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Antimalarial properties and molecular docking analysis of compounds from Dioscorea bulbifera L. as new antimalarial agent candidates

May 26, 2021 - 14:38 -- Open Access
Chaniad P, Mungthin M, Payaka A, Viriyavejakul P, Punsawad C
BMC Complement Med Ther. 2021 May 18;21(1):144

At present, the emergence and spread of antimalarial drug resistance has become a significant problem worldwide. There has been a challenge in searching for natural products for the development of novel antimalarial drugs. Therefore, this study aims to evaluate compounds from Dioscorea bulbifera responsible for antimalarial properties and investigate potential interactions of the compounds with Plasmodium falciparum lactate dehydrogenase (PfLDH), an essential glycolytic enzyme in the parasite’s life cycle.

Randomly positioned gold nanoparticles as fluorescence enhancers in apta-immunosensor for malaria test

February 25, 2021 - 10:24 -- Open Access
Minopoli A, Della Ventura B, Campanile R, Tanner JA, Offenhäusser A, Mayer D, Velotta R
Mikrochim Acta. 2021 Feb 16;188(3):88

A plasmon-enhanced fluorescence-based antibody-aptamer biosensor - consisting of gold nanoparticles randomly immobilized onto a glass substrate via electrostatic self-assembly - is described for specific detection of proteins in whole blood. Analyte recognition is realized through a sandwich scheme with a capture bioreceptor layer of antibodies - covalently immobilized onto the gold nanoparticle surface in upright orientation and close-packed configuration by photochemical immobilization technique (PIT) - and a top bioreceptor layer of fluorescently labelled aptamers.

NOT Open Access | Evaluation of PfHRP2 and PfLDH Malaria Rapid Diagnostic Test Performance in Assosa Zone, Ethiopia

August 26, 2020 - 15:32 -- NOT Open Access
Alemayehu GS, Lopez K, Dieng CC, Lo E, Janies D, Golassa L
Am J Trop Med Hyg. 2020 Aug 24

In malaria-endemic countries, rapid diagnostic tests (RDTs) targeting Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and lactate dehydrogenase (PfLDH) have been widely used. However, little is known regarding the diagnostic performances of these RDTs in the Assosa zone of northwest Ethiopia. The objective of this study was to determine the diagnostic performances of PfHRP2 and PfLDH RDTs using microscopy and quantitative PCR (qPCR) as a reference test.

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