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Potential Emergence of Plasmodium Resistance to Artemisinin Induced by the Use of Artemisia annua for Malaria and COVID-19 Prevention in Sub-African Region

November 27, 2021 - 13:09 -- Open Access
Ataba E, Dorkenoo AM, Nguepou CT, Bakai T, Tchadjobo T, Kadzahlo KD, Yakpa K, Atcha-Oubou T
Acta Parasitol. 2021 Nov 19:1-6

Plasmodium resistance to antimalarial drugs is an obstacle to the elimination of malaria in endemic areas. This situation is particularly dramatic for Africa, which accounts for nearly 92% of malaria cases worldwide. Drug pressure has been identified as a key factor in the emergence of antimalarial drug resistance. Indeed, this pressure is favoured by several factors, including the use of counterfeit forms of antimalarials, inadequate prescription controls, poor adherence to treatment regimens, dosing errors, and the increasing use of other forms of unapproved antimalarials.

Pandemic-related delay of falciparum malaria diagnosis in a traveler leading to cerebral malaria

October 16, 2021 - 19:58 -- Open Access
Schubert L, Thurnher MM, Machold K, Tobudic S, Winkler S
J Travel Med. 2021 Oct 5:taab159

We report the case of a 29-year-old male in whom COVID-19 concerns led to a delayed diagnosis of falciparum malaria.

Relative Burdens of the COVID-19, Malaria, Tuberculosis, and HIV/AIDS Epidemics in Sub-Saharan Africa

October 16, 2021 - 12:16 -- Open Access
Bell D, Schultz Hansen K
Am J Trop Med Hyg. 2021 Oct 11:tpmd210899

COVID-19 has had considerable global impact; however, in sub-Saharan Africa, it is one of several infectious disease priorities. Prioritization is normally guided by disease burden, but the highly age-dependent nature of COVID-19 and that of other infectious diseases make comparisons challenging unless considered through metrics that incorporate life-years lost and time lived with adverse health.

Malaria and COVID-19 co-dynamics: A mathematical model and optimal control

October 11, 2021 - 19:39 -- Open Access
Tchoumi SY, Diagne ML, Rwezaura H, Tchuenche JM
Appl Math Model. 2021 Nov;99:294-327

Malaria, one of the longest-known vector-borne diseases, poses a major health problem in tropical and subtropical regions of the world. Its complexity is currently being exacerbated by the emerging COVID-19 pandemic and the threats of its second wave and looming third wave. We formulate and analyze a mathematical model incorporating some epidemiological features of the co-dynamics of both malaria and COVID-19. Sufficient conditions for the stability of the malaria only and COVID-19 only sub-models' equilibria are derived.

Insecticide-treated net distribution in Western Kenya: impacts related to COVID-19 and health worker strikes

August 18, 2021 - 17:14 -- Open Access
Suiyanka L, Alegana VA, Snow RW
Int Health. 2021 Aug 16:ihab051

We examined the impact of coronavirus disease (COVID) mitigation, supply and distribution interruptions on the delivery of long-lasting insecticide-treated nets (LLINs) in Western Kenya. The median monthly distribution of LLINs declined during COVID mitigation strategies (March-July 2020) and during the health worker strikes (December 2020-February 2021).

Public health-relevant consequences of the COVID-19 pandemic on malaria in sub-Saharan Africa: a scoping review

August 17, 2021 - 17:14 -- Open Access
Anna-Katharina Heuschen, Guangyu Lu, Oliver Razum, Alhassan Abdul-Mumin, Osman Sankoh, Lorenz von Seidlein, Umberto D’Alessandro and Olaf Müller
Malaria Journal 2021 20:339, 11 August 2021

The COVID-19 pandemic has resulted in unprecedented challenges to health systems worldwide, including the control of non-COVID-19 diseases. Malaria cases and deaths may increase due to the direct and indirect effects of the pandemic in malaria-endemic countries, particularly in sub-Saharan Africa (SSA). This scoping review aims to summarize information on public health-relevant effects of the COVID-19 pandemic on the malaria situation in SSA.

NOT Open Access | Novel malaria vaccines

August 10, 2021 - 18:19 -- NOT Open Access
Laurens MB
Hum Vaccin Immunother. 2021 Aug 4:1-4

Malaria vaccines hold significant promise for life-saving benefit, especially to children who bear the major burden of malaria mortality. The RTS,S/AS01 malaria vaccine provides moderate efficacy and is being tested in implementation studies. In parallel, multiple strategies are being advanced to test next-generation malaria vaccines, including novel approaches that build on principles learned from RTS,S development, vaccination with radiation-attenuated sporozoites, and development of monoclonal antibodies targeting immunogenic peptides.

Connected diagnostics to improve accurate diagnosis, treatment, and conditional payment of malaria services in Kenya

August 10, 2021 - 17:58 -- Open Access
van Duijn SMC, Siteyi AK, Rinke de Wit TF, et al.
BMC Med Inform Decis Mak. 2021 Aug 4;21(1):233

In sub-Saharan Africa, the material and human capacity to diagnose patients reporting with fever to healthcare providers is largely insufficient. Febrile patients are typically treated presumptively with antimalarials and/or antibiotics. Such over-prescription can lead to drug resistance and involves unnecessary costs to the health system. International funding for malaria is currently not sufficient to control malaria. Transition to domestic funding is challenged by UHC efforts and recent COVID-19 outbreak. Herewith we present a digital approach to improve efficiencies in diagnosis and treatment of malaria in endemic Kisumu, Kenya: Connected Diagnostics. The objective of this study is to evaluate the feasibility, user experience and clinical performance of this approach in Kisumu.

The key issues and development strategy of Chinese Classical Formulas pharmaceutical preparations

August 10, 2021 - 17:55 -- Open Access
Luo H, Chen H, Liu C, Zhang S, Vong CT, Tan D, Dai Y, Wang Y, Chen S
Chin Med. 2021 Aug 4;16(1):70

It is well-known that Prof. Tu Youyou won the Nobel Prize in Physiology or Medicine in 2015 due to the research on artemisinin treating malaria, and this can be regarded as the milestone of modernization of Traditional medicine. This first Nobel Prize in Traditional Chinese medicine (TCM) has aroused profound impetus in the investigation of TCM and attracted global attention to the ancient books of TCM.

Antimalarial drugs-are they beneficial in rheumatic and viral diseases?-considerations in COVID-19 pandemic

July 6, 2021 - 14:27 -- Open Access
Grygiel-Górniak B
Clin Rheumatol. 2021 Jul 3

The majority of the medical fraternity is continuously involved in finding new therapeutic schemes, including antimalarial medications (AMDs), which can be useful in combating the 2019-nCoV: coronavirus disease (COVID-19). For many decades, AMDs have been widely used in the treatment of malaria and various other anti-inflammatory diseases, particularly to treat autoimmune disorders of the connective tissue.


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