organosilicon Mosquito Repellents

December 4, 2021 - 20:42 -- Open Access
Kulkarni AS, Ramesh R, Walia S, Sayyad SI, Gathalkar GB, Balamkundu S, Joshi M, Sen A, Reddy DS
ACS Omega. 2021 Nov 12;6(46):31236-31243

Mosquito control by personal protection is one of the most efficient ways of curtailing deadly diseases such as malaria and dengue with the potential to save millions of lives per year. DEET (N,N-diethyl-3-methyl benzamide) is currently considered as the gold standard for mosquito repellents, being used for the past several decades. Control by DEET, however, is being threatened by emerging resistance among mosquitoes.

An update on the mosquito fauna and mosquito-borne diseases distribution in Cameroon

October 13, 2021 - 12:32 -- Open Access
Bamou R, Mayi MPA, Djiappi-Tchamen B, Nana-Ndjangwo SM, Nchoutpouen E, Cornel AJ, Awono-Ambene P, Parola P, Tchuinkam T, Antonio-Nkondjio C
Parasit Vectors. 2021 Oct 11;14(1):527

The expansion of mosquito-borne diseases such as dengue, yellow fever, and chikungunya in the past 15 years has ignited the need for active surveillance of common and neglected mosquito-borne infectious diseases. The surveillance should be designed to detect diseases and to provide relevant field-based data for developing and implementing effective control measures to prevent outbreaks before significant public health consequences can occur.

Early warning systems (EWSs) for chikungunya, dengue, malaria, yellow fever, and Zika outbreaks: What is the evidence? A scoping review

September 23, 2021 - 10:36 -- Open Access
Hussain-Alkhateeb L, Rivera Ramírez T, Kroeger A, Gozzer E, Runge-Ranzinger S
PLoS Negl Trop Dis. 2021 Sep 16;15(9):e0009686

Early warning systems (EWSs) are of increasing importance in the context of outbreak-prone diseases such as chikungunya, dengue, malaria, yellow fever, and Zika. A scoping review has been undertaken for all 5 diseases to summarize existing evidence of EWS tools in terms of their structural and statistical designs, feasibility of integration and implementation into national surveillance programs, and the users’ perspective of their applications.

Malaria and dengue in Hodeidah city, Yemen: High proportion of febrile outpatients with dengue or malaria, but low proportion co-infected

June 30, 2021 - 09:43 -- Open Access
Abdul-Ghani R, Mahdy MAK, Alkubati S, Al-Mikhlafy AA, Alhariri A, Das M, Dave K, Gil-Cuesta J
PLoS One. 2021 Jun 25;16(6):e0253556

The emergence of dengue in malaria-endemic countries with limited diagnostic resources, such as Yemen, can be problematic because presumptive treatment of febrile cases as being malaria is a common practice. Co-infections with dengue and malaria are often overlooked and misdiagnosed as being a mono-infection because of clinical similarities. In Hodeidah city, Yemen, the capacity to conduct the diagnosis can be aggravated by the war context. To assess the magnitude of the problem, we determined the proportions of malaria, dengue and co-infection in relation to clinical characteristics among febrile outpatients.

Management of insecticides for use in disease vector control: Lessons from six countries in Asia and the Middle East

May 19, 2021 - 14:02 -- Open Access
Henk van den Berg, Raman Velayudhan, Rajpal S. Yadav
PLoSNegl Trop Dis15(4):e0009358

Interventions to control the vectors of human diseases, notably malaria, leishmaniasis and dengue, have relied mainly on the action of chemical insecticides. However, concerns have been raised regarding the management of insecticides in vector-borne disease-endemic countries. Our study aimed to analyze how vector control insecticides are managed in selected countries to extract lessons learned.

NOT Open Access | Association of undernutrition with dengue, malaria and acute diarrhea among children in a Thai-Myanmar border

May 18, 2021 - 13:33 -- NOT Open Access
Kurahashi Y, Hattasingh W, Chatchen S, Yingtaweesak T, Sirivichayakul C
J Public Health (Oxf). 2021 May 17:fdab146

Undernutrition has been shown to be associated with various infectious diseases. However, the recent improvement in nutritional status and management for infectious diseases worldwide necessitates the re-evaluation of this association.

Enhanced passive surveillance dengue infection among febrile children: Prevalence, co-infections and associated factors in Cameroon

April 20, 2021 - 15:08 -- Open Access
Nkenfou CN, Fainguem N, Dongmo-Nguefack F, Yatchou LG, Kameni JJK, Elong EL, Samie A, Estrin W, Koki PN, Ndjolo A
PLoS Negl Trop Dis. 2021 Apr 16;15(4):e0009316

Dengue virus (DENV) causes a spectrum of diseases ranging from asymptomatic, mild febrile to a life-threatening illness: dengue hemorrhagic fever. The main clinical symptom of dengue is fever, similar to that of malaria. The prevalence of dengue virus infection, alone or in association with other endemic infectious diseases in children in Cameroon is unknown.

NOT Open Access | Investigation of Dengue-Malaria co-infection among febrile patients consulting at Ngaoundere Regional Hospital, Cameroon

December 16, 2020 - 12:51 -- NOT Open Access
Galani BRT, Mapouokam DW, Nemg Simo FB, Mohamadou H, Djamen Chuisseu PD, Njintang NY, Moundipa PF
J Med Virol. 2020 Dec 15

This study aimed at evaluating the seroprevalence of dengue among malarious patients consulting at the Ngaoundere regional hospital. During 2 months and a half, 174 participants were recruited and their blood samples were screened for Plasmodium spp and then for Dengue virus (DENV) infection using rapid diagnostic tests. Also, hematological parameters were measured using a hematology autoanalyzer. Among patients tested, 134 (77.01%) were malaria-positive, and 12/134 (8.95%) were co-infected. In this population, 8/12 (66.67%) were only anti-DENV IgM-positive, 3/12 (25%) were both NS1 and anti-DENV IgM positive, and 1/12 (8.33%) were anti-DENV IgG-positive.

Not Open Access | Dengue and Plasmodium falciparum Coinfection With Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Boy: A Clinical Conundrum

December 16, 2020 - 09:35 -- NOT Open Access
Srivatsav S, Mahalingam S, Ramineni P, Manya S
J Pediatr Hematol Oncol. 2020 Dec 9

Hemophagocytic lymphohistiocytosis (HLH) is a multisystem disease wherein there is an exaggerated immune system activation following a trigger such as infection, malignancy, or autoimmune diseases. Here we report a case of a 3-year-old boy who presented to us with fever, was diagnosed with dengue fever, and treatment started for the same.

New Mosquitocide Derived From Volcanic Rock

August 22, 2020 - 09:39 -- Open Access
Deguenon JM, Riegel C, Cloherty-Duvernay ER, Chen K, Stewart DA, Wang B, Gittins D, Tihomirov L, Apperson CS, McCord MG, Roe RM
J Med Entomol. 2020 Aug 18:tjaa141

Malaria, dengue, yellow fever, and the Zika and West Nile Viruses are major vector-borne diseases of humans transmitted by mosquitoes. According to the World Health Organization, over 80% of the world's population is at risk of contacting these diseases. Insecticides are critical for mosquito control and disease prevention, and insect insecticide resistance is on the increase; new alternatives with potentially different modes of action from current chemistry are needed.


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