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synergism

'What I cannot create, I do not understand': functionally validated synergism of metabolic and target site insecticide resistance

May 27, 2020 - 10:39 -- Open Access
Author(s): 
Samantsidis GR, Panteleri R, Denecke S, Kounadi S, Christou I, Nauen R, Douris V, Vontas J
Reference: 
Proc Biol Sci. 2020 May 27;287(1927):20200838

The putative synergistic action of target-site mutations and enhanced detoxification in pyrethroid resistance in insects has been hypothesized as a major evolutionary mechanism responsible for dramatic consequences in malaria incidence and crop production. Combining genetic transformation and CRISPR/Cas9 genome modification, we generated transgenic Drosophila lines expressing pyrethroid metabolizing P450 enzymes in a genetic background along with engineered mutations in the voltage-gated sodium channel (para) known to confer target-site resistance.

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