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Not Open Access | Dihydroartemisinin-piperaquine chemoprevention and malaria incidence after severe flooding: evaluation of a pragmatic intervention in rural Uganda

September 14, 2021 - 09:22 -- NOT Open Access
Boyce RM, Hollingsworth BD, Mulogo EM, et al.
Clin Infect Dis. 2021 Sep 9:ciab781

Malaria epidemics are a well-described phenomenon after extreme precipitation and flooding, which account for nearly half of global disasters over the past two decades. Yet few studies have examined mitigation measures to prevent post-flood malaria epidemics.

NOT Open Access | Decreased susceptibility to dihydrofolate reductase inhibitors associated with genetic polymorphisms in Ugandan Plasmodium falciparum isolates

September 1, 2021 - 16:10 -- NOT Open Access
Kreutzfeld O, Tumwebaze PK, Rosenthal PJ, et al.
J Infect Dis. 2021 Aug 30:jiab435

The Plasmodium falciparum dihydrofolate reductase (PfDHFR) inhibitors pyrimethamine and cycloguanil (the active metabolite of proguanil) have important roles in malaria chemoprevention, but drug resistance challenges their efficacies. A new compound, P218, was designed to overcome resistance, but drug susceptibility data for P. falciparum field isolates are limited.

Predatory and competitive interaction in Anopheles gambiae sensu lato larval breeding habitats in selected villages of central Uganda

August 25, 2021 - 15:57 -- Open Access
Onen H, Odong R, Chemurot M, Tripet F, Kayondo JK
Parasit Vectors. 2021 Aug 21;14(1):420

Malaria is often persistent in communities surrounded by mosquito breeding habitats. Anopheles gambiae sensu lato exploit a variety of aquatic habitats, but the biotic determinants of its preferences are poorly understood. This study aimed to identify and quantify macroinvertebrates in different habitat types with determined water physico-chemical parameters to establish those preferred by An. gambiae s.l. larvae as well as their predators and competitors.

An assessment of the knowledge, practices and resources during the delivery of malaria health care services among private health care practitioners: a cross section study in the Mid-Western Region of Uganda

August 17, 2021 - 15:31 -- Open Access
Wanzira H, Tumwine D, Bukoma P, Musiime A, Biculu J, Ediamu T, Gudoi S, Tibenderana JK, Mulebeke R, Nantanda R, Achan J
BMC Health Serv Res. 2021 Aug 10;21(1):788

Approximately 50 % of the population in Uganda seeks health care from private facilities but there is limited data on the quality of care for malaria in these facilities. This study aimed to document the knowledge, practices and resources during the delivery of malaria care services, among private health practitioners in the Mid-Western region of Uganda, an area of moderate malaria transmission.

NOT Open Access | Linking microbiota composition with antimalarial antibody response

August 17, 2021 - 14:34 -- NOT Open Access
Romoli O, Mancio-Silva L, Gendrin M
Trends Parasitol. 2021 Aug 11:S1471-4922(21)00172-0

Microbiota composition recently arose as a factor correlating with malaria infection. Mandal et al. showed, via cecal transplant and antibacterial treatment, that the mouse microbiota modulates parasitemia by affecting spleen germinal centers where B cells are matured. They further identified correlations between microbiota composition and malaria severity in Ugandan children.

NOT Open Access | Daily Training efficiency during computerized cognitive rehabilitation training (CCRT): an analysis from a randomized trial in Ugandan children with and without severe malaria

August 17, 2021 - 14:30 -- NOT Open Access
Larrivey V, Neva J, Finn K, Sikorskii A, Familiar-Lopez I, Ucheagwu V, Ezeamama A, Ruisenor-Escudero H, Nakasujja N, Boivin M, Giordani B
Child Neuropsychol. 2021 Aug 11:1-15

Children in Uganda are at risk for significant cognitive sequelae from severe malaria. Computerized cognitive rehabilitation training (CCRT) represents a potential method to improve working memory, behavior, and executive functioning, cognitive domains most at risk following severe malaria. The primary aim of this study was to complete a secondary analysis of data from a concluded CCRT randomized control trial in order to compare the training efficiency of a commonly used CCRT program under conditions of titrated (adaptive) or non-titrated (non-adaptive) training and with children with increasing malaria severity to determine how various factors may affect potential CCRT improvement.

Integrated malaria prevention in rural communities in Uganda: a qualitative feasibility study for a randomised controlled trial

August 17, 2021 - 14:28 -- Open Access
Musoke D, Namata C, Ndejjo R, Ssempebwa JC, Musoke MB
Pilot Feasibility Stud. 2021 Aug 10;7(1):155

A randomised controlled trial (RCT) on integrated malaria prevention, which advocates the use of several malaria prevention methods holistically, has been proposed. However, before conducting an RCT, it is recommended that a feasibility study is carried out to provide information to support the main study, particularly for such a complex intervention. Therefore, a feasibility study for an RCT on integrated malaria prevention in Uganda was conducted.

NOT Open Access | Associations between varied susceptibilities of PfATP4 inhibitors and genotypes in Ugandan Plasmodium falciparum isolates

August 4, 2021 - 15:56 -- NOT Open Access
Kreutzfeld O, Rasmussen SA, Rosenthal PJ, et al.
Antimicrob Agents Chemother. 2021 Aug 2:AAC0077121

Among novel compounds under recent investigation as potential new antimalarial drugs are three independently developed inhibitors of the Plasmodium falciparum P-type ATPase (PfATP4): KAE609 (cipargamin), PA92, and SJ733. We assessed ex vivo susceptibilities to these compounds of 374 fresh P. falciparum isolates collected in Tororo and Busia districts, Uganda from 2016-2019. Median IC50s were 65 nM for SJ733, 9.1 nM for PA92, and 0.5 nM for KAE609. Sequencing of pfatp4 for 218 of these isolates demonstrated many non-synonymous single nucleotide polymorphisms; the most frequent mutations were G1128R (69% of isolates mixed or mutant), Q1081K/R (68%), G223S (25%), N1045K (16%) and D1116G/N/Y (16%).

Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria

August 4, 2021 - 15:44 -- Open Access
Conroy AL, Opoka RO, Bangirana P, Namazzi R, Okullo AE, Georgieff MK, Cusick S, Idro R, Ssenkusu JM, John CC
BMC Med. 2021 Jul 28;19(1):168

In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing mortality compared to quinine. There are limited data on long-term clinical and neurobehavioral outcomes after artemisinin use for treatment of SM.

Does subsidizing the private for-profit sector benefit the poor? Evidence from national antimalarial subsidies in Nigeria and Uganda

July 28, 2021 - 12:49 -- Open Access
Tougher S, Hanson K, Goodman CA
Health Econ. 2021 Jul 22

Subsidising quality-assured artemisinin combination therapies (QAACTs) for distribution in the for-profit sector is a controversial strategy for improving access. The Affordable Medicines Facility-malaria (AMFm) was the largest initiative of this kind. We assessed the equity of AMFm in two ways using nationally representative household survey data on care seeking for children from Nigeria and Uganda.


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