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Not Open Access | Identification of an Atg8-Atg3 Protein–Protein Interaction Inhibitor from the Medicines for Malaria Venture Malaria Box Active in Blood and Liver Stage Plasmodium falciparum Parasites

May 20, 2014 - 17:01 -- NOT Open Access
Adelaide U.P. Hain, David Bartee, Natalie G. Sanders, Alexia S. Miller, David J. Sullivan, Jelena Levitskaya, Caren Freel Meyers and Jürgen Bosch
J. Med. Chem., 2014

Here, we describe the identification of inhibitors from the Malaria Medicine Venture Malaria Box against the interaction of PfAtg8 with its E2-conjugating enzyme, PfAtg3, by surface plasmon resonance.

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CLOSED: Workshop: Second Annual International Workshop on Malaria and Related Haemosporidian Parasites of Wildlife

March 8, 2012 - 18:52 -- MalariaWorld Events

Date: Monday August 6th – Thursday August 9h, 2012


Location: National Conservation Training Center, Shepherdstown, West Virginia, USA


Sponsored by the NSF Research Coordination Network for Haemosporida of Terrestrial Vertebrates1

Open Access | Automated and unsupervised detection of malarial parasites in microscopic images

December 16, 2011 - 13:29 -- Patrick Sampao
Purwar Y, Shah SL, Clarke G, Almugairi A, Muehlenbachs A
Malaria Journal 2011, 10:364 (13 December 2011)

MalariaWorldThe focus of this study is to develop a robust, unsupervised and sensitive malaria screening technique with low material cost and one that has an advantage over other techniques in that it minimizes human reliance and is, therefore, more consistent in applying diagnostic criteria.

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Open Access | Phylogenomic analyses of malaria parasites and evolution of their exported proteins

June 16, 2011 - 08:33 -- Patrick Sampao
Christian Pick, Ingo Ebersberger, Tobias Spielmann , Iris Bruchhaus and Thorsten Burmester
BMC Evolutionary Biology 2011, 11:167

Our phylogenomic analyses strongly support the hypotheses that the Laverania have been founded by a single Plasmodium species switching from birds to African great apes or vice versa.

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Short Reports: Tales from the bench: laboratory diagnosis of malaria

June 7, 2011 - 14:06 -- Patrick Sampao
Hilary Edwards MSc MA
Trop Doct 2011;41:106-107

This is a practical laboratory overview of current detection methods for malaria parasites, suitable for use in developing countries.

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Entomological Study on Transmission of Avian Malaria Parasites in a Zoological Garden in Japan: Bloodmeal Identification and Detection of Avian Malaria Parasite DNA from Blood-Fed Mosquitoes

May 10, 2011 - 14:16 -- Patrick Sampao
Hiroko Ejiri, Yukita Sato, Kyeong-Soon Kim, Tatsuko Hara, Yoshio Tsuda, Takayuki Imura, Koichi Murata, and Masayoshi Yukawa
Journal of Medical Entomology 48(3):600-607. 2011

We investigated the prevalence and transmission of avian malaria parasite and determined the bloodmeal hosts of mosquitoes collected in a zoological garden in Tokyo, Japan, by using the polymerase chain reaction.


Opinion: Malaria and trypanosome transmission: different parasites, same rules?

April 29, 2011 - 08:54 -- Patrick Sampao
Laura C. Pollitt, Paula MacGregor, Keith Matthews, Sarah E. Reece
Trends in Parasitology, Volume 27, Issue 5, May 2011, Pages 197-203

An evolutionary approach has the power to explain why patterns of investment vary between strains and during infections, giving important insights into parasite biology.

Open Access | Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

April 1, 2011 - 12:41 -- Patrick Sampao
Brendan S Crabb, Tania F de Koning-Ward and Paul R Gilson
BMC Biology 2011, 9:21

This advance holds promise for identifying and validating new targets for intervention against malaria.

Open Access | Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites

March 22, 2011 - 13:10 -- Patrick Sampao
Jannik Fonager, Blandine MD Franke-Fayard , John H. Adams, Jai Ramesar, Onny Klop, Shahid M. Khan, Chris J. Janse and Andrew P. Waters
BMC Genomics 2011, 12:155

This study reports the development and application of the piggyBac transposition system for the rodent malaria parasite P. berghei and the evaluation of its potential as a tool in forward genetic studies. P. berghei is the most frequently used malaria parasite model in gene function analysis since phenotype screens throughout the complete Plasmodium life cycle are possible both in vitro and in vivo.

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