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plasmodium parasites

Progress in the Development of Subunit Vaccines against Malaria

July 15, 2020 - 14:55 -- Open Access
Author(s): 
Skwarczynski M, Chandrudu S, Rigau-Planella B, Islam MT, Cheong YS, Liu G, Wang X, Toth I, Hussein WM
Reference: 
Vaccines (Basel). 2020 Jul 10;8(3):E373

Malaria is a life-threatening disease and one of the main causes of morbidity and mortality in the human population. The disease also results in a major socio-economic burden. The rapid spread of malaria epidemics in developing countries is exacerbated by the rise in drug-resistant parasites and insecticide-resistant mosquitoes. At present, malaria research is focused mainly on the development of drugs with increased therapeutic effects against Plasmodium parasites.

NOT Open Access | Molecular and pathological investigations of Plasmodium parasites infecting striped forest whiptail lizards (Kentropyx calcarata) in Brazil

June 23, 2020 - 15:23 -- NOT Open Access
Author(s): 
Ferreira FC, Alves LGM, Jager GB, Franzini LD, Mesquita DO, Díaz-Delgado J, Catão-Dias JL, Braga ÉM
Reference: 
Parasitol Res. 2020 Jun 17

The genus Plasmodium (Plasmodiidae) ranks among the most widespread intracellular protozoan parasites affecting a wide range of mammals, birds, and reptiles. Little information is available about lizard malaria parasites in South America, and the pathological features of the resulting parasitoses remain unknown or poorly understood. To partially fill in these gaps, we conducted blood smear analysis, molecular detection, and phylogenetic and pathological investigations in lizards inhabiting an Atlantic Forest fragment in Paraiba, Brazil.

Deep Learning Based Automatic Malaria Parasite Detection from Blood Smear and its Smartphone Based Application

May 25, 2020 - 07:58 -- Open Access
Author(s): 
Fuhad KMF, Tuba JF, Sarker MRA, Momen S, Mohammed N, Rahman T
Reference: 
Diagnostics (Basel). 2020 May 20; 10(5):E329

Malaria is a life-threatening disease that is spread by the Plasmodium parasites. It is detected by trained microscopists who analyze microscopic blood smear images. Modern deep learning techniques may be used to do this analysis automatically. The need for the trained personnel can be greatly reduced with the development of an automatic accurate and efficient model.

Cholesterol-dependent enrichment of understudied erythrocytic stages of human Plasmodium parasites

March 18, 2020 - 14:34 -- Open Access
Author(s): 
Brown AC, Moore CC, Guler JL
Reference: 
Sci Rep. 2020 Mar 12;10(1):4591

For intracellular pathogens, the host cell provides needed protection and nutrients. A major challenge of intracellular parasite research is collection of high parasite numbers separated from host contamination. This situation is exemplified by the malaria parasite, which spends a substantial part of its life cycle inside erythrocytes as rings, trophozoites, and schizonts, before egress and reinvasion.

NOT Open Access | Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites

February 17, 2020 - 12:07 -- NOT Open Access
Author(s): 
Singh L, Fontinha D, Francisco D, Mendes AM, Prudêncio M, Singh K
Reference: 
J Med Chem. 2020 Feb 3.

Ivermectin is a powerful endectocide, which reduces the incidence of vector-borne diseases. Besides its strong insecticidal effect on mosquito vectors of the disease, ivermectin inhibits Plasmodium falciparum sporogonic and blood stage development and impairs Plasmodium berghei development inside hepatocytes, both in vitro and in vivo.

Nedd8 hydrolysis by UCH proteases in Plasmodium parasites

November 5, 2019 - 12:51 -- Open Access
Author(s): 
Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B. Ascher, Bethany Mason, Gerbrand J. van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus C. S. Lee, Katerina Artavanis-Tsakonas
Reference: 
PLoS Pathog 15(10): e1008086.

Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a vaccine make finding new chemotherapeutic strategies imperative.

Medical Treatment: 

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

March 6, 2019 - 13:26 -- Open Access
Author(s): 
Jasmin Akter, David S. Khoury, Ashraful Haque, et al.
Reference: 
PLoS Pathog 15(2): e1007599

Plasmodium parasites invade and multiply inside red blood cells (RBC).

NOT Open Access | De novo synthesis of thiamine (vitamin B1) is the ancestral state in Plasmodium parasites – evidence from avian haemosporidians

July 19, 2018 - 16:55 -- NOT Open Access
Author(s): 
Olof Hellgren, Staffan Bensch, Elin Videvall
Reference: 
Parasitology, Volume 145 / Issue 8, July 2018, pp 1084 – 1089

Parasites often have reduced genomes as their own genes become redundant when utilizing their host as a source of metabolites, thus losing their own de novo production of metabolites.

NOT Open Access | Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity

March 28, 2018 - 15:39 -- NOT Open Access
Author(s): 
Dora Posfai, Amber L. Eubanks, Emily R. Derbyshire, et al.
Reference: 
Antimicrob. Agents Chemother. April 2018 vol. 62 no. 4 e01799-17

Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics.

NOT Open Access | Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds

November 30, 2017 - 14:51 -- NOT Open Access
Author(s): 
Junjun Tian, Leen Vandermosten, Steve Peigneur, Lien Moreels, Jef Rozenski, Jan Tytgat, Piet Herdewijn, Philippe E. Van den Steen, Steven De Jonghe
Reference: 
Bioorganic & Medicinal Chemistry, Volume 25, Issue 24, 15 December 2017, Pages 6332-6344

Astemizole is a H1-antagonist endowed with antimalarial activity, but has hERG liabilities.

Medical Treatment: 

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