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The use of respondent‑driven sampling to assess febrile illness treatment-seeking behaviours among forest-goers in Cambodia and Vietnam

January 12, 2022 - 22:56 -- Open Access
Mahesh Paudel, Kemi Tesfazghi, Hoa Nguyen, Sochea Phok, Shwetha Srinivasan and Jennifer Wheeler
Malaria Journal 2021 20:477, 20 December 2021

Countries in the Greater Mekong sub-region (GMS) aim to eliminate all forms of malaria by 2030. In Cambodia and Vietnam, forest-goers are at an increased risk of malaria. Universal access to prompt diagnosis and treatment is a core malaria intervention. This can only be achieved by understanding the healthcare-seeking behaviour among the most vulnerable groups and eliminating barriers to prompt and effective treatment. This study aimed to explore healthcare-seeking behaviours for febrile illness among populations at risk for malaria in Cambodia and Vietnam.

Entomological survey in two communes with residual malaria transmission in Gia Lai Province in the central highlands of Vietnam

October 29, 2021 - 14:11 -- Open Access
Thai Quang Nguyen, Manh Duc Nguyen, Vinh Xuan Pham, Huan Mah Ro, Michael D. Edstein, Weng K. Chow, Nicholas J. Martin, Jeffrey C. Hertz and Maysa T. Motoki
Malaria Journal 2021 20:403, 16 October 2021

In 2018, the National Malaria Control Programme in Vietnam switched from prioritizing malaria control to elimination. However, with the ongoing elimination programme, there are still areas where residual malaria transmission persists, including the central highlands. This entomological survey was conducted to evaluate Anopheles diversity and host-seeking activity of Anopheles vectors in two communes with very low malaria transmission in Gia Lai Province.

Risk factors for malaria in high incidence areas of Viet Nam: a case–control study

October 6, 2021 - 20:02 -- Open Access
Richard J. Maude, Thang Duc Ngo, Nicholas J. Martin, et al.
Malaria Journal 2021 20:373, 17 September 2021

A key step to advancing the goal of malaria elimination in Viet Nam by 2030 is focusing limited resources for treatment and prevention to groups most at risk for malaria transmission.

Pyronaridine-Artesunate (Pyramax) for the Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam

October 5, 2021 - 10:48 -- Open Access
Manh ND, Thanh NV, Quang HH, Van NTT, San NN, Phong NC, Birrell GW, Edstein MD, Edgel KA, Martin NJ, Chavchich M
Antimicrob Agents Chemother. 2021 Sep 27:AAC0027621

The rise in Plasmodium falciparum resistance to dihydroartemisinin-piperaquine in Vietnam justifies the need to evaluate alternative artemisinin-based combination therapies. Between July 2018 and October 2019, a single-arm trial of pyronaridine-artesunate (Pyramax, PA) was conducted in Dak Nong province, Vietnam. PA (3-day course) was administered to adults and children infected with P. falciparum. PA was well tolerated by the participants. The proportion of patients with Day 42 PCR-corrected adequate clinical and parasitological response was 95.2% (95% confidence interval [CI], 82.3 to 98.8, n = 40/42) for treating falciparum malaria.

NOT Open Access | Molecular surveillance of malaria in the Central Highlands, Vietnam

August 4, 2021 - 16:06 -- NOT Open Access
Võ TC, Lê HG, Kang JM, Naw H, Fan CK, Trinh NTM, Quang HH, Na BK
Parasitol Int. 2021 Aug;83:102374

Vietnam achieved outstanding success against malaria in the last few decades. The mortality and morbidity of malaria in Vietnam have decreased remarkably in recent years, but malaria is still a major public health concern in the country, particularly in the Central Highlands region. In this study, molecular analyses of malaria parasites in the Central Highlands were performed to understand the population structure and genetic diversity of the parasites circulating in the region.

Mosquitoes (Diptera: Culicidae) from Villages and Forest Areas of Rural Communes in Khanh Hoa and Binh Phuoc Provinces, Vietnam

June 22, 2021 - 14:19 -- Open Access
Vu NS, Hertz JC, Martin NJ, Tran TC, Fiorenzano JM, Tran PV, Nguyen HV, Dang AD, Tran DN, Motoki MT
J Med Entomol. 2021 Jun 18:tjab106

This study presents the diversity of mosquitoes collected from communes, endemic with malaria and dengue, located in Khanh Hoa and Binh Phuoc Provinces, Vietnam. A total of 10,288 mosquitoes were collected in the village and forested sites using standard larval dippers, cow-baited traps, ultra-violet light traps, and mechanical aspirators. Mosquito taxa were identified morphologically and species complexes/groups were further characterized molecularly.

Predictors of treatment failures of plasmodium falciparum malaria in Vietnam: a 4-year single‐centre retrospective study

May 6, 2021 - 07:11 -- Open Access
Minh Cuong Duong, Oanh Kieu Nguyet Pham, Phong Thanh Nguyen, Van Vinh Chau Nguyen and Phu Hoan Nguyen
Malaria Journal 2021 20:205, 29 April 2021

Drug-resistant falciparum malaria is an increasing public health burden. This study examined the magnitude of Plasmodium falciparum infection and the patterns and predictors of treatment failure in Vietnam.

Ivermectin Treatment for Cattle Reduced the Survival of Two Malaria Vectors, Anopheles dirus and Anopheles epiroticus, Under Laboratory Conditions in Central Vietnam

April 28, 2021 - 13:51 -- Open Access
Cramer EY, Quang NX, Hertz JC, Van Nguyen D, Quang HH, Mendenhall I, Lover AA
Am J Trop Med Hyg. 2021 Apr 26:tpmd201239

Ivermectin is a low-cost and nontoxic mosquitocide that may have a role in malaria elimination. However, the extent to which this drug impacts the mortality of Anopheles dirus and Anopheles epiroticus, two important malaria vectors in Southeast Asia, is unknown. This study compared quantified anopheline mortality after feeding on ivermectin-treated cattle and control cattle in Vietnam.

Results from a malaria indicator survey highlight the importance of routine data capture in high-risk forest and farm transmission sites in Vietnam to tailor location-specific malaria elimination interventions

April 22, 2021 - 08:33 -- Open Access
Ngo TD, Canavati SE, Dung DV, Vo TH, Tran DT, Tran LK, Whedbee RJ, Milgotina EI, Kelly GC, Edgel KA, Martin NJ
PLoS One. 2021 Apr 16;16(4):e0250045

In-line with the World Health Organization's (WHO) Global Technical Strategy for Malaria (2016-2030), Vietnam is striving to eliminate malaria by 2030. Targeting appropriate interventions in high-risk populations such as forest and forest-fringe communities is a critical component of malaria elimination efforts in Vietnam. In 2016, a household-level malaria indicator survey was conducted in Phu Yen Province, Vietnam with the aim of assessing the knowledge, behaviors and associated risks of malaria infection among priority mobile and migrant populations (MMPs) working and sleeping in forests and on farms.

Mosquito Net Ownership, Utilization, and Preferences among Mobile and Migrant Populations Sleeping in Forests and Farms in Central Vietnam: A Cross-Sectional Study

April 6, 2021 - 14:12 -- Open Access
Canavati SE, Kelly GC, Vo TH, Tran LK, Ngo TD, Tran DT, Edgel KA, Martin NJ
Am J Trop Med Hyg. 2021 Apr 5:tpmd200711

Strengthening vector control measures among mobile and migrant populations (MMPs) is crucial to malaria elimination, particularly in areas with multidrug-resistant malaria. Although a global priority, providing access and ensuring high coverage of available tools such as long-lasting insecticidal nets (LLINs) among these vulnerable groups remains a significant challenge. We assessed mosquito net ownership, utilization, and preference among individuals who slept in a forest and/or on a farm against those residing only in village "home" settings in a priority malaria elimination area of Vietnam.


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