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sub-Saharan Africa

Proximity of Residence to Irrigation Determines Malaria Risk and Anopheles Abundance at an Irrigated Agroecosystem in Malawi

October 23, 2021 - 12:44 -- Open Access
Mangani C, Frake AN, Chipula G, Mkwaila W, Kakota T, Mambo I, Chingonda J, Mathanga D, Mzilahowa T, Zulu L, Walker E
Am J Trop Med Hyg. 2021 Oct 18:tpmd210390

As countries of sub-Saharan Africa expand irrigation to improve food security and foster economic growth, it is important to quantify the malaria risk associated with this process. Irrigated ecosystems can be associated with increased malaria risk, but this relationship is not fully understood. We studied this relationship at the Bwanje Valley Irrigation Scheme (800 hectares) in Malawi.

Malaria vaccine approval: a step change for global health

October 23, 2021 - 12:22 -- Open Access
The Lancet
Lancet. 2021 Oct 16;398(10309):1381

On Oct 6, WHO announced that it will be recommending widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine for children in sub-Saharan Africa and in other regions with moderate-to-high Plasmodium falciparum transmission.

Relative Burdens of the COVID-19, Malaria, Tuberculosis, and HIV/AIDS Epidemics in Sub-Saharan Africa

October 16, 2021 - 12:16 -- Open Access
Bell D, Schultz Hansen K
Am J Trop Med Hyg. 2021 Oct 11:tpmd210899

COVID-19 has had considerable global impact; however, in sub-Saharan Africa, it is one of several infectious disease priorities. Prioritization is normally guided by disease burden, but the highly age-dependent nature of COVID-19 and that of other infectious diseases make comparisons challenging unless considered through metrics that incorporate life-years lost and time lived with adverse health.

Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya

October 13, 2021 - 12:45 -- Open Access
Osborne A, Manko E, Takeda M, Kaneko A, Kagaya W, Chan C, Ngara M, Kongere J, Kita K, Campino S, Kaneko O, Gitaka J, Clark TG
Sci Rep. 2021 Oct 6;11(1):19809

Characterising the genomic variation and population dynamics of Plasmodium falciparum parasites in high transmission regions of Sub-Saharan Africa is crucial to the long-term efficacy of regional malaria elimination campaigns and eradication. Whole-genome sequencing (WGS) technologies can contribute towards understanding the epidemiology and structural variation landscape of P. falciparum populations, including those within the Lake Victoria basin, a region of intense transmission. Here we provide a baseline assessment of the genomic diversity of P. falciparum isolates in the Lake region of Kenya, which has sparse genetic data.

Not Open Access | Learnings from two independent malaria elimination demonstration projects in India

October 5, 2021 - 10:53 -- NOT Open Access
Rajvanshi H, Mishra K, Lal AA, et al.
Trans R Soc Trop Med Hyg. 2021 Sep 25:trab148

India and sub-Saharan Africa contributes about 85% of the global malaria burden, and India is committed to eliminating malaria by 2030.

Care-seeking delay of imported malaria to China: Implications for improving post-travel healthcare for migrant workers

October 2, 2021 - 13:08 -- Open Access
Lu G, Cao Y, Chen Q, Zhu G, Müller O, Cao J
J Travel Med. 2021 Sep 28:taab156

Imported malaria cases continue to pose major challenges in China as well as in other countries having achieved elimination. Our study aims to identify the factors influencing the timing of care-seeking after symptom onset among migrant workers with imported malaria, in order to develop innovative interventions to improve access and provision of post-travel healthcare for returning migrants.

NOT Open Access | Suppressive, curative, and prophylactic potentials of an antimalarial polyherbal mixture and its individual components in Plasmodium berghei-Infected mice

September 23, 2021 - 11:33 -- NOT Open Access
Alaribe SC, Oladipupo AR, Uche GC, Onumba MU, Ota D, Awodele O, Oyibo WA
J Ethnopharmacol. 2021 Sep 15;277:114105

Malaria remains one of the most prevalent infectious diseases in tropical regions of the world, particularly in sub-Saharan Africa, where it remains epidemiologically holoendemic. The absence of effective vaccines and Plasmodium resistance to antimalarial drugs have been the major challenges to malaria control measures. An alternative strategy could be the application of validated and standardized herbal formulations.

Urban malaria in sub-Saharan Africa: dynamic of the vectorial system and the entomological inoculation rate

September 8, 2021 - 17:28 -- Open Access
P. Doumbe-Belisse, E. Kopya, C. S. Ngadjeu, N. Sonhafouo-Chiana, A. Talipouo, L. Djamouko-Djonkam, H. P. Awono-Ambene, C. S. Wondji, F. Njiokou and C. Antonio-Nkondjio
Malaria Journal 2021 20:364, 8 September 2021

Sub-Saharan Africa is registering one of the highest urban population growth across the world. It is estimated that over 75% of the population in this region will be living in urban settings by 2050. However, it is not known how this rapid urbanization will affect vector populations and disease transmission. The present study summarizes findings from studies conducted in urban settings between the 1970s and 2020 to assess the effects of urbanization on the entomological inoculation rate pattern and anopheline species distribution.

Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey

September 8, 2021 - 16:23 -- Open Access
Jean Baptiste Yaro, Alphonse Ouedraogo, Amidou Diarra, Salif Sombié, Z. Amidou Ouedraogo, Issa Nébié, Chris Drakeley, Sodiomon B. Sirima, Alfred B. Tiono, Steven W. Lindsay and Anne L. Wilson
Malaria Journal 2021 20:362, 6 September 2021

Malaria in pregnancy remains a public health problem in sub-Saharan Africa. Identifying risk factors for malaria in pregnancy could assist in developing interventions to reduce the risk of malaria in Burkina Faso and other countries in the region.

Threats to the effectiveness of insecticide-treated bednets for malaria control: thinking beyond insecticide resistance

September 1, 2021 - 17:21 -- Open Access
Lindsay SW, Thomas MB, Kleinschmidt I
Lancet Glob Health. 2021 Sep;9(9):e1325-e1331

From 2004 to 2019, insecticide-treated bednets (ITNs) have been the most effective tool for reducing malaria morbidity and mortality in sub-Saharan Africa. Recently, however, the decline in malaria cases and deaths has stalled. Some suggest that this inertia is due to increasing resistance in malaria vectors to the pyrethroid insecticides used for treating ITNs.


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