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plasmodium sporozoite

Fluorescent tagging of Plasmodium circumsporozoite protein allows imaging of sporozoite formation but blocks egress from oocysts

February 23, 2021 - 13:06 -- Open Access
Singer M, Frischknecht F
Cell Microbiol. 2021 Feb 18:e13321

The circumsporozoite protein, CSP is the major surface protein of Plasmodium sporozoites, the form of malaria parasites transmitted by mosquitoes. CSP is involved in sporozoite formation within and egress from oocysts, entry into mosquito salivary glands and mammalian liver as well as migration in the skin. Yet, how CSP facilitates sporozoite formation, oocyst egress and hepatocyte specific invasion is still not fully understood.

NOT Open Access | Secretory Organelle Function in the Plasmodium Sporozoite

February 16, 2021 - 15:38 -- NOT Open Access
Arredondo SA, Schepis A, Reynolds L, Kappe SHI
Trends Parasitol. 2021 Feb 13:S1471-4922(21)00011-8

Plasmodium sporozoites exhibit a complex infection biology in the mosquito and mammalian hosts. The sporozoite apical secretory organelles, the micronemes and rhoptries, store protein mediators of parasite/host/vector interactions and must secrete them in a temporally and spatially well orchestrated manner.

Malaria vectors diversity, insecticide resistance and transmission during the rainy season in peri-urban villages of south-western Burkina Faso

January 27, 2021 - 15:52 -- Open Access
Dieudonné Diloma Soma, Serge Bèwadéyir Poda, Roch Kounbobr Dabiré, et al.
Malaria Journal 2021 20:63, 25 January 2021

This study reports an updated description on malaria vector diversity, behaviour, insecticide resistance and malaria transmission in the Diébougou and Dano peri-urban areas, Burkina Faso.

Regulation of Plasmodium sporozoite motility by formulation components

May 7, 2019 - 13:32 -- Open Access
Clarize M. de Korne, Luuk T. Lageschaar, Meta Roestenberg, et al.
Malaria Journal 2019 18:155, 2 May 2019

The protective efficacy of the most promising malaria whole-parasite based vaccine candidates critically depends on the parasite’s potential to migrate in the human host. Key components of the parasite motility machinery (e.g. adhesive proteins, actin/myosin-based motor, geometrical properties) have been identified, however the regulation of this machinery is an unknown process.

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

May 11, 2016 - 16:23 -- Open Access
Kristian E. Swearingen, Scott E. Lindner, Photini Sinnis, et al.
PLoS Pathog 12(4): e1005606

Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly motile invasive cell that targets hepatocytes in the liver for infection.

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