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natural immunization

Protective immunity against malaria by ‘natural immunization’: a question of dose, parasite diversity, or both?

August 31, 2011 - 07:18 -- Kabogo Ndegwa
Steffen Borrmann, Kai Matuschewski
Current Opinion in Immunology, Volume 23, Issue 4, August 2011, Pages 500-508

Plasmodium undergoes an obligate liver phase before the onset of malaria, which is caused exclusively by cyclic propagation of the parasite inside erythrocytes.

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Natural immunization against malaria: causal prophylaxis with antibiotics

July 19, 2010 - 12:23 -- Kabogo Ndegwa
J Friesen, O Silvie, ED Putrianti, JC Hafalla, K Matuschewski, S Borrmann
Sci Transl Med 14 July 2010, Vol. 2, Issue 40, p. 40ra49

Malaria remains the most prevalent vector-borne infectious disease and has the highest rates of fatality. Current antimalarial drug strategies cure malaria or prevent infections but lack a sustained public health impact because they fail to expedite the acquisition of protective immunity.

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