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Health systems readiness and quality of inpatient malaria case-management in Kano State, Nigeria

November 4, 2020 - 09:55 -- Open Access
Abiodun A. Ojo, Kolawole Maxwell, Dejan Zurovac, et al.
Malaria Journal 2020 19:384, 30 October 2020

Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine to artesunate. Seven years after the policy change health systems readiness and quality of inpatient malaria case-management practices were evaluated in Kano State of Nigeria.

Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria

October 31, 2020 - 09:24 -- Open Access
Tola M, Ajibola O, Idowu ET, Omidiji O, Awolola ST, Amambua-Ngwa A.
BMC Res Notes. 2020 Oct 27;13(1):497

Nigeria bears 25% of global malaria burden despite concerted efforts towards its control and elimination. The emergence of drug resistance to first line drugs, artemisinin combination therapies (ACTs), indicates an urgent need for continuous molecular surveillance of drug resistance especially in high burden countries where drug interventions are heavily relied on. This study describes mutations in Plasmodium falciparum genes associated with drug resistance in malaria; Pfk13, Pfmdr1, PfATPase6 and Pfcrt in isolates obtained from 83 symptomatic malaria patients collected in August 2014, aged 1–61 years old from South-west Nigeria.

NOT Open Access | Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria. Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation

October 7, 2020 - 15:43 -- NOT Open Access
Bharti AR, McCutchan JA, Umlauf A, Okwuegbuna OK, Letendre S, Cherner M, Burdo T, Jumare J, Williams K, Blattner W, Royal W
J Acquir Immune Defic Syndr. 2020 Oct 1

HIV and malaria are associated with immunological perturbations and neurocognitive disorders even when asymptomatic. However, the effect of asymptomatic malaria (AM) in HIV-infected adults on neurocognitive impairment (NCI) is not well understood. This study investigated the biomarkers of systemic inflammation and neurocognition in dually-infected Nigerian adults.

NOT Open Access | Depletion of cholesterol could be associated with modulation of progesterone but not other sex hormone levels during Plasmodium falciparum infection in humans: a cross-sectional study from Zaria, Nigeria

September 23, 2020 - 08:46 -- NOT Open Access
Usman MA, Ibrahim MA, Salman AA, Sallau AB
Parasitol Res. 2020 Sep 20

In order for Plasmodium falciparum to grow and survive in its host, membrane biogenesis, fueled by host cholesterol, is essential for these processes. Consistent with this essential role, more insights into the cholesterol pathway would enhance the current understanding of the pathophysiology of malaria infection. To explore its broader potential, we conducted a cross-sectional study and assayed for the serum levels of cholesterol, vitamin D, progesterone, testosterone, estradiol and bile acid in both P. falciparum-infected patients and apparently healthy sex-matched participants.

NOT Open Access | Multilevel modelling of the risk of malaria among children aged under five years in Nigeria

September 22, 2020 - 10:31 -- NOT Open Access
Oguoma VM, Anyasodor AE, Adeleye AO, Eneanya OA, Mbanefo EC
Trans R Soc Trop Med Hyg. 2020 Sep 18:traa096

Malaria is still a major cause of morbidity and mortality among children aged <5 y (U5s). This study assessed individual, household and community risk factors for malaria in Nigerian U5s.

Community Voice Matters: Lessons from Field Studies of Malaria

September 15, 2020 - 15:06 -- Open Access
Aju-Ameh C
Am J Trop Med Hyg. 2020 Sep;103(3):945-946

I have always been curious about arthropods and the dis-eases they transmit to humans. Growing up in a malaria-endemic area (Benue, Nigeria) exposed my family members and me to the revulsions of malaria disease. Children were theworst hit.

Early warning climate indices for malaria and meningitis in tropical ecological zones

September 2, 2020 - 08:30 -- Open Access
Ayanlade A, Nwayor IJ, Sergi C, Ayanlade OS, Di Carlo P, Jeje OD, Jegede MO
Sci Rep. 2020 Aug 31;10(1):14303.

This study aims at assessing the impacts of climate indices on the spatiotemporal distribution of malaria and meningitis in Nigeria. The primary focus of the research is to develop an Early Warning System (EWS) for assessing climate variability implications on malaria and meningitis spread in the study area. Both climate and health data were used in the study to determine the relationship between climate variability and the occurrence of malaria and meningitis. The assessment was based on variations in different ecological zones in Nigeria.

Investigating the molecular basis of multiple insecticide resistance in a major malaria vector Anopheles funestus (sensu stricto) from Akaka-Remo, Ogun State, Nigeria

August 19, 2020 - 16:09 -- Open Access
Atoyebi SM, Tchigossou GM, Djouaka R, et al.
Parasit Vectors. 2020 Aug 18;13(1):423

Understanding the mechanisms used by Anopheles mosquitoes to survive insecticide exposure is key to manage existing insecticide resistance and develop more suitable insecticide-based malaria vector control interventions as well as other alternative integrated tools. To this regard, the molecular basis of permethrin, DDT and dieldrin resistance in Anopheles funestus (sensu stricto) at Akaka-Remo was investigated.

Rural–urban disparities and factors associated with delayed care-seeking and testing for malaria before medication use by mothers of under-five children, Igabi LGA, Kaduna Nigeria

August 19, 2020 - 09:30 -- Open Access
Obafemi J. Babalola, Olufemi Ajumobi and IkeOluwapo O. Ajayi
Malaria Journal 2020 19:294, 18 August 2020

Fever in under-five children (U5) is the commonest presenting complaint in general practice and mothers’ recognition is an entry point for fever treatment, including malaria. This study describes rural–urban disparity in fever prevalence in U5, mothers’ malaria knowledge, care-seeking, testing for malaria before anti-malarial medication and the associated factors.

NOT Open Access | Analysis of sulphadoxine-pyrimethamine resistance-associated mutations in Plasmodium falciparum isolates obtained from asymptomatic pregnant women in Ogun State, Southwest Nigeria

August 19, 2020 - 09:17 -- NOT Open Access
Fagbemi KA, Adebusuyi SA, Nderu D, Adedokun SA, Pallerla SR, Amoo AOJ, Thomas BN, Velavan TP, Ojurongbe O
Infect Genet Evol. 2020 Aug 14:104503

Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) is one of the main strategies for protecting pregnant women, fetus, and their new-born against adverse effects of P. falciparum infection. The development of the drug resistance linked to mutations in P. falciparum dihydrofolate reductase gene (pfdhfr) and P. falciparum dihydropteroate synthase gene (pfdhps), is currently threatening the IPTp-SP approach.


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