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human blood

NOT Open Access | Determination of antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography: a review

October 12, 2021 - 10:53 -- NOT Open Access
Penna EA, de Souza JCQ, de Oliveira MAL, Chellini PR
Anal Methods. 2021 Oct 6

Malaria is a life-threatening disease being treated by oral medication. This is the best treatment to reduce morbidity and mortality, prevent disease progression to the most severe form, lower the transmission of the disease and hinder the appearance of strains resistant to antimalarials.

NOT Open Access | Mutagenesis of the orco odorant receptor co-receptor impairs olfactory function in the malaria vector Anopheles coluzzii

December 3, 2020 - 12:19 -- NOT Open Access
Sun H, Liu F, Ye Z, Baker A, Zwiebel LJ
Insect Biochem Mol Biol. 2020 Dec;127:103497

Mosquitoes rely heavily on their olfactory systems for host seeking, selection of oviposition sites, and avoiding predators and other environmental dangers. Of these behaviors, the preferential selection of a human blood-meal host drives the vectorial capacity of anthropophilic female Anopheles coluzzii mosquitoes. Olfactory receptor neurons (ORNs) are dispersed across several appendages on the head and express an obligate odorant receptor co-receptor (Orco) coupled with a "tuning" odorant receptor (OR) to form heteromeric, odor-gated ion channels in the membrane of these neurons.

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