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Acceptability of peer learning and education approach on malaria prevention (PLEA-malaria) through primary schools communities in rural Ethiopia: peer educators’ perspectives

November 23, 2021 - 09:22 -- Open Access
Fira Abamecha, Alemayehu Deressa, Morankar Sudhakar, Lakew Abebe, Yohannes Kebede, Dejene Tilahun, Firanbon Teshome and Zewdie Birhanu
Malaria Journal 2021 20:437, 15 November 2021

Evidence on peer educators’ experiences of implementing the school-based educational interventions on malaria prevention would be used as inputs for malaria eliminating efforts. This study explored the acceptability of the school-based peer-learning and education approach on malaria prevention (PLEA-malaria) among peer educators in Ethiopia.

Practices of anti-malaria pharmaceuticals inventory control system and associated challenges in public health facilities of Oromiya special zone, Amhara region, Ethiopia

November 10, 2021 - 20:54 -- Open Access
Mengesha HY, Gebrehiwot GM, Workneh BD, Kahissay MH
BMC Public Health. 2021 Nov 6;21(1):2026

Anti-malaria pharmaceuticals inventory control system helps to maintain an appropriate stock level using logistics management information system records and reports. Antimalaria pharmaceuticals are highly influenced by seasonality and demand variation. Thus, to compensate the seasonality, resupply quantities should be adjusted by multiplying the historical consumption with the Look-ahead seasonality indexes (LSI) to minimize stock-outs during the peak transmission season and overstocks (possible expiries) during off-peak seasons The purpose of this study was to assess anti-malaria pharmaceuticals inventory control practice and associated challenges in public health facilities of the Oromiya special zone, Amhara region, Ethiopia.

Baseline malaria prevalence at the targeted pre-elimination districts in Ethiopia

November 4, 2021 - 12:58 -- Open Access
Nega D, Abera A, Abate E, et al.
BMC Public Health. 2021 Nov 3;21(1):1996

Encouraged by the previous success in malaria control and prevention strategies, the Ethiopian ministry of health launched malaria elimination with a stepwise approach by primarily targeting the low-transmission Districts and their adjacent areas/zones in order to shrink the country’s malaria map progressively. Hence, this community survey was conducted to establish baseline malaria information at the preliminary phase of elimination at targeted settings.

Comorbidity of Geo-Helminthes among Malaria Outpatients of the Health Facilities in Ethiopia: Systematic Review and Meta-Analysis

October 30, 2021 - 12:56 -- Open Access
Boltena MT, El-Khatib Z, Sahlemichael Kebede A, Asamoah BO, Tadesse Boltena A, Yeshambaw M, Biru M
Int J Environ Res Public Health. 2021 Jan 20;18(3):862

Coinfection of malaria and intestinal helminths affects one third of the global population, largely among communities with severe poverty. The spread of these parasitic infections overlays in several epidemiological locations and the host shows different outcomes. This systematic review and meta-analysis determine the pooled prevalence of malaria and intestinal helminthiases coinfections among malaria suspected patients in Ethiopia.

Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia: its impact on the performance of malaria rapid diagnostic tests

October 23, 2021 - 18:09 -- Open Access
Gezahegn Solomon Alemayehu, Alebachew Messele, Kayla Blackburn, Karen Lopez, Eugenia Lo, Daniel Janies and Lemu Golassa
Malaria Journal 2021 20:394, 9 October 2021

Rapid diagnostic tests (RDT) are commonly used for the diagnosis of malaria caused by Plasmodium falciparum. However, false negative results of RDT caused by genetic variation of P. falciparum histidine-rich protein 2 and 3 genes (pfhrp2/3) threaten existing malaria case management and control efforts. The main objective of this study was to investigate the genetic variations of the pfhrp2/3 genes.

The effect of irrigation on malaria vector bionomics and transmission intensity in western Ethiopia

October 16, 2021 - 13:07 -- Open Access
Haileselassie W, Zemene E, Lee MC, Zhong D, Zhou G, Taye B, Dagne A, Deressa W, Kazura JW, Yan G, Yewhalaw D
Parasit Vectors. 2021 Oct 7;14(1):516

Irrigation schemes may result in subsequent changes in malaria disease dynamics. Understanding the mechanisms and effects of irrigation on malaria vector bionomics and transmission intensity is essential to develop new or alternative surveillance and control strategies to reduce or control malaria risk. This study was designed to assess the effect of rice irrigation on malaria vector bionomics and transmission intensity in the Gambella Region, Ethiopia.

Prevalence and associated factors of malaria in children under the age of five years in Wogera district, northwest Ethiopia: A cross-sectional study

October 16, 2021 - 13:00 -- Open Access
Tsegaye AT, Ayele A, Birhanu S
PLoS One. 2021 Oct 11;16(10):e0257944

Malaria is a major public health problem in sub-Saharan Africa, and children are especially vulnerable. In 2019, an estimated 409,000 people died of malaria, most (274,000) were young children and 94% of the cases and deaths were in Africa. Prior studies in Ethiopia focused on the adult population and high transmission areas. Hence, this study aimed to determine the prevalence and associated factors of malaria in children under five years in low transmission areas.

Spatial distribution of Plasmodium falciparum and P. vivax in northern Ethiopia by microscopy, rapid diagnostic test, laboratory antibody and antigen data

October 13, 2021 - 12:34 -- Open Access
Leonard CM, Assefa A, Sime H, Mohammed H, Kebede A, Solomon H, Drakeley C, Murphy M, Hwang J, Rogier E
J Infect Dis. 2021 Oct 10:jiab489

Determining malaria transmission within regions of low, heterogenous prevalence is difficult. A variety of malaria tests exist and range from identification of diagnostic infection to testing for prior exposure. This study describes concordance of multiple malaria tests using data from a 2015 household survey conducted in Ethiopia.

Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia

October 9, 2021 - 09:58 -- Open Access
Temesgen File, Tsegaye Chekol, Gezahegn Solomon, Hunduma Dinka and Lemu Golassa
Malaria Journal 2021 20:385, 27 September 2021

One of the major challenges in developing an effective vaccine against asexual stages of Plasmodium falciparum is genetic polymorphism within parasite population. Understanding the genetic polymorphism like block 2 region of merozoite surface protein-1 (msp-1) gene of P. falciparum enlighten mechanisms underlining disease pathology, identification of the parasite clone profile from the isolates, transmission intensity and potential deficiencies of the ongoing malaria control and elimination efforts in the locality. Detailed understanding of local genetic polymorphism is an input to pave the way for better management, control and elimination of malaria. The aim of this study was to detect the most frequent allelic variant of the msp-1 gene of P. falciparum clinical isolates from selected health facilities in Adama town and its surroundings, Oromia, Ethiopia.

Performance of rapid diagnostic tests, microscopy, loop-mediated isothermal amplification (LAMP) and PCR for malaria diagnosis in Ethiopia: a systematic review and meta-analysis

October 9, 2021 - 09:56 -- Open Access
Daniel Getacher Feleke, Yonas Alemu and Nebiyou Yemanebirhane
Malaria Journal 2021 20:384, 27 September 2021

Rapid accurate diagnosis followed by effective treatment is very important for malaria control. Light microscopy remains the “golden standard” method for malaria diagnosis. Diagnostic test method must have sufficient level of accuracy for detecting malaria parasites. Therefore, this study aimed to investigate the diagnostic accuracy of rapid diagnostic tests (RDTs), microscopy, loop-mediated isothermal amplification (LAMP) and/or polymerase chain reaction (PCR) for the malaria diagnosis in Ethiopia.


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