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Sub-national disparities in accessing anti-malarial drug treatment in eastern Indonesia

August 17, 2021 - 15:15 -- Open Access
Ipa M, Laksono AD, Astuti EP, Prasetyowati H, Pradani FY, Hendri J, Ruliansyah A, Surendra H, Elyazar IRF
BMC Public Health. 2021 Aug 13;21(1):1548

Poor access to health care providers was among the contributing factors to less prompt and ineffective malaria treatment. This limitation could cause severe diseases in remote areas. This study examined the sub-national disparities and predictors in accessing anti-malarial drug treatment among adults in Eastern Indonesia.

Genotypes and phenotypes of G6PD deficiency among Indonesian females across diagnostic thresholds of G6PD activity guiding safe primaquine therapy of latent malaria

July 20, 2021 - 13:04 -- Open Access
Satyagraha AW, Sadhewa A, Panggalo LV, Subekti D, Elyazar I, Soebianto S, Mahpud N, Harahap AR, Baird JK
PLoS Negl Trop Dis. 2021 Jul 16;15(7):e0009610

Plasmodium vivax occurs as a latent infection of liver and a patent infection of red blood cells. Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies. The hypnozoitocidal therapies available are primaquine and tafenoquine, 8-aminoquinoline drugs that can provoke threatening acute hemolytic anemia in patients having an X-linked G6PD-deficiency. Heterozygous females may screen as G6PD-normal prior to radical cure and go on to experience hemolytic crisis.

Epidemiology of Malaria in East Nusa Tenggara Province in Indonesia: Protocol for a Cross-sectional Study

April 14, 2021 - 08:12 -- Open Access
Guntur RD, Kingsley J, Islam FMA
JMIR Res Protoc. 2021 Apr 9;10(4):e23545

Malaria is a global pandemic that results in approximately 228 million cases globally; 3.5% of these cases are in Southeast Asian countries, including Indonesia. Following the World Health Organization (WHO) initiative, Indonesia is in the process of achieving malaria-free zone status by 2030. However, the eastern part of Indonesia, including the East Nusa Tenggara Province (ENTP), still has a disproportionately high rate of malaria.

Allelic diversity of merozoite surface protein genes (msp1 and msp2) and clinical manifestations of Plasmodium falciparum malaria cases in Aceh, Indonesia

April 14, 2021 - 08:00 -- Open Access
Kurnia Fitri Jamil, Nandha Rizki Pratama, Din Syafruddin, et al.
Malaria Journal 2021 20:182, 13 April 2021

The malaria control programme in Indonesia has successfully brought down malaria incidence in many parts in Indonesia, including Aceh Province. Clinical manifestation of reported malaria cases in Aceh varied widely from asymptomatic, mild uncomplicated to severe and fatal complications. The present study aims to explore the allelic diversity of merozoite surface protein 1 gene (msp1) and msp2 among the Plasmodium falciparum isolates in Aceh Province and to determine their potential correlation with the severity of malaria clinical manifestation.

Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study

April 14, 2021 - 07:50 -- Open Access
Ayleen Kosasih, Cristian Koepfli, M. Sopiyudin Dahlan, William A. Hawley, J. Kevin Baird, Ivo Mueller, Neil F. Lobo and Inge Sutanto
Malaria Journal 2021 20:177, 9 April 2021

A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia.

A participatory approach to address within‐country cross‐border malaria: the case of Menoreh Hills in Java, Indonesia

March 10, 2021 - 15:13 -- Open Access
Riris Andono Ahmad, Astri Ferdiana, Henry Surendra, Tyrone Reden Sy, Deni Herbianto, Theodola Baning Rahayujati, Dwi Sarwani Sri Rejeki and E. Elsa Herdiana Murhandarwati
Malaria Journal 2021 20:137, 6 March 2021

Malaria remains a significant public health issue in Indonesia. Most of the endemic areas are in the eastern parts of Indonesia, but there are a few remaining foci of persistent endemic malaria in Java, particularly in Menoreh Hills, a region bordering three districts of two provinces on this island. Despite a commitment to build a partnership to eliminate cross-border malaria, there is a lack of understanding of how this partnership might be translated into an implementable strategic plan. The study aims to provide evidence of how a participatory approach was used to strengthen the cross-border collaboration and stakeholders’ capacity to develop a joint strategic, operational, and costing plan for cross-border malaria elimination.

Haematological profile of children with malaria in Sorong, West Papua, Indonesia

March 10, 2021 - 13:58 -- Open Access
Syilvia Jiero and Ayodhia Pitaloka Pasaribu
Malaria Journal 2021 20:126, 4 March 2021

Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria.

NOT Open Access | Alkaloids from the root of Indonesian Annona muricata L

February 3, 2021 - 14:39 -- NOT Open Access
Nugraha AS, Haritakun R, Lambert JM, Dillon CT, Keller PA
Nat Prod Res. 2021 Feb;35(3):481-489

Annona muricata L. has been used traditionally in Indonesia to treat disease. Phytochemical studies on the alkaloid fractions from the root of Annona muricata L. from Malang-Indonesia resulted in the isolation of an unreported benzylisoquinoline alkaloid (+)-xylopine 5 as well as four known alkaloids (1-4).

Cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine versus single screening and treatment for the control of malaria in pregnancy in Papua, Indonesia: a provider perspective analysis from a cluster-randomised trial

December 3, 2020 - 12:26 -- Open Access
Paintain L, Hill J, Webster J, et al.
Lancet Glob Health. 2020 Dec;8(12):e1524-e1533

Malaria infection during pregnancy is associated with serious adverse maternal and birth outcomes. A randomised controlled trial in Papua, Indonesia, comparing the efficacy of intermittent preventive treatment with dihydroartemisinin-piperaquine with the current strategy of single screening and treatment showed that intermittent preventive treatment is a promising alternative treatment for the reduction of malaria in pregnancy. We aimed to estimate the incremental cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine compared with single screening and treatment with dihydroartemisinin-piperaquine.

Significant Symptoms and Non-Symptom-Related Factors for Malaria Diagnosis in Endemic Regions of Indonesia

December 3, 2020 - 12:15 -- Open Access
Bria YP, Yeh CH, Bedingfield S
Int J Infect Dis. 2020 Nov 26:S1201-9712(20)32490-5

This study aims to identify significant symptoms and non-symptom-related factors for malaria diagnosis in endemic regions of Indonesia.


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