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endothelial receptors

Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions

March 17, 2020 - 16:46 -- Open Access
Author(s): 
Lubiana P, Bouws P, Metwally NG, et al.
Reference: 
Sci Rep. 2020 Mar 11;10(1):4548

Characterizing the adhesive dynamics of Plasmodium falciparum infected erythrocytes (IEs) to different endothelial cell receptors (ECRs) in flow is a big challenge considering available methods. This study investigated the adhesive dynamics of IEs to five ECRs (CD36, ICAM-1, P-selectin, CD9, CSA) using simulations of in vivo-like flow and febrile conditions.

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