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insecticide resistance

An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons

June 8, 2020 - 14:50 -- Open Access
Author(s): 
Weedall GD, Riveron JM, Hearn J, Irving H, Kamdem C, Fouet C, White BJ, Wondji CS
Reference: 
PLoS Genet 16(6): e1008822

Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control. Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to improve control strategies and preventing malaria resurgence. A genome-wide survey of Anopheles funestus genetic diversity Africa-wide revealed evidences of a major division between southern Africa and elsewhere, associated with different population histories.

'What I cannot create, I do not understand': functionally validated synergism of metabolic and target site insecticide resistance

May 27, 2020 - 10:39 -- Open Access
Author(s): 
Samantsidis GR, Panteleri R, Denecke S, Kounadi S, Christou I, Nauen R, Douris V, Vontas J
Reference: 
Proc Biol Sci. 2020 May 27;287(1927):20200838

The putative synergistic action of target-site mutations and enhanced detoxification in pyrethroid resistance in insects has been hypothesized as a major evolutionary mechanism responsible for dramatic consequences in malaria incidence and crop production. Combining genetic transformation and CRISPR/Cas9 genome modification, we generated transgenic Drosophila lines expressing pyrethroid metabolizing P450 enzymes in a genetic background along with engineered mutations in the voltage-gated sodium channel (para) known to confer target-site resistance.

Insecticide resistance in Anopheles stephensi in Somali Region, eastern Ethiopia

May 12, 2020 - 16:42 -- Open Access
Author(s): 
Solomon Yared, Araya Gebressielasie, Lambodhar Damodaran, Victoria Bonnell, Karen Lopez, Daniel Janies and Tamar E. Carter
Reference: 
Malaria Journal 2020 19:180, 12 May 2020

The movement of malaria vectors into new areas is a growing concern in the efforts to control malaria. The recent report of Anopheles stephensi in eastern Ethiopia has raised the necessity to understand the insecticide resistance status of the vector in the region to better inform vector-based interventions. The aim of this study was to evaluate insecticide resistance in An. stephensi in eastern Ethiopia using two approaches: (1) World Health Organization (WHO) bioassay tests in An. stephensi; and (2) genetic analysis of insecticide resistance genes in An. stephensi in eastern Ethiopia.

Exploring the Mechanisms of Multiple Insecticide Resistance in a Highly Plasmodium-Infected Malaria Vector Anopheles funestus Sensu Stricto from Sahel of Northern Nigeria

April 27, 2020 - 13:20 -- Open Access
Author(s): 
Ibrahim SS, Mukhtar MM, Irving H, Riveron JM, Fadel AN, Tchapga W, Hearn J, Muhammad A, Sarkinfada F, Wondji CS
Reference: 
Genes (Basel). 2020 Apr 22;11(4). pii: E454

The Nigerian Government is scaling up the distribution of insecticide-treated bed nets for malaria control, but the lack of surveillance data, especially in the Sudan/Sahel region of the country, may hinder targeting priority populations. Here, the vectorial role and insecticide resistance profile of a population of a major malaria vector Anopheles funestus sensu stricto from Sahel of Nigeria was characterised.

NOT Open Access | Control of malaria vectors and management of insecticide resistance through universal coverage with next-generation insecticide-treated nets

April 20, 2020 - 09:35 -- NOT Open Access
Author(s): 
Killeen GF
Reference: 
Lancet. 2020 Apr 15. pii: S0140-6736(20)30745-5

No abstract available

A preliminary analysis on the effect of copper on Anopheles coluzzii insecticide resistance in vegetable farms in Benin

April 15, 2020 - 14:23 -- Open Access
Author(s): 
Talom AD, Essoung MA, Gbankoto A, Tchigossou G, Akoton R, Sahabi BBA, Atoyebi SM, Fotso Kuate A, Verspoor RL, Tamò M, Tchuinkam T, Lehman GL, Lines J, Wondji CS, Djouaka R
Reference: 
Sci Rep. 2020 Apr 14;10(1):6392

The use of agrochemicals in vegetable production could influence the selection for insecticide resistance in malaria vectors. Unfortunately, there is a dearth of information on the potential contribution of agrochemicals to insecticide resistance in Anopheles mosquitoes breeding on vegetable farms in southern Benin.

The role of windows of selection and windows of dominance in the evolution of insecticide resistance in human disease vectors

April 6, 2020 - 08:15 -- Open Access
Author(s): 
South A, Lees R, Garrod G, Carson J, Malone D, Hastings I
Reference: 
Evol Appl. 2019 Dec 10;13(4):738-751

Persistent insecticides sprayed onto house walls, and incorporated into insecticide‐treated bednets, provide long‐acting, cost‐effective control of vector‐borne diseases such as malaria and leishmaniasis. The high concentrations that occur immediately postdeployment may kill both resistant and susceptible insects.

Anopheline bionomics, insecticide resistance and transnational dispersion in the context of controlling a possible recurrence of malaria transmission in Jaffna city in northern Sri Lanka

April 3, 2020 - 09:35 -- Open Access
Author(s): 
Surendran SN, Jayadas TTP, Tharsan A, Thiruchenthooran V, Santhirasegaram S, Sivabalakrishnan K, Raveendran S, Ramasamy R
Reference: 
Parasit Vectors. 2020 Mar 30;13(1):156

Malaria was eliminated from Sri Lanka in 2013. However, the influx of infected travelers and the presence of potent anopheline vectors can re-initiate transmission in Jaffna city, which is separated by a narrow strait from the malaria-endemic Indian state of Tamil Nadu.

Potential Roles of Environmental and Socio-Economic Factors in the Distribution of Insecticide Resistance in Anopheles gambiae sensu lato (Culicidae: Diptera) Across Togo, West Africa

March 3, 2020 - 15:06 -- Open Access
Author(s): 
Ahadji-Dabla KM, Romero-Alvarez D, Ketoh GK, et al.
Reference: 
Journal of Medical Entomology, tjaa023

Vector control strategies recommended by the World Health Organization are threatened by resistance of Anopheles mosquitoes to insecticides. Information on the distribution of resistant genotypes of malaria vectors is increasingly needed to address the problem. Ten years of published and unpublished data on malaria vector susceptibility/resistance and resistance genes have been collected across Togo.

A survey of Anopheles species composition and insecticide resistance on the island of Bubaque, Bijagos Archipelago, Guinea-Bissau

January 20, 2020 - 15:52 -- Open Access
Author(s): 
Thomas Ant, Erin Foley, David Mabey, et al.
Reference: 
Malaria Journal 2020 19:27, 15 January 2020

Bubaque is the most populous island of the Bijagos archipelago, a group of malaria-endemic islands situated off the coast of Guinea-Bissau, West Africa. Malaria vector control on Bubaque relies almost exclusively on the use of long-lasting insecticidal nets (LLINs). However, there is little information on local vector bionomics and insecticide resistance.

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