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Treatment

Health workers readiness and practice in malaria case detection and appropriate treatment: a meta-analysis and meta-regression

November 18, 2021 - 11:33 -- Open Access
Author(s): 
Hosein Azizi, Reza Majdzadeh, Ayat Ahmadi, Elham Davtalab Esmaeili, Behrouz Naghili and Mohammad Ali Mansournia
Reference: 
Malaria Journal 2021 20:420, 24 October 2021

Health workers (HWs) appropriate malaria case management includes early detection and prompt treatment with appropriate anti-malarial drugs. Subsequently, HWs readiness and practice are considered authentic evidence to measure the health system performance regarding malaria control programme milestones and to issue malaria elimination certification. There is no comprehensive evidence based on meta-analysis, to measure the performance of HWs in case management of malaria. This study aimed to evaluate HWs performance in early malaria case detection (testing) and the appropriate treatment.

Costs and barriers faced by households seeking malaria treatment in the Upper River Region, The Gambia

September 25, 2021 - 14:11 -- Open Access
Author(s): 
Henk Broekhuizen, Alexandra Fehr, Claudia Nieto-Sanchez, Joan Muela, Koen Peeters-Grietens, Tom Smekens, Momodou Kalleh, Esmé Rijndertse, Jane Achan and Umberto D’Alessandro
Reference: 
Malaria Journal 2021 20:368, 16 September 2021

Malaria transmission in The Gambia decreased substantially over the last 20 years thanks to the scale-up of control interventions. However, malaria prevalence is still relatively high in eastern Gambia and represents both a health and a financial burden for households. This study aims to quantify the out-of-pocket costs and productivity losses of seeking malaria treatment at household level.

Not Open Access | Oral-maxillofacial adverse events related to antimalarials

September 8, 2021 - 16:11 -- NOT Open Access
Author(s): 
Shuai Y, Wang J, Jiang H, Yu Y, Jin L
Reference: 
Oral Dis. 2021 Sep;27(6):1376-1382

Malaria is a worldwide parasitic disease, which affects millions of lives every year. Various medications are recommended by WHO for prevention and treatment of malaria. However, adverse events caused by antimalarials were frequently reported, some of which were severe and fatal.

NOT Open Access | Antimalarial chemoprophylaxis and treatment in the United States: Limited access and extreme price variability

August 11, 2021 - 15:00 -- NOT Open Access
Author(s): 
Frosch AE, Thielen BK, Alpern JD, Walz EJ, Volkman HR, Smith M, Wanduragala D, Holder W, Boumi AE, Stauffer WM
Reference: 
J Travel Med. 2021 Aug 3:taab117

To evaluate if cost and availability of antimalarials are barriers to malaria chemoprophylaxis and treatment, we surveyed retail pharmacies in Minneapolis/Saint Paul and New York City on the price and stocking of antimalarials.

NOT Open Access | Intranasal artesunate-loaded nanostructured lipid carriers: A convenient alternative to parenteral formulations for the treatment of severe and cerebral malaria

June 15, 2021 - 15:09 -- NOT Open Access
Author(s): 
Agbo CP, Ugwuanyi TC, Ugwuoke WI, McConville C, Attama AA, Ofokansi KC
Reference: 
J Control Release. 2021 Jun 10;334:224-236

Early treatment with parenteral antimalarials is key in preventing deaths and complications associated with severe and cerebral malaria. This can be challenging in 'hard-to-reach' areas in Africa where transit time to hospitals with facilities to administer drugs parenterally can be more than 6 h. Consequently, the World Health Organization has recommended the use of artesunate (ATS) suppositories for emergency treatment of patients, however, this treatment is only for children under 6 years. The intranasal route (INR) can provide a safe and effective alternative to parenteral and rectal routes for patients of all ages; thus, reducing delays to the initiation of treatment.

NOT Open Access | Platelet Membrane-Coated and VAR2CSA Malaria Protein-Functionalized Nanoparticles for Targeted Treatment of Primary and Metastatic Cancer

June 1, 2021 - 12:21 -- NOT Open Access
Author(s): 
Zhou M, Lai W, Li G, Wang F, Liu W, Liao J, Yang H, Liu Y, Zhang Q, Tang Q, Hu C, Huang J, Zhang R
Reference: 
ACS Appl Mater Interfaces. 2021 May 26

Metastasis is the main cause of death in cancer patients. The efficacy of pharmacological therapy for cancer is limited by the heterogeneous nature of cancer cells and the lack of knowledge of microenvironments in metastasis. Evidence has shown that activated platelets possess both tumor-homing and metastasis-targeting properties via intrinsic cell adhesion molecules on platelets, and malaria protein VAR2CSA is able to specifically bind to oncofetal chondroitin sulfate, which is overexpressed on cancer cells with both epithelial and mesenchymal phenotypes.

Malaria prevention and treatment in migrant agricultural workers in Dangur district, Benishangul-Gumuz, Ethiopia: social and behavioural aspects

May 19, 2021 - 15:32 -- Open Access
Author(s): 
Yehualashet Tadesse, Seth R. Irish, Matthew Murphy, et al.
Reference: 
Malaria Journal 2021 20:224, 19 May 2021

Sixty percent of the Ethiopia population is at risk of malaria, with the highest prevalence reported in Gambella (6%) and Benishangul-Gumuz (3%) regions. Within these regions are large agricultural developments with high numbers of seasonal migrant workers. The migrant workers are believed to be at increased risk for malaria infection due to their poor living conditions and outdoor activities, but there is little information on their specific behaviours and health risks. This study was conducted to address this gap.

A small window into the status of malaria in North Korea: estimation of imported malaria incidence of the visitors

November 25, 2020 - 12:13 -- Open Access
Author(s): 
Sung J, Cheong HK, Lim AY, Kim JH
Reference: 
Epidemiol Health. 2020 Nov 21:e2020068

This study aimed to hypothesize on the trend in malaria incidence in North Korea using malaria incidence among South Korean visitors to North Korea.

Spatial and spatio-temporal analysis of malaria cases in Zimbabwe

October 28, 2020 - 08:35 -- Open Access
Author(s): 
Gwitira I, Mukonoweshuro M, Mapako G, Shekede MD, Chirenda J, Mberikunashe J
Reference: 
Infect Dis Poverty. 2020 Oct 22;9(1):146

Although effective treatment for malaria is now available, approximately half of the global population remain at risk of the disease particularly in developing countries. To design effective malaria control strategies there is need to understand the pattern of malaria heterogeneity in an area. Therefore, the main objective of this study was to explore the spatial and spatio-temporal pattern of malaria cases in Zimbabwe based on malaria data aggregated at district level from 2011 to 2016.

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