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piperonyl butoxide

A quasi-experimental study estimating the impact of long-lasting insecticidal nets with and without piperonyl butoxide on pregnancy outcomes

January 14, 2022 - 23:44 -- Open Access
Michelle E. Roh, Brenda Oundo, Grant Dorsey, Stephen Shiboski, Roly Gosling, M. Maria Glymour, Sarah G. Staedke, Adam Bennett, Hugh Sturrock and Arthur Mpimbaza
Malaria Journal 2022 21:5, 4 January 2022

Long-lasting insecticidal nets (LLINs) are the main vector control tool for pregnant women, but their efficacy may be compromised, in part, due to pyrethroid resistance. In 2017, the Ugandan Ministry of Health embedded a cluster randomized controlled trial into the national LLIN campaign, where a random subset of health subdistricts (HSDs) received LLINs treated with piperonyl butoxide (PBO), a chemical synergist known to partially restore pyrethroid sensitivity. Using data from a small, non-randomly selected subset of HSDs, this secondary analysis used quasi-experimental methods to quantify the overall impact of the LLIN campaign on pregnancy outcomes. In an exploratory analysis, differences between PBO and conventional (non-PBO) LLINs on pregnancy outcomes were assessed.

Bioefficacy and durability of Olyset® Plus, a permethrin and piperonyl butoxide-treated insecticidal net in a 3-year long trial in Kenya

December 27, 2021 - 10:44 -- Open Access
Gichuki PM, Kamau L, Njagi K, Karoki S, Muigai N, Matoke-Muhia D, Bayoh N, Mathenge E, Yadav RS
Infect Dis Poverty. 2021 Dec 20;10(1):135

Long-lasting insecticide nets (LLINs) are a core malaria intervention. LLINs should retain efficacy against mosquito vectors for a minimum of three years. Efficacy and durability of Olyset® Plus, a permethrin and piperonyl butoxide (PBO) treated LLIN, was evaluated versus permethrin treated Olyset® Net. In the absence of WHO guidelines of how to evaluate PBO nets, and considering the manufacturer’s product claim, Olyset® Plus was evaluated as a pyrethroid LLIN.

Evidence supporting deployment of next generation insecticide treated nets in Burkina Faso: bioassays with either chlorfenapyr or piperonyl butoxide increase mortality of pyrethroid-resistant Anopheles gambiae

October 29, 2021 - 14:17 -- Open Access
Aristide S. Hien, Dieudonné D. Soma, Roch K. Dabiré, et al.
Malaria Journal 2021 20:406, 18 October 2021

Pyrethroid resistance poses a major threat to the efficacy of insecticide-treated nets (ITNs) in Burkina Faso and throughout sub-Saharan Africa, particularly where resistance is present at high intensity. For such areas, there are alternative ITNs available, including the synergist piperonyl butoxide (PBO)-based ITNs and dual active ingredient ITNs such as Interceptor G2 (treated with chlorfenapyr and alpha-cypermethrin). Before deploying alternative ITNs on a large scale it is crucial to characterize the resistance profiles of primary malaria vector species for evidence-based decision making.

Susceptibility of Anopheles gambiae from Côte d’Ivoire to insecticides used on insecticide-treated nets: evaluating the additional entomological impact of piperonyl butoxide and chlorfenapyr

December 15, 2020 - 16:06 -- Open Access
Bernard L. Kouassi, Constant Edi, Emmanuel Tia, Lucien Y. Konan, Maurice A. Akré, Alphonsine A. Koffi, Allassane F. Ouattara, Antoine Mea Tanoh, Pascal Zinzindohoue, Blaise Kouadio, McKenzie Andre, Seth R. Irish, Jennifer Armistead, Dereje Dengela, Ndombour G. Cissé, Cecilia Flatley
Malaria Journal 2020 19:454, 9 December 2020

Pyrethroid-treated mosquito nets are currently the mainstay of vector control in Côte d’Ivoire. However, resistance to pyrethroids has been reported across the country, limiting options for insecticide resistance management due to the paucity of alternative insecticides. Two types of insecticide-treated nets (ITNs), ITNs with pyrethroids and the synergist piperonyl butoxide (PBO), and Interceptor®G2 nets, a net treated with a combination of chlorfenapyr and alpha-cypermethrin, are believed to help in the control of pyrethroid-resistant mosquitoes.

Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

April 20, 2020 - 09:38 -- Open Access
Staedke SG, Gonahasa S, Donnelly MJ, et al.
Lancet. 2020 Apr 18;395(10232):1292-1303

Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda’s national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors.

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