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Not Open Access | Analysis of immunogenicity of different protein groups from malaria parasite Plasmodium falciparum

November 12, 2012 - 15:14 -- NOT Open Access
KatarzynaKrzyczmonik, MichałŚwitnicki, SzymonKaczanowski
Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1911-1916

We confirmed the expectations that proteins containing IEDB epitopes are subject to stronger diversifying selection which is evidenced by higher pN/pS ratio. A stage characterized by the highest average pN/pS ratio is that of the sporozoite.

Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

October 23, 2012 - 14:56 -- Patrick Sampao
Bohórquez EB, Chua M, Meshnick SR
Malaria Journal 2012, 11:350 (22 October 2012)

MalariaWorldFluorescence microscopy was used to evaluate the subcellular localization of quinine in parasites containing different pfmdr1 copy numbers to determine if copy number of the gene affects drug localization.

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Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

October 10, 2012 - 16:16 -- Patrick Sampao
Shaun B Reeksting, Ingrid B. Müller, Pieter B Burger, Emmanuel S Burgos, Laurent Salmon, Abraham Izak Louw, Lyn-Marie Birkholtz and Carsten Wrenger
Biochem. J. (2012)

MalariaWorldWe demonstrate that d-erythrose 4-phosphate (E4P) inhibits PfPdx1 in a dose dependent manner. We propose that the acyclic phospho-sugar E4P, with a C1 aldehyde group similar to acyclic R5P, could interfere with R5P imine bond formations in the PfPdx1 reaction mechanism.

Not Open Access | Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei

September 4, 2012 - 14:45 -- Patrick Sampao
Akina Hino, Makoto Hirai, Takeshi Q. Tanaka, Yoh-ichi Watanabe, Hiroyuki Matsuoka and Kiyoshi Kita
J Biochem (2012) 152 (3): 259-268.

MalariaWorldThese results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production.

Not Open Access | Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite

August 22, 2012 - 14:58 -- Patrick Sampao
Maya Kono, Susann Herrmann, Tim W. Gilberger, et al.
Mol Biol Evol (2012) 29 (9): 2113-2132

MalariaWorldIn this article, we present a comprehensive evolutionary analysis of IMC components, which exemplifies the adaptive nature of the IMCs' protein composition.

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Not Open Access | Sickle Cell MicroRNAs Inhibit the Malaria Parasite

August 20, 2012 - 10:58 -- Patrick Sampao
Manoj T. Duraisingh, Harvey F. Lodish
Cell Host & Microbe, Volume 12, Issue 2, 16 August 2012, Pages 127-128

MalariaWorldIn this issue of Cell Host & Microbe, demonstrate a surprising mechanism for this innate immunity.

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Not Open Access | The role of cGMP signalling in regulating life cycle progression of Plasmodium

July 13, 2012 - 08:38 -- Patrick Sampao
Christine S. Hopp, Paul W. Bowyer, David A. Baker
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 831-837

MalariaWorldThis article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development.

Not Open Access | Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite

July 13, 2012 - 08:15 -- Patrick Sampao
Anthony A. Holder, Mohd A. Mohd Ridzuan, Judith L. Green
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 825-830

MalariaWorldApicomplexan parasites also contain CDPK families and this review is focused on CDPK1 in Plasmodium spp.

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NOT Open Access | Review: Development of humanized mouse models to study human malaria parasite infection

May 11, 2012 - 12:33 -- Patrick Sampao
Ashley M Vaughan, Stefan HI Kappe, Alexander Ploss & Sebastian A Mikolajczak
Future Microbiology, May 2012, Vol. 7, No. 5, Pages 657-665

MalariaWorldHere, we review the current state of research in this field and provide an outlook of the development of humanized small animal models to study P. falciparum infection that will accelerate fundamental research into human parasite biology and could accelerate drug and vaccine design in the future.

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Open Access | Evolution of the Multi-Domain Structures of Virulence Genes in the Human Malaria Parasite, Plasmodium falciparum

April 13, 2012 - 13:37 -- Patrick Sampao
Caroline O. Buckee, Mario Recker
PLoS Comput Biol 8(4): e1002451

MalariaWorldOur results demonstrate how simple evolutionary mechanisms can explain var gene structuring on multiple levels and have important implications for understanding the multifaceted epidemiology of P. falciparum malaria.


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