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Intermittent preventive treatment for malaria in infants

July 21, 2021 - 17:07 -- Open Access
Esu EB, Oringanje C, Meremikwu MM
Cochrane Database Syst Rev. 2021 Jul 17;7:CD011525

Intermittent preventive treatment could help prevent malaria in infants (IPTi) living in areas of moderate to high malaria transmission in sub-Saharan Africa. The World Health Organization (WHO) policy recommended IPTi in 2010, but its adoption in countries has been limited.

Rapid Screening for Non-falciparum Malaria in Elimination Settings Using Multiplex Antigen and Antibody Detection: Post Hoc Identification of Plasmodium malariae in an Infant in Haiti

April 7, 2021 - 12:28 -- Open Access
van den Hoogen LL, Herman C, Ashton RA, et al.
Am J Trop Med Hyg. 2021 Apr 5:tpmd201450

Haiti is targeting malaria elimination by 2025. The Grand'Anse department in southwestern Haiti experiences one-third to half of all nationally reported Plasmodium falciparum cases. Although there are historical reports of Plasmodium vivax and Plasmodium malariae, today, non-falciparum infections would remain undetected because of extensive use of falciparum-specific histidine-rich protein 2 (HRP2) rapid diagnostic tests (RDT) at health facilities. A recent case-control study was conducted in Grand'Anse to identify risk factors for P. falciparum infection using HRP2-based RDTs (n = 1,107).

Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso

February 17, 2021 - 09:04 -- Open Access
Hamatandi Magloire Natama, Eduard Rovira-Vallbona, Anna Rosanas-Urgell, et al.
Malaria Journal 2021 20:94, 16 February 2021

Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of their adaptive immune system, the protective effect of maternal antibodies and fetal haemoglobin. This study investigated the association between genetic variation in innate immune response genes and malaria susceptibility during the first year of life in 656 infants from a birth cohort survey performed in Nanoro, Burkina Faso.

Evaluation of health system readiness and coverage of intermittent preventive treatment of malaria in infants (IPTi) in Kambia district to inform national scale-up in Sierra Leone

February 8, 2021 - 10:57 -- Open Access
Maria Lahuerta, Roberta Sutton, Laura Steinhardt, et al.
Malaria Journal 2021 20:74, 6 February 2021

Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a proven strategy to protect infants against malaria. Sierra Leone is the first country to implement IPTi nationwide. IPTi implementation was evaluated in Kambia, one of two initial pilot districts, to assess quality and coverage of IPTi services.

Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

September 10, 2019 - 15:34 -- Open Access
Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan
Malaria Journal 2019 18:304, 3 September 2019

Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp), on the risk of clinical malaria or parasitaemia during infancy.


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