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Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

September 23, 2021 - 09:19 -- Open Access
Wharton-Smith A, Baker K, Candrinho B, et al.
JMIR Res Protoc. 2021 Sep 15;10(9):e27855

Malaria is a significant cause of morbidity and mortality in children aged under 5 years in Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration of four monthly courses of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ), to children aged 3-59 months during rainy season. However, as resistance to SP is widespread in East and Southern Africa, SMC has so far only been implemented across the Sahel in West Africa.

Not Open Access | Dihydroartemisinin-piperaquine chemoprevention and malaria incidence after severe flooding: evaluation of a pragmatic intervention in rural Uganda

September 14, 2021 - 09:22 -- NOT Open Access
Boyce RM, Hollingsworth BD, Mulogo EM, et al.
Clin Infect Dis. 2021 Sep 9:ciab781

Malaria epidemics are a well-described phenomenon after extreme precipitation and flooding, which account for nearly half of global disasters over the past two decades. Yet few studies have examined mitigation measures to prevent post-flood malaria epidemics.

Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: Case-control studies in 5 countries

September 14, 2021 - 09:19 -- Open Access
Cairns M, Ceesay SJ, Milligan P, et al.
PLoS Med. 2021 Sep 8;18(9):e1003727

Seasonal malaria chemoprevention (SMC) has shown high protective efficacy against clinical malaria and severe malaria in a series of clinical trials. We evaluated the effectiveness of SMC treatments against clinical malaria when delivered at scale through national malaria control programmes in 2015 and 2016.

Combining malaria vaccination with chemoprevention: a promising new approach to malaria control

September 8, 2021 - 16:21 -- Open Access
Brian Greenwood, Matthew Cairns, Mike Chaponda, R. Matthew Chico, Alassane Dicko, Jean-Bosco Ouedraogo, Kamija S. Phiri, Feiko O. ter Kuile and Daniel Chandramohan
Malaria Journal 2021 20:361, 6 September 2021

Malaria control has stalled in a number of African countries and novel approaches to malaria control are needed for these areas. The encouraging results of a recent trial conducted in young children in Burkina Faso and Mali in which a combination of the RTS,S/AS01E malaria vaccine and seasonal malaria chemoprevention led to a substantial reduction in clinical cases of malaria, severe malaria, and malaria deaths compared with the administration of either intervention given alone suggests that there may be other epidemiological/clinical situations in which a combination of malaria vaccination and chemoprevention could be beneficial.

Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention

September 1, 2021 - 16:26 -- Open Access
Chandramohan D, Zongo I, Greenwood B, et al.
N Engl J Med. 2021 Aug 25

Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions of Africa.

Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness

July 28, 2021 - 15:09 -- Open Access
Koudraogo Bienvenue Yaméogo, Rakiswendé Serge Yerbanga, Jean Bosco Ouédraogo, et al.
Malaria Journal 2021 20:326, 27 July 2021

Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period. Whether the addition of azithromycin (AZ) to SMC could potentiate the benefit of the intervention was tested through a double-blind, randomized, placebo-controlled trial. The effect of SMC and the addition of AZ, on malaria transmission and on the life history traits of Anopheles gambiae mosquitoes have been investigated.

NOT Open Access | Prophylactic malaria chemoprevention reduces readmission and death rate in children previously admitted to hospital for treatment of severe anaemia

July 28, 2021 - 12:47 -- NOT Open Access
Murphy S
Arch Dis Child Educ Pract Ed. 2021 Jul 21:edpract-2021-322075

No abstract available

Malaria infection is common and associated with perinatal mortality and preterm delivery despite widespread use of chemoprevention in Mali: an observational study 2010 to 2014

April 14, 2021 - 08:22 -- Open Access
Mahamar A, Andemel N, Fried M, et al.
Clin Infect Dis. 2021 Apr 13:ciab301

In malaria-endemic areas, pregnant women and especially first-time mothers are more susceptible to Plasmodium falciparum. Malaria diagnosis is often missed during pregnancy, since many women with placental malaria remain asymptomatic or have submicroscopic parasitemia, masking the association between malaria and pregnancy outcomes Severe maternal anemia and low birthweight deliveries are well-established sequelae, but few studies have confirmed the relationship between malaria infection and severe outcomes like perinatal mortality in high transmission zones.

A Decline and Age Shift in Malaria Incidence in Rural Mali following Implementation of Seasonal Malaria Chemoprevention and Indoor Residual Spraying

March 2, 2021 - 15:29 -- Open Access
Coulibaly D, Guindo B, Thera MA, et al.
Am J Trop Med Hyg. 2021 Mar 1:tpmd200622

Many African countries have reported declines in malaria incidence, attributed to the implementation of control strategies. In Mali, artemisinin-based combination therapy (ACT) was introduced in 2004, and long-lasting insecticide-treated nets (LLINs) have been partially distributed free of charge since 2007. In the Malian town of Bandiagara, a study conducted from 2009 to 2013 showed a stable incidence of malaria compared with 1999, despite the implementation of ACTs and LLINs. Since 2016, seasonal malaria chemoprevention has been scaled up across the country.

Seasonal malaria chemoprevention in the Sahel subregion of Africa: a cost-effectiveness and cost-savings analysis

February 3, 2021 - 14:19 -- Open Access
Gilmartin C, Nonvignon J, Cairns M, Milligan P, Bocoum F, Winskill P, Moroso D, Collins D
Lancet Glob Health. 2021 Feb;9(2):e199-e208

The intermittent administration of seasonal malaria chemoprevention (SMC) is recommended to prevent malaria among children aged 3–59 months in areas of the Sahel subregion in Africa. However, the cost-effectiveness and cost savings of SMC have not previously been evaluated in large-scale studies.


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