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dihydroartemisinin/piperaquine

NOT Open Access | Efficacy of dihydroartemisinin/piperaquine in patients with non-complicated Plasmodium falciparum malaria in Yaounde, Cameroon

September 1, 2021 - 16:24 -- NOT Open Access
Author(s): 
Mairet-Khedim M, Nsango S, Berry A, et al.
Reference: 
J Antimicrob Chemother. 2021 Aug 28:dkab281

Dihydroartemisinin/piperaquine is increasingly used for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. The efficacy of this combination in Cameroon is poorly documented, while resistance to dihydroartemisinin/piperaquine readily spreads in Southeast Asia.

NOT Open Access | Efficacy of dihydroartemisinin/piperaquine and artesunate monotherapy for the treatment of uncomplicated Plasmodium falciparum malaria in Central Vietnam

August 3, 2020 - 16:24 -- NOT Open Access
Author(s): 
Rovira-Vallbona E, Van Hong N, Kattenberg JH, Huan RM, Hien NTT, Ngoc NTH, Guetens P, Hieu NL, Mai TT, Duong NTT, Duong TT, Phuc BQ, Xa NX, Erhart A, Rosanas-Urgell A
Reference: 
J Antimicrob Chemother. 2020 Aug 1; 75(8):2272-2281

Artemisinin-based combination therapies (ACTs) have significantly contributed to reduce Plasmodium falciparum malaria burden in Vietnam, but their efficacy is challenged by treatment failure of dihydroartemisinin/piperaquine ACT in Southern provinces.

NOT Open Access | Efficacy of dihydroartemisinin/piperaquine and artesunate monotherapy for the treatment of uncomplicated Plasmodium falciparum malaria in Central Vietnam

May 25, 2020 - 07:35 -- NOT Open Access
Author(s): 
Rovira-Vallbona E, Van Hong N, Rosanas-Urgell A, et al.
Reference: 
J Antimicrob Chemother. 2020 May 21:dkaa172

Artemisinin-based combination therapies (ACTs) have significantly contributed to reduce Plasmodium falciparum malaria burden in Vietnam, but their efficacy is challenged by treatment failure of dihydroartemisinin/piperaquine ACT in Southern provinces.

Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia

March 30, 2020 - 10:11 -- Open Access
Author(s): 
Roesch C, Mairet-Khedim M, Kim S, Lek D, Popovici J, Witkowski B
Reference: 
J Antimicrob Chemother. 2020 Mar 24. pii: dkaa092

Cambodia is the epicentre of the emergence of Plasmodium falciparum drug resistance. Much less is known regarding the drug susceptibility of the co-endemic Plasmodium vivax. Only in vitro drug assays can determine the parasite’s intrinsic susceptibility, but these are challenging to implement for P. vivax and rarely performed.

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