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Malaria-Resistant Mosquitoes (Diptera: Culicidae); The Principle is Proven, But Will the Effectors Be Effective

May 25, 2021 - 13:53 -- Open Access
Adelman ZN, Kojin BB
J Med Entomol. 2021 May 21:tjab090

Over the last few decades, a substantial number of anti-malarial effector genes have been evaluated for their ability to block parasite infection in the mosquito vector. While many of these approaches have yielded significant effects on either parasite intensity or prevalence of infection, just a few have been able to completely block transmission.

Multimodal synergisms in host stimuli drive landing response in malaria mosquitoes

April 6, 2021 - 13:50 -- Open Access
Carnaghi M, Belmain SR, Hopkins RJ, Hawkes FM
Sci Rep. 2021 Apr 1;11(1):7379

Anopheles mosquitoes transmit malaria, which affects one-fifth of the world population. A comprehensive understanding of mosquito behaviour is essential for the development of novel tools for vector control and surveillance. Despite abundant research on mosquito behaviour, little is known on the stimuli that drive malaria vectors during the landing phase of host-seeking.

A novel fungal metabolite inhibits Plasmodium falciparum transmission and infection

March 26, 2021 - 15:59 -- Open Access
Niu G, Wang X, Hao Y, Kandel S, Niu G, Raptis RG, Li J
Parasit Vectors. 2021 Mar 24;14(1):177

Malaria transmission depends on infected mosquitoes and can be controlled by transmission-blocking drugs. The recently discovered FREP1-mediated malaria transmission pathway is an excellent target to screen drugs for limiting transmission.

Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito

August 5, 2020 - 16:24 -- Open Access
Lantero E, Fernandes J, Aláez-Versón CR, Gomes J, Silveira H, Nogueira F, Fernàndez-Busquets X
Biomolecules. 2020 Aug 1;10(8):E1136

Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes.

Spatial–temporal distribution of Anopheles larval habitats in Uganda using GIS/remote sensing technologies

November 15, 2018 - 20:43 -- Open Access
Ryan Tokarz and Robert J. Novak
Malaria Journal 2018 17:420

The findings show that the spatial outcomes of productive habitats can be made starkly apparent through initial habitat modelling and resulting time-series output. However, mosquito control resources are often limited and it is at this point that the Local Moran’s I statistics demonstrates its value. 

Targeting male mosquito mating behaviour for malaria control

July 9, 2015 - 15:39 -- Open Access
Diabate A, Tripet F
Parasites & Vectors 2015, 8 :347 (26 June 2015)

Here, we argue that recent and continuing progress in our understanding of male mating biology is instrumental in the implementation of new approaches based on the release of either conventional sterile or genetically engineered males. 

Not Open Access | Persistent oscillations and backward bifurcation in a malaria model with varying human and mosquito populations: implications for control

May 12, 2015 - 15:54 -- NOT Open Access
Calistus N. Ngonghala, Miranda I. Teboh-Ewungkem, Gideon A. Ngwa
Journal of Mathematical Biology, June 2015, Volume 70, Issue 7, pp 1581-1622

Our model considers disease-related deaths, asymptomatic immune humans who are also infectious, as well as mosquito demography, reproduction and feeding habits.

Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection

July 23, 2013 - 15:58 -- Open Access
Matthew B. Laurens, Peter Billingsley, Kirsten E. Lyke, et al.
PLoS ONE 8(7): e689

Here, we report results from a subsequent CHMI study using 3 PfSPZ-infected mosquitoes reared aseptically to validate the initial clinical trial. We also compare results of safety, tolerability, and transmission dynamics in participants undergoing CHMI using 3 PfSPZ-infected mosquitoes reared aseptically to published studies of CHMI using 5 mosquitoes.

Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito

April 18, 2013 - 14:52 -- Open Access
Ngwa CJ, Scheuermayer M, Mair GR, Kern S, Brügl T, Wirth CC, Aminake MN, Wiesner J, Fischer R, ilcinskas AV, Pradel G
BMC Genomics 2013, 14:256 (15 April 2013)

The transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by dormant sexual precursor cells, the gametocytes, which become activated in the mosquito midgut. 

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