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rapid diagnostic test

NOT Open Access | A deep learning approach to the screening of malaria infection: Automated and rapid cell counting, object detection and instance segmentation using Mask R-CNN

March 2, 2021 - 11:38 -- NOT Open Access
Loh R, Yong WX, Yapeter J, Subburaj K, Chandramohanadas R
Comput Med Imaging Graph. 2021 Mar;88:101845

Accurate and early diagnosis is critical to proper malaria treatment and hence death prevention. Several computer vision technologies have emerged in recent years as alternatives to traditional microscopy and rapid diagnostic tests. In this work, we used a deep learning model called Mask R-CNN that is trained on uninfected and Plasmodium falciparum-infected red blood cells.

The need for social group interventions to increase malaria rapid diagnostic test uptake in Nigeria

March 2, 2021 - 11:22 -- Open Access
Falade CO, Mokuolu OA
Lancet Glob Health. 2021 Mar;9(3):e231-e232

Correct diagnosis is key to appropriate treatment of any disease, whether infectious or otherwise, and is particularly pertinent for the diagnosis of malaria and, consequently, appropriate treatment.

NOT Open Access | Comparison of capillary versus venous blood for the diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests

January 31, 2021 - 15:45 -- NOT Open Access
Gorret AM, Muhindo R, Baguma E, Ntaro M, Mulogo EM, Deutsch-Feldman M, Juliano JJ, Nyehangane D, Boyce RM
J Infect Dis. 2021 Jan 27:jiab032

We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests when using capillary versus venous blood. Participants were tested with four different RDT types. PCR testing was performed as the reference standard. Sensitivity and specificity were broadly similar across RDT types and sampling method.

Predictors of malaria rapid diagnostic test positivity in a high burden area of Paletwa Township, Chin State in Western Myanmar

January 13, 2021 - 11:30 -- Open Access
Aung PL, Soe MT, Oo TL, Khin A, Thi A, Zhao Y, Cao Y, Cui L, Kyaw MP, Parker DM.
Infect Dis Poverty. 2021 Jan 11;10(1):6

Despite major reductions in malaria burden across Myanmar, clusters of the disease continue to persist in specific subregions. This study aimed to assess the predictors of test positivity among people living in Paletwa Township of Chin State, an area of persistently high malaria burden.

Trends of Malaria Morbidity and Mortality from 2010 to 2017 in Bale Zone, Ethiopia: Analysis of Surveillance Data

December 16, 2020 - 12:49 -- Open Access
Sani Kalil F, Hasen Bedaso M, Kabeta Wario S
Infect Drug Resist. 2020 Dec 8;13:4379-4387

Malaria is the major public health problem in sub-Saharan Africa, including Ethiopia. Ongoing malaria surveillance data analysis is useful for assessing incidences, trends over time, and evaluating the effectiveness of malaria prevention and control programs.

Impact of Plasmodium falciparum gene deletions on malaria rapid diagnostic test performance

November 4, 2020 - 15:15 -- Open Access
Michelle L. Gatton, Alisha Chaudhry, Jane Cunningham, et al.
Malaria Journal 2020 19:392, 4 November 2020

Malaria rapid diagnostic tests (RDTs) have greatly improved access to diagnosis in endemic countries. Most RDTs detect Plasmodium falciparum histidine-rich protein 2 (HRP2), but their sensitivity is seriously threatened by the emergence of pfhrp2-deleted parasites. RDTs detecting P. falciparum or pan-lactate dehydrogenase (Pf- or pan-LDH) provide alternatives. The objective of this study was to systematically assess the performance of malaria RDTs against well-characterized pfhrp2-deleted P. falciparum parasites.

Evaluation of the malaria reporting system supported by the District Health Information System 2 in Solomon Islands

October 20, 2020 - 16:26 -- Open Access
Kinley Wangdi, Haribondu Sarma, John Leaburi, Emma McBryde and Archie C. A. Clements
Malaria Journal 2020 19:372, 17 October 2020

District Health Information Systems 2 (DHIS2) is used for supporting health information management in 67 countries, including Solomon Islands. However, there have been few published evaluations of the performance of DHIS2-enhanced disease reporting systems, in particular for monitoring infectious diseases such as malaria. The aim of this study was to evaluate DHIS2 supported malaria reporting in Solomon Islands and to develop recommendations for improving the system.

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

October 13, 2020 - 12:43 -- Open Access
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich and Thierry Rolling
Malaria Journal 2020 19:366, 12 October 2020

Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present study aims to assess the prevalence of asymptomatic Plasmodium falciparum and non-falciparum infections in Ghanaian adults in the Ashanti region during the high transmission season.

Severe malaria in Cameroon: Pattern of disease in children at the Yaounde Gynaeco-Obstetric and Pediatric hospital

October 7, 2020 - 16:07 -- Open Access
Chiabi A, Djimafo ANM, Nguefack S, Mah E, Nguefack Dongmo F, Angwafo F 3rd
J Infect Public Health. 2020 Oct;13(10):1469-1472

Malaria is the most widely spread parasitic disease in the world, especially in the tropics affecting mostly children and pregnant women. In children, mostly under-fives carry the heaviest burden in terms of morbidity and mortality. The aim of this study was to determine the epidemiological and clinical aspects, and outcome of children 3 months to 15 years old with severe malaria at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH), a referral hospital in Yaounde, Cameroon.

NOT Open Access | Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion

October 7, 2020 - 14:48 -- NOT Open Access
Gibbons J, Qin J, Malla P, Wang Z, Brashear A, Wang C, Miao J, Adams JH, Kim K, Jiang R, Cui L
J Infect Dis. 2020 Oct 1;222(9):1561-1569

Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false-negative rapid diagnostic test (RDT) results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions.


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