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SDS-resistant oligomer

NOT Open Access | Molecular study of binding of Plasmodium ribosomal protein P2 to erythrocytes

July 28, 2020 - 14:09 -- NOT Open Access
Mishra P, Dmello C, Sengupta D, Chandrabhan Singh S, Kirkise N, Hosur RV, Sharma S
Biochimie. 2020 Jul 24:S0300-9084(20)30161-9

The ribosomal protein P2 of Plasmodium falciparum, (PfP2), performs certain unique extra-ribosomal functions. During the few hours of cell-division, PfP2 protein moves to the external surface of the infected erythrocytes (IE) as an SDS-resistant oligomer, and at that stage treatment with specific anti- PfP2 antibodies results in an arrest of the parasite cell-division.

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