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in vivo challenge models

Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

March 23, 2020 - 11:30 -- Open Access
Rama Raghunandan, Bryan T. Mayer, Fidel Zavala, et al.
Malaria Journal 2020 19:113, 17 March 2020

New strategies are needed to reduce the incidence of malaria, and promising approaches include the development of vaccines and monoclonal antibodies (mAbs) that target the circumsporozoite protein (CSP). To select the best candidates and speed development, it is essential to standardize preclinical assays to measure the potency of such interventions in animal models.

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