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Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis

September 1, 2021 - 16:38 -- Open Access
Fatoumata O. Maiga, Mamadou Wele, Jeffrey G. Shaffer, et al.
Malaria Journal 2021 20:356, 30 August 2021

Artemisinin-based combination therapy (ACT) was deployed in 2005 as an alternative to chloroquine and is considered the most efficacious treatment currently available for uncomplicated falciparum malaria. While widespread artemisinin resistance has not been reported to date in Africa, recent studies have reported partial resistance in Rwanda. The purpose of this study is to provide a current systematic review and meta-analysis on ACT at Mali study sites, where falciparum malaria is highly endemic.

Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

July 20, 2021 - 11:54 -- Open Access
Ventimiglia NT, Stucke EM, Travassos MA, et al.
Sci Rep. 2021 Jul 13;11(1):14401

Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-CD36-binding PfEMP1s are associated with protection against severe disease.

Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLgamma11 and DBLdelta-1 Predict Reduction in Parasite Density

June 16, 2021 - 14:53 -- Open Access
Araj BN, Swihart B, Fried M, et al.
mSystems. 2021 Jun 15:e0034721

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen family expressed on infected red blood cells that plays a role in immune evasion and mediates adhesion to vascular endothelium. PfEMP1s are potential targets of protective antibodies as suggested by previous seroepidemiology studies. Here, we used previously reported proteomic analyses of PfEMP1s of clinical parasite isolates collected from Malian children to identify targets of immunity.

NOT Open Access | Plasmodium malariae and Plasmodium falciparum comparative susceptibility to antimalarial drugs in Mali

May 26, 2021 - 09:43 -- NOT Open Access
Dembele L, Aniweh Y, Djimde AA, et al.
J Antimicrob Chemother. 2021 May 22:dkab133

To evaluate Plasmodium malariae susceptibility to current and lead candidate antimalarial drugs.

Therapeutic efficacy of artemether–lumefantrine and artesunate–amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali, 2015–2016

May 26, 2021 - 09:33 -- Open Access
Youssouf Diarra, Oumar Koné, Ousmane A. Koita, et al.
Malaria Journal 2021 20:235, 25 May 2021

The current first-line treatments for uncomplicated malaria recommended by the National Malaria Control Programme in Mali are artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ). From 2015 to 2016, an in vivo study was carried out to assess the clinical and parasitological responses to AL and ASAQ in Sélingué, Mali.

Determinants of intermittent preventive treatment with sulfadoxine–pyrimethamine in pregnant women (IPTp-SP) in Mali, a household survey

May 26, 2021 - 09:22 -- Open Access
Oumar Sangho, Moctar Tounkara, Lillian Joyce Whiting-Collins, Madeleine Beebe, Peter J. Winch and Seydou Doumbia
Malaria Journal 2021 20:231, 22 May 2021

In malaria endemic regions, intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for all pregnant women during prenatal consultation, from the fourth month of pregnancy up to the time of delivery. The Government of Mali is aiming for universal coverage of IPTp-SP. However, coverage is still low, estimated to be 18% for completion of three doses (IPTp-SP3). The objective of this study was to identify the factors that influence IPTp-SP adherence in the Health District of Sélingué, Mali.

NOT Open Access | Experimenting with co-development: A qualitative study of gene drive research for malaria control in Mali

May 5, 2021 - 10:16 -- NOT Open Access
Hartley S, Ledingham K, Owen R, Leonelli S, Diarra S, Diop S
Soc Sci Med. 2021 May;276:113850

We investigate how technology 'co-development' (between researchers, stakeholders and local communities) is framed in practice by those developing gene drive mosquitos for malaria eradication. Our case study focuses on UK and Mali-based researchers planning to undertake the first field trials in Mali of gene drive mosquitos for malaria control. While they and the wider gene drive research community are explicitly committed to the principle of co-development, how this is framed and practiced is not clear.

Malaria infection is common and associated with perinatal mortality and preterm delivery despite widespread use of chemoprevention in Mali: an observational study 2010 to 2014

April 14, 2021 - 08:22 -- Open Access
Mahamar A, Andemel N, Fried M, et al.
Clin Infect Dis. 2021 Apr 13:ciab301

In malaria-endemic areas, pregnant women and especially first-time mothers are more susceptible to Plasmodium falciparum. Malaria diagnosis is often missed during pregnancy, since many women with placental malaria remain asymptomatic or have submicroscopic parasitemia, masking the association between malaria and pregnancy outcomes Severe maternal anemia and low birthweight deliveries are well-established sequelae, but few studies have confirmed the relationship between malaria infection and severe outcomes like perinatal mortality in high transmission zones.

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

March 23, 2021 - 14:35 -- Open Access
Coelho CH, Tang WK, Duffy PE, et al.
Nat Commun. 2021 Mar 19;12(1):1750

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development of P. falciparum parasites.

Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria

March 18, 2021 - 09:25 -- Open Access
Keith J. Fraser, Lazaro Mwandigha, Sekou F. Traore, Mohamed M. Traore, Seydou Doumbia, Amy Junnila, Edita Revay, John C. Beier, John M. Marshall, Azra C. Ghani and Gunter Müller
Malaria Journal 2021 20:151, 17 March 2021

Attractive targeted sugar baits (ATSBs) are a promising new tool for malaria control as they can target outdoor-feeding mosquito populations, in contrast to current vector control tools which predominantly target indoor-feeding mosquitoes.


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