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insecticide resistance

A survey of insecticide resistance-conferring mutations in multiple targets in Anopheles sinensis populations across Sichuan, China

March 23, 2021 - 14:50 -- Open Access
Qian W, Liu N, Yang Y, Liu J, He J, Chen Z, Li M, Qiu X
Parasit Vectors. 2021 Mar 20;14(1):169

Sichuan province is located in the southwest of China, and was previously a malaria-endemic region. Although no indigenous malaria case has been reported since 2011, the number of imported cases is on the rise. Insecticide-based vector control has played a central role in the prevention of malaria epidemics. However, the efficacy of this strategy is gravely challenged by the development of insecticide resistance. Regular monitoring of insecticide resistance is essential to inform evidence-based vector control. Unfortunately, almost no information is currently available on the status of insecticide resistance and associated mechanisms in Anopheles sinensis, the dominant malaria vector in Sichuan. In this study, efforts were invested in detecting the presence and frequency of insecticide resistance-associated mutations in three genes that encode target proteins of several classes of commonly used insecticides.

NOT Open Access | Potentiation Effects of Ficus sycomorus Active Fraction Against Permethrin-Resistant Field-Population of Anopheles coluzzii (Diptera: Culicidae)

March 9, 2021 - 15:39 -- NOT Open Access
Anosike CA, Babandi A, Ezeanyika LUS
Neotrop Entomol (2021)

Insecticide resistance in mosquitoes is increasing amidst growing cases of global malaria, leading to high fatality in mostly Africa. To overcome the resistance as well as environmental effects of the synthetic insecticides, preliminary insecticidal and botanical potentiating effects of sub-lethal concentration (LC25) Ficus sycomorus active fraction (AFFS) and its synergistic potential with standard insecticide permethrin were evaluated against malarial vector Anopheles coluzzii (Coetzee & Wilkerson) populations. The glutathione-S-transferase (GST) inhibitory activity of the AFFS was also investigated compared to standard GST inhibitor, diethyl meleate (DEM).

Insecticide resistance status of indoor and outdoor resting malaria vectors in a highland and lowland site in Western Kenya

March 2, 2021 - 15:19 -- Open Access
Owuor KO, Machani MG, Mukabana WR, Munga SO, Yan G, Ochomo E, Afrane YA
PLoS One. 2021 Mar 1;16(3):e0240771

Long Lasting Insecticidal Nets (LLINs) and indoor residual spraying (IRS) represent powerful tools for controlling malaria vectors in sub-Saharan Africa. The success of these interventions relies on their capability to inhibit indoor feeding and resting of malaria mosquitoes. This study sought to understand the interaction of insecticide resistance with indoor and outdoor resting behavioral responses of malaria vectors from Western Kenya.

Malaria vectors diversity, insecticide resistance and transmission during the rainy season in peri-urban villages of south-western Burkina Faso

January 27, 2021 - 15:52 -- Open Access
Dieudonné Diloma Soma, Serge Bèwadéyir Poda, Roch Kounbobr Dabiré, et al.
Malaria Journal 2021 20:63, 25 January 2021

This study reports an updated description on malaria vector diversity, behaviour, insecticide resistance and malaria transmission in the Diébougou and Dano peri-urban areas, Burkina Faso.

Monitoring insecticide resistance in malaria vectors in Shandong Province: approaching malaria elimination

December 3, 2020 - 13:27 -- Open Access
Cheng P, Liu L, Lv Y, Wang H, Gong M, Liu H
J Vector Ecol. 2020 Dec;45(2):380-383

Since the malaria elimination program was launched in China in 2010, the number of local infections has declined from 4,262 in 2010 to none in 2017, indicating remarkable achievements for prevention and treatment (Zhang et al. 2018). Shandong Province is a malaria‐endemic area, and vivax malaria is prevalent throughout the province.

Identification of main malaria vectors and their insecticide resistance profile in internally displaced and indigenous communities in Eastern Democratic Republic of the Congo (DRC)

November 24, 2020 - 14:56 -- Open Access
Jeanine A. C. M. Loonen, Dominic B. Dery, Bertin Z. Musaka, Janvier B. Bandibabone, Teun Bousema, Marit van Lenthe, Biserka Pop-Stefanija, Jean-François Fesselet and Constantianus J. M. Koenraadt
Malaria Journal 2020 19:425, 23 November 2020

Malaria remains a major public health concern in the Democratic Republic of the Congo (DRC) and its control is affected by recurrent conflicts. Médecins Sans Frontières (MSF) initiated several studies to better understand the unprecedented incidence of malaria to effectively target and implement interventions in emergency settings. The current study evaluated the main vector species involved in malaria transmission and their resistance to insecticides, with the aim to propose the most effective tools and strategies for control of local malaria vectors.

Spatial Anopheles arabiensis (Diptera: Culicidae) insecticide resistance patterns across malaria-endemic regions of Botswana

November 24, 2020 - 13:44 -- Open Access
Mmabaledi Buxton, Ryan J. Wasserman and Casper Nyamukondiwa
Malaria Journal 2020 19:415, 19 November 2020

Since the advent of the Green Revolution, pesticides have played an important role in the global management of invertebrate pests including vector mosquitoes. Despite optimal efficacy, insects often display insensitivity to synthetic insecticides owing to prolonged exposure that may select for resistance development. Such insecticide insensitivity may regress national and regional coordination in mosquito vector management and indeed malaria control. In Botswana, prolonged use of synthetic insecticides against malaria vectors have been practiced without monitoring of targeted mosquito species susceptibility status.

Multiple insecticide resistance target sites in adult field strains of An. gambiae (s.l.) from southeastern Senegal

November 14, 2020 - 16:15 -- Open Access
Diouf EH, Niang EHA, Samb B, Diagne CT, Diouf M, Konaté A, Dia I, Faye O, Konaté L
Parasit Vectors. 2020 Nov 11;13(1):567

High coverage of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are the cornerstones of vector control strategy in Senegal where insecticide resistance by the target vectors species is a great of concern. This study explores insecticide susceptibility profile and target-site mutations mechanisms within the Anopheles gambiae complex in southeastern Senegal.

Comparative assessment of insecticide resistance phenotypes in two major malaria vectors, Anopheles funestus and Anopheles arabiensis in south-eastern Tanzania

November 14, 2020 - 16:00 -- Open Access
Polius G. Pinda, Claudia Eichenberger, Halfan S. Ngowo, Dickson S. Msaky, Said Abbasi, Japhet Kihonda, Hamis Bwanaly and Fredros O. Okumu
Malaria Journal 2020 19:408, 11 November 2020

Long-lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS) have greatly reduced malaria transmission in sub-Saharan Africa, but are threatened by insecticide resistance. In south-eastern Tanzania, pyrethroid-resistant Anopheles funestus are now implicated in > 80% of malaria infections, even in villages where the species occurs at lower densities than the other vector, Anopheles arabiensis. This study compared the insecticide resistance phenotypes between the two malaria vectors in an area where pyrethroid-LLINs are widely used.

Reduced long-lasting insecticidal net efficacy and pyrethroid insecticide resistance are associated with over-expression of CYP6P4, CYP6P3 and CYP6Z1 in populations of Anopheles coluzzii from South-East Côte d'Ivoire

November 12, 2020 - 15:38 -- Open Access
Meiwald A, Clark E, Kristan M, Edi C, Jeffries CL, Pelloquin B, Irish SR, Walker T, Messenger LA
J Infect Dis. 2020 Nov 11:jiaa699

Resistance to major public health insecticides in Côte d’Ivoire has intensified and now threatens the long-term effectiveness of malaria vector control interventions.


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