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NOT Open Access | patiotemporal Dynamic of the RTS,S/AS01 Malaria Vaccine Target Antigens in Senegal

October 16, 2021 - 20:00 -- NOT Open Access
Diallo MA, L'Ollivier C, Diongue K, Badiane AS, Kodio A, Tall ML, Sy M, Seck MC, Sene D, Ndiaye M, Fall FB, Ranque S, Ndiaye D
Am J Trop Med Hyg. 2021 Oct 11:tpmd210369

The RTS,S/AS01 malaria vaccine confers only moderate protection against malaria. Evidence suggests that the effectiveness of the RTS,S/AS01 vaccine depends upon the parasite population genetics, specifically regarding the circumsporozoite protein haplotypes in the population. We investigated Plasmodium falciparum circumsporozoite protein (PfCSP) gene sequences from two endemic sites in 2018 in Senegal.

Knowledge, attitudes and practices (KAP) to assess the impact of school children's awareness of malaria using the MOSKI KIT® tool: study case of some Dakar schools in Senegal

July 14, 2021 - 11:04 -- Open Access
Isaac Akhénaton Manga, Aïssatou Gaye, Aliou Dia, Ekoue Kouevidjin, Maria Rosa Dos Reis, Aboubakry Sadikh Niang, Amy Ndao Fall, Christelle Maitre Anquetil and Jean Louis Abdourahim Ndiaye
Malaria Journal 2021 20:310, 10 July 2021

MOSKI KIT® is a fun tool designed to interest children for prevention and management of malaria. This study was carried out with the objective to assess the short- and long-term impacts of this tool on the knowledge, attitudes, and practices of school children, and on the transmission of the knowledge received at the household level as well.

High prevalence of asymptomatic Plasmodium infection in Bandafassi, South-East Senegal

May 18, 2021 - 13:37 -- Open Access
Aida Sadikh Badiane, Tolla Ndiaye, Alphonse Birane Thiaw, Deme Awa Binta, Mamadou Alpha Diallo, Mame Cheikh Seck, Khadim Diongue, Mamane Nassirou Garba, Mouhamadou Ndiaye and Daouda Ndiaye
Malaria Journal 2021 20:218, 12 May 2021

Malaria control and elimination strategies are based on levels of transmission that are usually determined by data collected from health facilities. In endemic areas, asymptomatic Plasmodium infection is thought to represent the majority of infections, though they are not diagnosed nor treated. Therefore, there might be an underestimation of the malaria reservoir, resulting in inadequate control strategies. In addition, these untreated asymptomatic Plasmodium infections maintain transmission, making it difficult or impossible to reach malaria elimination goals. Thus, the aim of this study was to determine the prevalence of asymptomatic Plasmodium infections in southeastern Senegal.

Review of Issues on Residual Malaria Transmission

April 29, 2021 - 08:47 -- Open Access
Carnevale P, Manguin S
J Infect Dis. 2021 Apr 27;223(Supplement_2):S61-S80

Residual malaria transmission is the actual maintained inoculation of Plasmodium, in spite of a well-designed and implemented vector control programs, and is of great concern for malaria elimination. Residual malaria transmission occurs under several possible circumstances, among which the presence of exophilic vector species, such as Anopheles dirus, or indoor- and outdoor-biting vectors, such as Anopheles nili, or specific behavior, such as feeding on humans indoors, then resting or leaving the house the same night (such as Anopheles moucheti) or also changes in behavior induced by insecticides applied inside houses, such as the well-known deterrent effect of permethrin-treated nets or the irritant effect of DDT.

Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal

March 31, 2021 - 14:26 -- Open Access
Ahouidi A, Oliveira R, Lobo L, Diedhiou C, Mboup S, Nogueira F
PLoS One. 2021 Mar 26;16(3):e0249357

Delayed Plasmodium falciparum parasite clearance has been associated with Single Nucleotide Polymorphisms (SNPs) in the kelch protein propeller domain (coded by pfk13 gene). SNPs in the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) are associated with multi-drug resistance including the combination artemether-lumefantrine. To our knowledge, this is the first work providing information on the prevalence of k13-propeller and pfmdr1 mutations from Sédhiou, a region in the south of Senegal.

Genomic investigation of atypical malaria cases in Kanel, northern Senegal

February 23, 2021 - 14:10 -- Open Access
Mouhamad Sy, Aida Sadikh Badiane, Doudou Sène, et al.
Malaria Journal 2021 20:103, 19 February 2021

The diagnosis of malaria cases in regions where the malaria burden has decreased significantly and prevalence is very low is more challenging, in part because of reduced clinical presumption of malaria. The appearance of a cluster of malaria cases with atypical symptoms in Mbounguiel, a village in northern Senegal where malaria transmission is low, in September 2018 exemplifies this scenario. The collaboration between the National Malaria Control Programme (NMCP) at the Senegal Ministry of Health and the Laboratory of Parasitology and Mycology at Cheikh Anta Diop University worked together to evaluate this cluster of malaria cases using molecular and serological tools.

Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations

January 13, 2021 - 10:18 -- Open Access
Mary A. Oboh, Tolla Ndiaye, Daouda Ndiaye, et al.
Malaria Journal 2021 20:38, 13 January 2021

Characterizing the genetic diversity of malaria parasite populations in different endemic settings (from low to high) could be helpful in determining the effectiveness of malaria interventions. This study compared Plasmodium falciparum parasite population diversity from two sites with low (pre-elimination) and high transmission in Senegal and Nigeria, respectively.

Targeting Malaria Hotspots to Reduce Transmission Incidence in Senegal

January 1, 2021 - 15:54 -- Open Access
Sallah K, Giorgi R, Ba EH, Piarroux M, Piarroux R, Cisse B, Gaudart J
Int J Environ Res Public Health. 2020 Dec 24;18(1):E76

In central Senegal, malaria incidence declined in response to scaling-up of control measures from 2000 to 2010 and has since remained stable, making elimination unlikely in the short term. Additional control measures are needed to reduce transmission. We simulated chemoprophylaxis interventions targeting malaria hotspots using a metapopulation mathematical model, based on a differential-equation framework and incorporating human mobility. The model was fitted to weekly malaria incidence from 45 villages.

Mapping the breeding sites of Anopheles gambiae s. l. in areas of residual malaria transmission in central western Senegal

December 15, 2020 - 14:43 -- Open Access
Ndiaye A, Niang EHA, Diène AN, Nourdine MA, Sarr PC, Konaté L, Faye O, Gaye O, Sy O
PLoS One. 2020 Dec 11;15(12):e0236607

Despite the deployment of several effective control interventions in central-western Senegal, residual malaria transmission is still occurring in some hotspots. To better tailor targeted control actions, it is critical to unravel the underlying environmental and geographical factors that cause the persistence infection in hotspot villages. "Hotspots villages" were defined in our study as those reporting more than six indigenous malaria cases during the previous year. A total of ten villages, including seven hotspots and three non-hotspots, were surveyed.

Molecular epidemiology of Plasmodium falciparum by multiplexed amplicon deep sequencing in Senegal

November 11, 2020 - 14:30 -- Open Access
Tolla Ndiaye, Mouhamad Sy, Daouda Ndiaye, et al.
Malaria Journal 2020 19:403, 10 November 2020

Molecular epidemiology can provide important information regarding the genetic diversity and transmission of Plasmodium falciparum, which can assist in designing and monitoring elimination efforts. However, malaria molecular epidemiology including understanding the genetic diversity of the parasite and performing molecular surveillance of transmission has been poorly documented in Senegal. Next Generation Sequencing (NGS) offers a practical, fast and high-throughput approach to understand malaria population genetics. This study aims to unravel the population structure of P. falciparum and to estimate the allelic diversity, multiplicity of infection (MOI), and evolutionary patterns of the malaria parasite using the NGS platform.


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