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chemoprevention

Evaluation of pilot implementation of seasonal malaria chemoprevention on morbidity in young children in Northern Sahelian Ghana

November 23, 2021 - 09:28 -- Open Access
Author(s): 
Patrick O. Ansah, Nana A. Ansah, Abraham R. Oduro, et al.
Reference: 
Malaria Journal 2021 20:440, 18 November 2021

In Sahelian Africa, the risk of malaria increases with the arrival of the rains, particularly in young children. Following successful trials, the World Health Organization (WHO) recommended the use of seasonal malaria chemoprevention (SMC) in areas with seasonal peak in malaria cases. This study evaluated the pilot implementation of SMC in Northern Ghana.

Prevalence of malaria in an area receiving seasonal malaria chemoprevention in Niger

November 18, 2021 - 11:30 -- Open Access
Author(s): 
Matthew E. Coldiron, Bachir Assao, Ousmane Guindo, Nathan Sayinzoga-Makombe, Alena Koscalova, Esther Sterk, Michel Quere, Iza Ciglenecki, Ann Mumina, Salifou Atti, Céline Langendorf and Rebecca F. Grais
Reference: 
Malaria Journal 2021 20:419, 24 October 2021

Malaria transmission is highly seasonal in Niger. Despite the introduction of seasonal malaria chemoprevention (SMC) in the Magaria District, malaria incidence remains high, and the epidemiology of malaria in the community is not well-understood.

Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

September 23, 2021 - 09:19 -- Open Access
Author(s): 
Wharton-Smith A, Baker K, Candrinho B, et al.
Reference: 
JMIR Res Protoc. 2021 Sep 15;10(9):e27855

Malaria is a significant cause of morbidity and mortality in children aged under 5 years in Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration of four monthly courses of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ), to children aged 3-59 months during rainy season. However, as resistance to SP is widespread in East and Southern Africa, SMC has so far only been implemented across the Sahel in West Africa.

Not Open Access | Dihydroartemisinin-piperaquine chemoprevention and malaria incidence after severe flooding: evaluation of a pragmatic intervention in rural Uganda

September 14, 2021 - 09:22 -- NOT Open Access
Author(s): 
Boyce RM, Hollingsworth BD, Mulogo EM, et al.
Reference: 
Clin Infect Dis. 2021 Sep 9:ciab781

Malaria epidemics are a well-described phenomenon after extreme precipitation and flooding, which account for nearly half of global disasters over the past two decades. Yet few studies have examined mitigation measures to prevent post-flood malaria epidemics.

Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: Case-control studies in 5 countries

September 14, 2021 - 09:19 -- Open Access
Author(s): 
Cairns M, Ceesay SJ, Milligan P, et al.
Reference: 
PLoS Med. 2021 Sep 8;18(9):e1003727

Seasonal malaria chemoprevention (SMC) has shown high protective efficacy against clinical malaria and severe malaria in a series of clinical trials. We evaluated the effectiveness of SMC treatments against clinical malaria when delivered at scale through national malaria control programmes in 2015 and 2016.

Combining malaria vaccination with chemoprevention: a promising new approach to malaria control

September 8, 2021 - 16:21 -- Open Access
Author(s): 
Brian Greenwood, Matthew Cairns, Mike Chaponda, R. Matthew Chico, Alassane Dicko, Jean-Bosco Ouedraogo, Kamija S. Phiri, Feiko O. ter Kuile and Daniel Chandramohan
Reference: 
Malaria Journal 2021 20:361, 6 September 2021

Malaria control has stalled in a number of African countries and novel approaches to malaria control are needed for these areas. The encouraging results of a recent trial conducted in young children in Burkina Faso and Mali in which a combination of the RTS,S/AS01E malaria vaccine and seasonal malaria chemoprevention led to a substantial reduction in clinical cases of malaria, severe malaria, and malaria deaths compared with the administration of either intervention given alone suggests that there may be other epidemiological/clinical situations in which a combination of malaria vaccination and chemoprevention could be beneficial.

Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention

September 1, 2021 - 16:26 -- Open Access
Author(s): 
Chandramohan D, Zongo I, Greenwood B, et al.
Reference: 
N Engl J Med. 2021 Aug 25

Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions of Africa.

Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness

July 28, 2021 - 15:09 -- Open Access
Author(s): 
Koudraogo Bienvenue Yaméogo, Rakiswendé Serge Yerbanga, Jean Bosco Ouédraogo, et al.
Reference: 
Malaria Journal 2021 20:326, 27 July 2021

Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period. Whether the addition of azithromycin (AZ) to SMC could potentiate the benefit of the intervention was tested through a double-blind, randomized, placebo-controlled trial. The effect of SMC and the addition of AZ, on malaria transmission and on the life history traits of Anopheles gambiae mosquitoes have been investigated.

NOT Open Access | Prophylactic malaria chemoprevention reduces readmission and death rate in children previously admitted to hospital for treatment of severe anaemia

July 28, 2021 - 12:47 -- NOT Open Access
Author(s): 
Murphy S
Reference: 
Arch Dis Child Educ Pract Ed. 2021 Jul 21:edpract-2021-322075

No abstract available

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